A5065596712- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Pulmonary Hypertension Research and Treatments
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Cardiovascular and Diving-Related Complications
- Cardiovascular Issues in Pregnancy
- Hormonal Regulation and Hypertension
- HIV/AIDS Research and Interventions
- Lung Cancer Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- RNA modifications and cancer
- Chronic Lymphocytic Leukemia Research
- Mechanical Circulatory Support Devices
- Heart Failure Treatment and Management
- Neurological disorders and treatments
- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Pericarditis and Cardiac Tamponade
- Adrenal and Paraganglionic Tumors
- Inflammasome and immune disorders
Peking University First Hospital
2014-2024
Peking University
2014-2024
Lanzhou Jiaotong University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
China Medical University
2015-2023
Tianjin Chest Hospital
2023
Nankai University
2023
Chengdu University of Traditional Chinese Medicine
2023
First Hospital of China Medical University
2015-2023
University of South China
2022
Abstract Propofol infusion syndrome (PRIS) is an uncommon life-threatening complication observed most often in patients receiving high-dose propofol. High-dose propofol treatment with a prolonged duration can damage the immune system. However, associated molecular mechanisms remain unclear. An increasing number of clinical and experimental observations have demonstrated that tissue-resident macrophages play critical role regulation during anaesthesia procedural sedation. Since inflammatory...
Continuous and reliable monitoring of blood pressure cardiac function is great importance for diagnosing preventing cardiovascular diseases. However, existing approaches are bulky costly, limiting their wide applications early diagnosis. Here, we developed an intelligent system based on a conformal flexible strain sensor array deep learning neural networks. The has variety advantages, including high sensitivity, linearity, fast response recovery, isotropy. Experiments simulation...
This study aimed to assess the clinical characteristics and long-term survival outcome in patients with Takayasu's arteritis-associated pulmonary hypertension (TA-PH).We conducted a nationally representative cohort of TA-PH using data from National Rare Diseases Registry System China. Patients artery involvement who fulfilled diagnostic criteria arteritis were included. The primary was time diagnosis occurrence all-cause death. Between January 2007 2019, total 140 included, mean age 41.4...
Background: Cardiac amyloidosis (CA) is one of the causes heart failure with preserved ejection fraction. magnetic resonance (CMR) late gadolinium enhancement (LGE) and extracellular volume (ECV) fractions a preferred method to identify CA. However, requirement contrast limits its use in renal deficiency patients. Myocardial strain promising without contrast. We sought assess early diagnostic prognostic value strain. Methods: This retrospective study enrolled 31 patients systemic (SA) Peking...
Using delayed-rectifier potassium channels as examples, we have designed two specific blockers by generating antipeptide antibodies to epitopes in the external vestibules of channel proteins, Kv1.2 and Kv3.1. These reduced whole-cell or Kv3.1 currents transfected cells effect was blocked corresponding peptide antigen, but not control peptides. A antibody had little on blocker limited other related currents. Furthermore, blocking inhibited dendrotoxin binding proteins cells. Moreover, using...
Interarm systolic blood pressure difference ( IASBPD ) can predict cardiovascular disease. To investigate the relationship between and disease risk factors, a total of 1426 individuals were studied. Blood was assessed simultaneously expressed as absolute value (|R−L|). Cardiovascular factors compared high group ≥10 mm Hg) normal <10 Hg). An increased prevalence hypertension, body mass index , diastolic observed in P <.05), associated with enhanced mean values intima–media thickness...
Abstract Background This study aimed to quantitatively evaluate the left ventricular global and regional myocardial work of patients in Fabry disease (FD) by echocardiographic pressure–strain loop (PSL) analysis. Results The included 48 with FD healthy controls matched for age sex. According presence/absence hypertrophy (LVH), were divided into an LVH + group LVH– group. Left blood pressure was estimated noninvasively according valvular events systolic brachial artery. parameters acquired...
Diabetic nephropathy is a major complication of diabetes mellitus and related to dysfunction renal cells. Hederagenin triterpenoid saponin from some Chinese herbs with anti-inflammatory anti-diabetic activities. However, its role in diabetic progression still obscure. This study aimed explore the effects hederagenin on cell vitro. Human mesangial cells (HRMCs) human proximal tubular epithelial (HRPTEpiCs) were cultured under high glucose (HG) conditions mimic nephropathy-like injury. Cell...
Abstract Background The left atrium (LA) is closely related to ventricular diastolic function. Two-dimensional speckle tracking strain and rate (SR) imaging has been applied in the study of LA We intended explore relationship between global deformation parameters plasma NTproBNP levels asymptomatic community residents with normal ejection fraction volume. Methods A cross-sectional sample Beijing underwent comprehensive Doppler echocardiography medical record review 2009. Global longitudinal...
Abstract Background The evidence that dynamic variables predict fluid responsiveness in young children is limited by conflicting research results. Methods Sixty patients, 1–3 years of age, undergoing major neurosurgery, received 10 mL/kg Ringer's solution over min after anesthesia induction. Respiratory variation aortic blood flow peak velocity (∆Vpeak), plethysmographic variability index (PVI), FloTrac/Vigileo‐derived stroke volume (SVV), arterial elastance (Ea dyn ), and pulse pressure...
Abstract We aimed to investigate the association of brachial–ankle pulse wave velocity (baPWV) with carotid plaque presence and number in a Chinese hypertensive population. A total 13,554 subjects from China Stroke Primary Prevention Trial (CSPPT) were recruited. Arterial stiffness evaluated by baPWV B-mode ultrasonography, respectively. Multivariate logistic regression analysis was used determine correlation presence. Multinomial number. Further interactions between examined using subgroup...
Abstract This meta‐analysis evaluated the potential association of a simultaneously measured inter‐arm systolic blood pressure difference (IASBPD) and all‐cause mortality cardiovascular mortality. The Medline, Cochrane Library, Embase, PubMed databases were searched through to April 14, 2023 for relevant literature. outcomes associations IASBPD with Finally, 10 cohort studies that included 15 320 individuals included. An ≥15 mm Hg was associated increased (pooled hazard ratio [HR] 1.28, 95%...
Minipolymyoclonus has been described in both anterior horn cell disorders and central nervous system degenerative conditions. While its etiology remains unclear speculative, a generator previously proposed. We describe case of bulbospinal muscular atrophy (Kennedy's disease), where minipolymyoclonus-like movements corresponded to fasciculations neurophysiological studies. Our novel finding suggests that the etiologies minipolymyoclonus peripheral are distinct, despite outward clinical...