A5102863131- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Organ Transplantation Techniques and Outcomes
- Enhanced Recovery After Surgery
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Liver Disease and Transplantation
- Electroconvulsive Therapy Studies
- Nausea and vomiting management
- Hemodynamic Monitoring and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Connexins and lens biology
- Transplantation: Methods and Outcomes
- Treatment of Major Depression
- Cancer, Stress, Anesthesia, and Immune Response
- Obstructive Sleep Apnea Research
- Metabolomics and Mass Spectrometry Studies
- Kidney Stones and Urolithiasis Treatments
- Takotsubo Cardiomyopathy and Associated Phenomena
- Acute Kidney Injury Research
- Liver Disease Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Cardiac Ischemia and Reperfusion
Third Affiliated Hospital of Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Guangdong Medical College
2019
National Natural Science Foundation of China
2016
Abstract Cytoprotective gene heme oxygenase 1 (HO-1) could be induced by nuclear factor E2-related 2 (Nrf2) translocation. The purpose of this study was to determine the role Brahma-related (Brg1), a catalytic subunit SWI2/SNF2-like chromatin remodeling complexes, in Nrf2/HO-1 pathway activation during hepatic ischemia–reperfusion (HIR). Our results showed that Brg1 inhibited early HIR while overexpression reduced oxidative injury CMV-Brg1 mice subjected HIR. Moreover, promoter-driven...
Background Postoperative sepsis is one of the main causes mortality after liver transplantation (LT). Our study aimed to develop and validate a predictive model for postoperative within 7 d in LT recipients using machine learning (ML) technology.Methods Data 786 patients received from January 2015 2020 was retrospectively extracted big data platform Third Affiliated Hospital Sun Yat-sen University. Seven ML models were developed predict sepsis. The area under receiver-operating curve (AUC),...
Early prediction of acute kidney injury (AKI) after liver transplantation (LT) facilitates timely recognition and intervention. We aimed to build a risk predictor post-LT AKI via supervised machine learning visualize the mechanism driving within assist clinical decision-making.Data 894 cases that underwent from January 2015 September 2019 were collected, covering demographics, donor characteristics, etiology, peri-operative laboratory results, co-morbidities medications. The primary outcome...
Approximately 42% of patients with sepsis undergo acute kidney injury (AKI), which evidently influences patient survival. However, effective therapy strategies are lacking, thus, the present study investigated protective effects dexmedetomidine (DEX), a highly selective α-2 adrenoceptor agonist, in rat models. Rat models were generated through lipopolysaccharide injection (LPS; 5 mg/kg) tail vein. Rats pretreated DEX (10 µg/kg) 10 min before LPS to observe its effects. Of note, unique...
Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) signaling plays a dominant role in the pathogenesis of liver ischemia-reperfusion (IR) injury. Dexmedetomidine (Dex) protects against IR injury via α₂-adrenoceptor activation, but contribution TLR4 remains unknown. The authors aimed to examine whether pretreatment with Dex produces hepatic protection and investigate influence on TLR4/NF-κB signaling. was given intraperitoneal injection 30 min prior orthotopic autologous...
Ischemia-reperfusion (I/R)-induced acute kidney injury (AKI) not only prolongs the length of hospital stay, but also seriously affects patient's survival rate. Although our previous investigation has verified that reactive oxygen species (ROS) transferred through gap junction composed connexin32 (Cx32) contributed to AKI, its underlying mechanisms were fully understood and viable preventive or therapeutic regimens still lacking. Among various involved in organs I/R-induced injuries,...
Abstract Background Pneumonia is the most frequently encountered postoperative pulmonary complications (PPC) after orthotopic liver transplantation (OLT), which cause high morbidity and mortality rates. We aimed to develop a model predict pneumonia in OLT patients using machine learning (ML) methods. Methods Data of 786 adult underwent at Third Affiliated Hospital Sun Yat-sen University from January 2015 September 2019 was retrospectively extracted electronic medical records randomly...
Sepsis is a severe complication that results in increased morbidity and mortality after intestinal obstruction surgery. This study examined the role of preoperative systemic immune inflammation index (SII) for postoperative sepsis patients.
ABSTRACT Background Sleep disturbances have become increasingly prevalent in modern society. Research suggests that a deficiency magnesium (Mg) may contribute to sleep disturbances. This study aims investigate the association between daily Mg intake and self‐reported duration disorders using data from National Health Nutrition Examination Survey (NHANES). Methods The dataset includes participants five cycles (2009–2018) of NHANES. associations are analyzed weighted logistic regression....
Early complications increase in-hospital stay and mortality after intestinal obstruction surgery. It is important to identify the risk of postoperative early for patients with at a sufficiently stage, which would allow preemptive individualized enhanced therapy be conducted improve prognosis obstruction. A predictive model based on machine learning helpful diagnosis timely intervention. This study aimed construct an online calculator in surgery algorithms. total 396 undergoing from April...
Background: To investigate the effects of intraoperative application dexmedetomidine (Dex) on early gastrointestinal motility after laparoscopic resection colorectal cancer. Methods: In this prospective, randomized double-blind investigation, 60 patients who underwent cancer were randomly allocated to receive Dex (DEX group, n = 30) or saline (CON 30). DEX was loaded (1 μg/kg) before anesthesia induction and infused (0.3 μg/kg/h) during surgery. Time postoperative first flatus (FFL) feces...
The aim of this study was to test whether the implementation an enhanced recovery after surgery (ERAS) protocol for patients undergoing elective cesarean delivery has a positive impact on postoperative status in terms pain management, hospital stay, hospitalization costs, and adverse reactions. Patients who underwent were randomized into two groups - ERAS group control managed with traditional protocol, respectively. Compared group, had significantly fewer intraoperative nausea, visual...
BackgroundPostoperative nausea and vomiting (PONV) is a major problem after surgery. Even with double prophylactic therapy including dexamethasone 5-hydroxytryptamine-3 receptor antagonist, the incidence still high in many at-risk patients. Fosaprepitant, neurokinin-1 an effective antiemetic, but its efficacy safety combination antiemetic for preventing PONV remain unclear.MethodsIn this randomised, controlled, double-blind trial, 1154 participants at risk of undergoing laparoscopic...
Perioperative serum potassium levels are closely associated with postoperative clinical outcomes after gastrointestinal surgery. The aim of our retrospective study was to identify the prevalence and risk factors for preoperative hypokalemia (before pneumoperitoneum) evaluate influence on recovery function. In this study, patients scheduled laparoscopic colorectal resection from November 11 2014 October 20 2016, were considered inclusion. A blood level between 3.5 5.5 mmol/L defined as...
To investigate whether overexpression of Brahma-related gene-1 (Brg1) can alleviate lung injury induced by hepatic ischemia/reperfusion (HIR) and its precise mechanism.Cytomegalovirus-transgenic Brg1-overexpressing (CMV-Brg1) mice wild-type (WT) C57BL/6 underwent HIR. Lung histology, oxidative markers, antioxidant enzyme concentrations in the were assessed. The protein expression levels Brg1, nuclear factor erythroid 2-related 2 (Nrf2), heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase...
Aims: Perioperative acute kidney injury (AKI) resulting from renal ischemia reperfusion (IR) is not conducive to the postoperative surgical recovery. Our previous study demonstrated that reactive oxygen species (ROS) transmitted by gap junction (GJ) composed of connexin32 (Cx32) contributed AKI. However, precise underlying pathophysiologic mechanisms were largely unknown. This focuses on related ROS Cx32 responsible for AKI aggravation. Results: In a set in vivo studies, IR was found cause...
Abstract Background To investigate whether transmuscular quadratus lumborum block (TQLB) combined with oxycodone-based patient-controlled intravenous analgesia (PCIA) compared sufentanil-based could reduce postoperative pain and opioid consumption in patients undergoing laparoscopic hepatectomy. Methods Eighty hepatectomy surgery were randomly divided into Group S (Sufentanil for PCIA group), O (Oxycodone group) QO (transmuscular + oxycodone group). Primary outcome was Numerical Rating Scale...
Lidocaine alleviates propofol injection pain. However, whether lidocaine works through a local anesthetic effect at the site of intravenous or systemic on central nervous system remains unknown. This study aimed to determine pain-alleviating mechanism lidocaine.A randomized controlled study.A gastroscopy facility.The was divided into two parts. Part 1 involved 717 patients who were randomly assigned five groups. Groups PR, RL20, and RL40 received normal saline containing 20 40 mg lidocaine,...
Systemic inflammatory response syndrome (SIRS) is one of the severe postoperative complications in elderly patients and seriously affects their prognosis survival rate. Heretofore, there have been no reliable accurate methods to predict SIRS patients. The aim this study was determine whether increased preoperative hs-CRP/albumin ratio (CAR) associated with population. data aged ≥ 65 years who underwent general anesthesia two centers Third Affiliated Hospital Sun Yat-sen University between...
Purpose: We aimed to evaluate the effect of intravenous esketamine combined with dexmedetomidine as supplemental analgesia in reducing intraoperative visceral pain during elective cesarean section under spinal-epidural anesthesia (CSEA). Patients and Methods: A total 269 parturients scheduled for CSEA between May 2023 August were assessed. The randomly allocated receiving either infusion 0.3-mg/kg 0.5-μg/kg (group ED, n=76), D, or normal saline C, n=76) after umbilical cord clamping. primary...