A5081547005- Cell death mechanisms and regulation
- interferon and immune responses
- Immune Response and Inflammation
- Immune cells in cancer
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Analysis
- Monoclonal and Polyclonal Antibodies Research
- Ferroptosis and cancer prognosis
- RNA regulation and disease
- Genetic factors in colorectal cancer
- Pharmacy and Medical Practices
- Hedgehog Signaling Pathway Studies
- S100 Proteins and Annexins
- Pancreatitis Pathology and Treatment
- Blockchain Technology Applications and Security
- Bone health and osteoporosis research
- Pediatric health and respiratory diseases
- Cellular transport and secretion
- Cancer Risks and Factors
- Calcium signaling and nucleotide metabolism
- Advanced biosensing and bioanalysis techniques
Xiamen University
2009-2025
Sun Yat-sen University
2025
Third Affiliated Hospital of Sun Yat-sen University
2025
Fujian Medical University
2013-2024
University of Cologne
2014-2024
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2016-2024
Albert Einstein College of Medicine
2012-2021
Jinan University
2012-2021
Southern University of Science and Technology
2021
Fujian Provincial Hospital
2018-2020
Necrosis can be induced by stimulating death receptors with tumor necrosis factor (TNF) or other agonists; however, the underlying mechanism differentiating from apoptosis is largely unknown. We identified protein kinase receptor-interacting 3 (RIP3) as a molecular switch between TNF-induced and in NIH 3T3 cells found that RIP3 was required for cells. did not affect RIP1-mediated but enhancement of caspase inhibitor zVAD. By activating key enzymes metabolic pathways, regulates reactive...
The programmed death-1 (PD-1) costimulatory receptor inhibits T and B cell responses plays a crucial role in peripheral tolerance. PD-1 has recently been shown to inhibit during chronic viral infections such as HIV. In this study, we examined the of infection with Mycobacterium tuberculosis , common co-infection PD-1–deficient mice showed dramatically reduced survival compared wild-type mice. lungs −/− uncontrolled bacterial proliferation focal necrotic areas predominantly neutrophilic...
Necrotic death of macrophages has long been known to be present in atherosclerotic lesions but not studied. We examined the role receptor interacting protein (RIP) 3, a mediator necrotic cell death, atherosclerosis and found that RIP3(-/-);Ldlr(-/-) mice were no different from RIP3(+/+);Ldlr(-/-) early had significant reduction advanced lesions. Similar results observed Apoe(-/-) background mice. Bone marrow transplantation revealed loss RIP3 expression bone-marrow-derived cells is...
RIPK1 is a multi-functional kinase that regulates cell death and inflammation has been implicated in the pathogenesis of inflammatory diseases. acts kinase-dependent kinase-independent manner to promote or suppress apoptosis necroptosis, but underlying mechanisms remain poorly understood. Here, we show mutation (R588E) disrupting domain (DD) caused perinatal lethality induced by ZBP1-mediated necroptosis. Additionally, these mice developed postnatal pathology, which was mediated...
B7x (B7-H4 or B7S1) is the seventh member of B7 family, and its in vivo function remains largely unknown. Despite new genetic data linking gene with autoimmune diseases, how exactly it contributes to peripheral tolerance autoimmunity unclear. In this study, we showed that protein was not detected on APCs T cells both human mice, which unique family. Because expressed some such as pancreatic β cells, used a CD8 cell-mediated diabetes model (AI4αβ) recognize an endogenous self-Ag, found mice...
Background Increasing evidence is showing that necroptosis has unique clinical significance in the occurrence and development of multiple diseases. Here, we systematically evaluate role clear cell renal carcinoma (ccRCC) analyze its regulatory patterns. Methods First, evaluated expression enrichment necroptotic factors ccRCC using gene set analysis (GSEA) survival profile from The Cancer Genome Atlas (TCGA) to demonstrate overall mutation pathway genes. Then, used unsupervised clustering...
Background Epidemiologic data linking metabolic markers-such as insulin, insulin-like growth factors (IGFs)-and adipose tissue-derived with cancer are inconsistent. Between-study differences in blood collection protocols, particular participant’s fasting status, may influence measurements. Methods We investigated the impact of status and sample processing time on components insulin/IGF axis adipokines a controlled feeding study 45 healthy postmenopausal-women aged 50–75 years. Fasting...
The coronavirus disease 2019 (COVID-19) pandemic, which caused by severe acute respiratory syndrome 2 (SARS-CoV-2), lead to a crisis with devastating disasters global public economy and health. Several studies suggest that the SARS-CoV-2 nucleocapsid protein (N protein) is one of uppermost structural constituents relatively conserved could become specific diagnostic marker. In this study, eight single domain antibodies recognized N specifically were named pN01–pN08 screened using human phage...
As an outstanding representative of traditional Chinese medicine(TCM) prescriptions accumulated from famous TCM doctors' clinical experiences in past dynasties, classical excellent (cTCMeP) are the most valuable part system. To support research and development cTCMeP, a series regulations measures were issued to encourage its simplified registration. There is still long-way go because many key problems puzzles about technology, registration administration cTCMeP R&D process not resolved....
To identify the independent factors of unplanned interruption during continuous renal replacement therapy (CRRT) and construct a risk prediction model, to verify clinical application effectiveness model.