A5100331076- Organ Transplantation Techniques and Outcomes
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Shoulder Injury and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Topic Modeling
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Extracellular vesicles in disease
- Cellular transport and secretion
- Transplantation: Methods and Outcomes
- Cancer-related molecular mechanisms research
- Adenosine and Purinergic Signaling
- Total Knee Arthroplasty Outcomes
- Microtubule and mitosis dynamics
- Anesthesia and Neurotoxicity Research
- Pancreatic and Hepatic Oncology Research
- Thyroid Disorders and Treatments
- Pancreatic function and diabetes
- Hip disorders and treatments
- Neuroendocrine Tumor Research Advances
Zhejiang University
2023
Tianjin Medical University General Hospital
2016-2022
Second Affiliated Hospital of Inner Mongolia Medical University
2022
Tianjin Medical University
2014-2022
Tianjin First Center Hospital
2021-2022
Third Affiliated Hospital of Sun Yat-sen University
2021
Sun Yat-sen University
2021
Emory University
2010
Hepatic ischemia-reperfusion injury (IRI) is an inevitable result of liver surgery. Steatotic livers are extremely sensitive to IRI and have worse tolerance. Ferroptosis considered be one the main factors organ IRI. This study aimed at exploring role ferroptosis in effect heme oxygenase-1-modified bone marrow mesenchymal stem cells (HO-1/BMMSCs) on steatotic its mechanism. An model a hypoxia reoxygenation (HR) hepatocytes (SHPs) were established. Rat BMMSCs extracted transfected with Ho1...
Early prediction of acute kidney injury (AKI) after liver transplantation (LT) facilitates timely recognition and intervention. We aimed to build a risk predictor post-LT AKI via supervised machine learning visualize the mechanism driving within assist clinical decision-making.Data 894 cases that underwent from January 2015 September 2019 were collected, covering demographics, donor characteristics, etiology, peri-operative laboratory results, co-morbidities medications. The primary outcome...
Background: The radiation oncology clinical practice involves many steps relying on the dynamic interplay of abundant text data. Large language models have displayed remarkable capabilities in processing complex information. But their direct applications specific fields like remain underexplored. Purpose: This study aims to investigate whether fine-tuning LLMs with domain knowledge can improve performance Task (1) treatment regimen generation, (2) modality selection (photon, proton,...
Recent studies suggest that the human Abelson helper integration site-1 ( AHI1 ) gene on chromosome 6 is associated with susceptibility to schizophrenia and autism, two common neuropsychological disorders depression symptoms. Mouse Ahi1 protein abundant in hypothalamus amygdala, which are important brain regions for controlling emotion. However, neuronal function of remains unclear. With Cre–loxP system, we created a mouse model selectively reduces expression cells. Mice deficiency show...
The endometrial regenerative cell (ERC) is a novel type of adult mesenchymal stem isolated from menstrual blood. Previous studies demonstrated that ERCs possess unique immunoregulatory properties in vitro and vivo, as well the ability to differentiate into functional hepatocyte-like cells. For these reasons, present study was undertaken explore effects on carbon tetrachloride (CCl4)-induced acute liver injury (ALI).An ALI model C57BL/6 mice induced by administration intraperitoneal injection...
Livers from donors after circulatory death (DCD) are inevitably exposed to a longer warm ischemic period, which might increase the incidence of postoperative bile duct complications. Bone marrow mesenchymal stem cells (BMMSCs) have tissue repair properties. The present study was aimed at exploring effect heme oxygenase-1- (HO-1-) modified BMMSCs (HO-1/BMMSCs) combined with normothermic machine perfusion (NMP) on injury DCD liver transplantation and revealing underlying mechanisms. Rat livers...
Abstract Background: Early prediction of acute kidney injury (AKI) after liver transplantation (LT) facilitates timely recognition and intervention. We aimed to build a risk predictor post-LT AKI via supervised machine learning visualize the mechanism driving within assist clinical decision-making. Methods: Data 894 cases that underwent from January 2015 September 2019 were collected, covering demographics, donor characteristics, etiology, peri-operative laboratory results, co-morbidities...
Aim To investigate the interactions between graft-to-recipient weight ratio (GWRWR) and other risk factors responsible for inferior allograft outcomes. Methods A total of 362 patients who received liver transplantation (LT) were enrolled. Indicators such as graft/recipient prognostic collected. Comparisons indicators survival analysis performed in groups categorized by GWRWR. Interactions large-for-size grafts (LFSGs) with graft macrosteatosis (MaS) evaluated terms relative excess caused...
Abstract Background: Liver transplantation (LT) represents the most effective treatment for many end-stage liver diseases. While donation after cardiac death (DCD) donor livers are used due to organ shortage, acute rejection (ACR) remains an important risk factor affecting survival of recipients following transplantation. Although immunosuppressive agents can be used, they associated with complications. Bone marrow mesenchymal stem cells (BMMSCs) in transplantation; however, there is limited...
Objective To study the role of CD11c+ F4/80- renal resident DCs in kidney ischemia reperfusion injury, and investigate underlining mechanism. Method The optimal diphtherotoxin (DT) dose was screened. C. FVB-Tg (Itgax-DTR/GFP) 57Lan/J (DTR/GFP) mice were intraperitoneally injected with 0, 8, 16, 24 ng/g weight DT, clearance rDC loss detected 18 h later. DTR/GFP DT PBS before bilateral models established. after reperfusion, samples harvested to perform histological analysis FACS...
Stem length and cross section are two key parameters that influence the stability longevity of metallic hip prosthesis in total arthroplasty (THA). In order to assess their stress fatigue behavior prosthesis, a series model with round‐shaped or drum‐shaped section, different stem lengths were created. These models analyzed under both static dynamic loading conditions finite element analysis, represents normal walking was used analysis. The on stem, cement, adjacent bone got, micromotion...
To evaluate residents in North China cognition level of iodine nutrition and their intention to individual status.From February 2019 June 2020, randomly selected six provinces cities north more than three or areas, then local investigators distributed questionnaires urban rural residents. The questionnaire was divided into parts: basic information, knowledge, status evaluation demand approaches.Finally, there are 740 were included. scores knowledge the subjects generally low, about 71.22%...
Background: Acute rejection (ACR) remains an important risk factor affecting the survival of recipients following liver transplantation (LT). Immunosuppressive agents are associated with many complications. Bone marrow mesenchymal stem cells (BMMSCs) used in treatment organ transplantation; however, there is limited colonization target organs and a short time systemic BMMSCs application.Methods: were isolated from rat bone modified adenovirus for heme oxygenase 1 (HO-1) gene. HO-1/BMMSCs...