A5100756444- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Nitric Oxide and Endothelin Effects
- Cardiovascular Function and Risk Factors
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Adipose Tissue and Metabolism
- Pain Mechanisms and Treatments
- MicroRNA in disease regulation
- Cardiac Fibrosis and Remodeling
- Heme Oxygenase-1 and Carbon Monoxide
- Intensive Care Unit Cognitive Disorders
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Eicosanoids and Hypertension Pharmacology
- Autophagy in Disease and Therapy
- COVID-19 Clinical Research Studies
- Caveolin-1 and cellular processes
- Organ Transplantation Techniques and Outcomes
- COVID-19 and healthcare impacts
- Metabolism, Diabetes, and Cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac electrophysiology and arrhythmias
University of Hong Kong
2016-2025
Zhengzhou Central Hospital
2025
Guangdong Medical College
2014-2024
Affiliated Hospital of Guangdong Medical College Hospital
2014-2024
City University of Hong Kong
2024
First Affiliated Hospital of Jinan University
2024
Chinese University of Hong Kong
2014-2023
Macau University of Science and Technology
2023
Zhanjiang Experimental Station
2021-2022
Second Affiliated Hospital of Zhengzhou University
2020-2021
The outbreak of 2019 novel coronavirus disease (COVID-19) in Wuhan, China, has spread rapidly worldwide. In the early stage, we encountered a small but meaningful number patients who were unintentionally scheduled for elective surgeries during incubation period COVID-19. We intended to describe their clinical characteristics and outcomes.We retrospectively analyzed data 34 underwent COVID-19 at Renmin Hospital, Zhongnan Tongji Hospital Central from January 1 February 5, 2020.Of operative...
Abstract Propofol infusion syndrome (PRIS) is an uncommon life-threatening complication observed most often in patients receiving high-dose propofol. High-dose propofol treatment with a prolonged duration can damage the immune system. However, associated molecular mechanisms remain unclear. An increasing number of clinical and experimental observations have demonstrated that tissue-resident macrophages play critical role regulation during anaesthesia procedural sedation. Since inflammatory...
Cardiac dysfunction resulting from sepsis may cause significant morbidity and mortality, ferroptosis plays a role in this pathology. Dexmedetomidine (Dex), α2‑adrenergic receptor (α2‑AR) agonist exerts cardioprotective effects against septic heart dysfunction, but the exact mechanism is unknown. In present study, was induced by cecal ligation puncture (CLP) male C57BL/6 mice. Dex yohimbine hydrochloride (YOH), an α2‑AR inhibitor, were administered before inducing CLP. Then, 24 h after CLP,...
Genome-wide association studies (GWASs), now as a routine approach to study single-nucleotide polymorphism (SNP)-trait association, have uncovered over ten thousand significant trait/disease associated SNPs (TASs). Here, we updated GWASdb (GWASdb v2, http://jjwanglab.org/gwasdb) which provides comprehensive data curation and knowledge integration for GWAS TASs. These updates include: (i) Up August 2015, collected 2479 unique publications from PubMed other resources; (ii) We further curated...
Abstract Cytoprotective gene heme oxygenase 1 (HO-1) could be induced by nuclear factor E2-related 2 (Nrf2) translocation. The purpose of this study was to determine the role Brahma-related (Brg1), a catalytic subunit SWI2/SNF2-like chromatin remodeling complexes, in Nrf2/HO-1 pathway activation during hepatic ischemia–reperfusion (HIR). Our results showed that Brg1 inhibited early HIR while overexpression reduced oxidative injury CMV-Brg1 mice subjected HIR. Moreover, promoter-driven...
Interpreting the genetic variants located in regulatory regions, such as enhancers and promoters, is an indispensable step to understand molecular mechanism of complex traits. Recent studies show that detected by genome-wide association study (GWAS) are significantly enriched regions. Therefore, detecting, annotating prioritizing affecting gene regulation critical our understanding genotype–phenotype relationships. Here, we developed a web server GWAS3D systematically analyze could affect...
Allopurinol (ALP) attenuates oxidative stress and diabetic cardiomyopathy (DCM), but the mechanism is unclear. Activation of nuclear factor erythroid 2-related 2 (Nrf2) following disassociation with its repressor Keap1 under can maintain inner redox homeostasis attenuate DCM concomitant attenuation autophagy. We postulated that ALP treatment may activate Nrf2 to mitigate autophagy over-activation consequently DCM. Streptozotocin-induced type 1 rats were untreated or treated (100 mg/kg/d) for...
Protein kinase C (PKC)β2 is preferably overexpressed in the diabetic myocardium, which induces cardiomyocyte hypertrophy and contributes to cardiomyopathy, but underlying mechanisms are incompletely understood. Caveolae critical signal transduction of PKC isoforms cardiomyocytes. Caveolin (Cav)-3, cardiomyocyte-specific caveolar structural protein isoform, decreased heart. The current study determined whether PKCβ2 activation affects caveolae Cav-3 expression. Immunoprecipitation...
Abstract Cardiovascular diseases such as myocardial ischaemia have a high fatality rate in patients with diabetes. This study was designed to expose the crosstalk between oxidative stress and AMPK, vital molecule that controls biological energy metabolism, reperfusion injury (I/RI) diabetic rats. Diabetes stimulated rats using streptozotocin injection. Rats were separated on random into control, control + I/R, Diabetes, I/R N‐acetylcysteine Vas2870 groups. Myocardial infarct size determined,...
Chemokine axis chemokine C-X-C motif ligand 12/C-X-C receptor type 4 (CXCL12/CXCR4) is an emerging pain modulator, but mechanisms for its involvement in neuropathic remain unclear. Here, we aimed to study whether CXCL12/CXCR4 modulated the development of via glial mechanisms. In this study, two mouse models pain, namely partial sciatic nerve ligation (pSNL) model and chronic post-ischemia (CPIP) model, were used.In dorsal horn L3-L5 segment spinal cord, CXCL12 CXCR4 expressed both astrocyte...
Abstract The hearts of subjects with diabetes are vulnerable to ischemia–reperfusion injury (IRI). In contrast, experimentally rodent have been shown be more resistant IRI at the very early stages induction than heart non-diabetic control mice, and mechanism is largely unclear. Ferroptosis has recently play an important role in myocardial including that diabetes, while specific mechanisms still Non-diabetic (NC) streptozotocin-induced diabetic (DM) mice were treated antioxidant...
Studies in streptozotocin (STZ)-induced diabetic rats have demonstrated cardiovascular abnormalities such as depressed mean arterial blood pressure (MABP) and heart rate (HR), endothelial dysfunction, attenuated pressor responses to vasoactive agents. We investigated whether these are due diabetes-associated activation of inducible nitric oxide synthase (iNOS). In addition, the effect duration diabetes on was also evaluated. Diabetes induced by administration 60 mg/kg STZ via tail vein. One,...
We investigated if increasing propofol's dosage to augment its antioxidant capacity during cardiopulmonary bypass (CPB) could confer cardiac protection. Fifty-four coronary artery graft surgery patients were randomly assigned small-dose propofol (Group P; n = 18), large-dose HiP; or isoflurane Group I; 18). After the induction, anesthesia was maintained with an inspired concentration of 1%-3.5% I) a continuous infusion 60 microg x kg(-1) min(-1) P) throughout surgery. In HiP, this dose...
Signal transducer and activator of transcription 3 (STAT3) activation is key for ischemic postconditioning (IPo) to attenuate myocardial ischemia-reperfusion injury (MIRI), but IPo loses cardioprotection in diabetes which cardiac STAT3 impaired adiponectin (APN) reduced. We found that increased postischemic cardiomyocyte-derived APN, activated mitochondrial (mitoSTAT3), improved function, attenuated MIRI wild-type not APN knockout (Adipo−/−) mice subjected 30 min coronary occlusion, followed...
Either isoflurane preconditioning or high-dose propofol treatment has been shown to attenuate myocardial IRI (ischaemia/reperfusion injury) in patients undergoing CABG (coronary artery bypass graft) surgery. It is unknown whether and may synergistically injury patients. The present study investigated the efficacy of IsoPC (isoflurane preconditioning), (postconditioning) their synergy attenuating postischaemic surgery using CPB (cardiopulmonary bypass). Patients (n = 120) selected for were...
Sepsis leads to severe acute lung injury/acute respiratory distress syndrome (ALI/ARDS) that is associated with enhanced endoplasmic reticulum (ER) stress. Heme oxygenase-1 (HO-1), an ER-anchored protein, exerts antioxidant and protective functions under ALI. However, the role of HO-1 activation in development stress during sepsis remains unknown.Cecal ligation puncture (CLP) model was created induce septic Lung tissue ER measured 18 hours after CLP. The effects on ALI were investigated vivo...