A5035533945- Anesthesia and Sedative Agents
- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Tryptophan and brain disorders
- Immune Response and Inflammation
- Mitochondrial Function and Pathology
- Airway Management and Intubation Techniques
- Anesthesia and Neurotoxicity Research
- Neonatal Respiratory Health Research
- Sepsis Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Parathyroid Disorders and Treatments
- Alzheimer's disease research and treatments
- Sirtuins and Resveratrol in Medicine
- Pituitary Gland Disorders and Treatments
- Ferroptosis and cancer prognosis
- Ion Transport and Channel Regulation
- Nerve injury and regeneration
- Ultrasound in Clinical Applications
- Drug-Induced Hepatotoxicity and Protection
Southern University of Science and Technology
2021-2024
Jinan University
2017-2024
ShenZhen People’s Hospital
2015-2023
Shenzhen Blood Center
2021
Huazhong University of Science and Technology
2013
Abstract Propofol infusion syndrome (PRIS) is an uncommon life-threatening complication observed most often in patients receiving high-dose propofol. High-dose propofol treatment with a prolonged duration can damage the immune system. However, associated molecular mechanisms remain unclear. An increasing number of clinical and experimental observations have demonstrated that tissue-resident macrophages play critical role regulation during anaesthesia procedural sedation. Since inflammatory...
A wide spectrum of changes occurs in the brain with age, from molecular to morphological aspects, and inflammation accompanied by mitochondria dysfunction is one significant factors associated age. Adiponectin (APN), an essential adipokine glucose lipid metabolism, involved aging; however, its role aging has not been adequately explored. Here, we aimed explore relationship between APN deficiency using multiple biochemical pharmacological methods probe humans, KO mice, primary microglia, BV2...
Background: Alzheimer's disease (AD) is the most common form of dementia worldwide. Previous studies have reported that sevoflurane, a frequently used anesthetic, can induce cognitive impairment in preclinical and clinical settings. However, mechanism underlying development this neurotoxicity currently unclear. Methods: Seven-month-old APP/PS1 mice were placed an anesthesia induction box containing 3% sevoflurane 100% O2 for 6 h, while BV2 cells cultured with 4% h. Pyroptosis tau protein...
The deleterious effects of aging on the brain remain to be fully elucidated. In present study, proteomic changes young (4-month) and aged (16-month) B6129SF2/J male mouse hippocampus cerebral cortex were investigated by using nano liquid chromatography tandem mass spectrometry (NanoLC-ESI-MS/MS) combined with tag (TMT) labeling technology. Compared animals, 390 hippocampal proteins (121 increased 269 decreased) 258 cortical (149 109 changed significantly in mouse. Bioinformatic analysis...
Abstract Dexmedetomidine (Dex), a highly selective α 2 -adrenergic receptor (α AR) agonist, has an anti-inflammatory property and can alleviate pulmonary edema in lipopolysaccharide (LPS)-induced acute lung injury (ALI), but the mechanism is still unclear. In this study, we attempted to investigate effect of Dex on alveolar epithelial sodium channel (ENaC) modulation fluid clearance (AFC) underlying mechanism. Lipopolysaccharide (LPS) was used induce (ALI) rats cell A549 cells. vivo,...
The aim of the present study was to investigate effects 3-methyladenine (3-MA) and dexmedetomidine (DEX) pretreatment on lipopolysaccharide (LPS)-induced acute lung injury (ALI) potential mechanism underlying effects. LPS instilled into trachea BALB/c mice induce ALI model. Solutions 3-MA or DEX were intravenously injected 1 h later establish groups. On days 1, 3 5 after injections, arterial blood gas analysis conducted, wet-dry weight ratio (W/D) determined. In addition, albumin, cytokine...
Malic acid, in the form of its anion malate, is a key intermediate major biochemical energy-producing cycle known as citric acid or Krebs cycle. In this study, authors investigated protective effect novel crystalloid solution Ringer’s malate following fluid resuscitation hemorrhagic shock using rat model. Under general anesthesia, Sprague-Dawley male rats were subjected to 60 min (40 mmHg for min) followed by resuscitation. Groups follows: (1) sham shock, (2) normal saline, (3) lactate, and...
The ideal depth of general anesthesia should achieve the required levels hypnosis, analgesia, and muscle relaxation while minimizing physiologic responses to awareness. choice anesthetic strategy in patients with coronary heart disease (CHD) undergoing major noncardiac surgery is becoming an increasingly important issue as population ages. This because associated a risk perioperative cardiac complications death, this much higher people CHD.
Abstract Background Trimetazidine (TMZ) pretreatment protects cardiomyocytes during cardiac surgery. TMZ may protect elderly patients with ischaemic heart disease (IHD) undergoing non-cardiac Methods This was a randomized, double-blind, placebo-controlled trial (registration #ChiCTR1900025018) of IHD scheduled to undergo surgery at Shenzhen People’s Hospital (Shenzhen, Guangdong Province, China) between June 2014 and September 2015, randomized 60 mg or placebo 12 h before The primary...
The aim of the present study was to investigate effects target-controlled infusion (TCI) propofol and remifentanil combined with dexmedetomidine on functional endoscopic sinus surgery (FESS) bleeding surgical field. 62 patients scheduled undergo FESS were randomly divided into experimental group (intravenous 0.5 µg kg-1 h-1 after bolus within 15 min until end surgery) or control saline administration at same dose). All underwent endotracheal intubation under general anesthesia TCI for...
Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative disorders among elderly. However, there no reliable drug for treatment AD, which largely due to unknown mechanisms and lack credible targets. Some studies demonstrated hat brain-derived neurotrophic factor/tropomyosin receptor kinase B (BDNF/TrkB) signaling pathway may be a potential therapeutic target AD. As widely studied neurotrophin in brain, BDNF has high affinity TrkB plays an important role regulation neuronal...
Abstract There has been interest in the use of nonintubated techniques for video-assisted thoracoscopic surgery (VATS) both awake and sedated patients. The authors’ centre developed a technique with spontaneous ventilation patient under general anaesthesia using phrenic nerve block. This treatment was compared case-matched control group. authors believe that this is beneficial optimizing patients undergoing VATS. were randomly allocated (1:1) to block (PNB) group Both groups received...
BACKGROUND Volatile anesthesia possesses cardioprotective properties, and it is widely used in patients undergoing coronary artery bypass surgery, but no randomized controlled trials (RCTs) are available on the use of sevoflurane-remifentanil versus propofol-remifentanil for with disease (CAD) during noncardiac surgery. This study was designed to compare 2 different types general CAD surgery at a single center. MATERIAL AND METHODS Patients were enrolled an RCT conducted between March 2016...
Manganese (Mn) is required for normal brain development and function. Excess Mn may trigger a parkinsonian movement disorder but the underlying mechanisms are incompletely understood. We explored changes in proteomic profile behavior of adult Sprague Dawley (SD) rats systemically treated with or without 1.0 mg/mL MnCl2 3 months. treatment significantly increased concentration protein-bound external globus pallidus (GP), as demonstrated by inductively coupled plasma mass spectrometry....
Objective To investigate the effects of different doses dexmedetomidine combined with propofol and remifentanil target controlled infusion (TCI) on postanesthesia recovery patients in functional endoscopic sinus surgery. Methods Eighty ASA Ⅰ or Ⅱ grade patients, scheduled for surgery, were divided into control group (20 cases) (60 according to random digits table method. The given loading dose 0.6 µg/kg, then maintenance doses: 0.3 µg/(kg·h) D1 group, D2 0.9 D3 group. TCI during...