A5100685778- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Kidney Stones and Urolithiasis Treatments
- Urinary Bladder and Prostate Research
- Optical Imaging and Spectroscopy Techniques
- Pelvic floor disorders treatments
- Regulation of Appetite and Obesity
- Asthma and respiratory diseases
- Pediatric Urology and Nephrology Studies
- Sexual function and dysfunction studies
- Photoacoustic and Ultrasonic Imaging
- Organ Transplantation Techniques and Outcomes
- Artificial Intelligence in Healthcare
- Prostate Cancer Diagnosis and Treatment
- Tendon Structure and Treatment
- Hormonal and reproductive studies
- Transplantation: Methods and Outcomes
- Ureteral procedures and complications
- Thermoregulation and physiological responses
- Bird parasitology and diseases
- Study of Mite Species
- Cancer, Hypoxia, and Metabolism
- Circadian rhythm and melatonin
- Insect and Pesticide Research
- Tissue Engineering and Regenerative Medicine
Hangzhou Hospital of Traditional Chinese Medicine
2025
Second Affiliated Hospital of Zhejiang University
2015-2025
Beijing Hua Xin Hospital
2020-2025
China Agricultural University
2022-2025
University of Macau
2024
Huazhong University of Science and Technology
2010-2024
Southern University of Science and Technology
2024
Nanjing University of Chinese Medicine
2021-2024
Tsinghua University
2024
State Key Laboratory of New Ceramics and Fine Processing
2024
The effect of hypoxia, induced by incubation under low (1%) oxygen tension or exposure to CoCl(2), on the expression and secretion inflammation-related adipokines was examined in human adipocytes. Hypoxia led a rapid substantial increase (greater than sevenfold 4 h 1% O(2)) hypoxia-sensitive transcription factor, HIF-1alpha, This accompanied major (up 14-fold) GLUT1 transporter mRNA level. (1% O(2) CoCl(2)) reduction threefold over 24 h) adiponectin haptoglobin levels; also decreased. No...
Abstract Acute Kidney Injury (AKI) is a significant medical condition characterized by the abrupt decline in kidney function.Low‐intensity pulsed ultrasound (LIPUS), non‐invasive therapeutic technique employing low‐intensity acoustic wave pulses, has shown promise promoting tissue repair and regeneration. A novel LIPUS system was developed evaluated rat AKI models, focusing on its effects glomerular filtration rate (GFR), blood urea nitrogen (BUN), serum creatinine (SCr), Notch1‐Akt‐eNOS...
The expression profile of a series adipokine genes linked to inflammation has been examined by quantitative PCR during the differentiation human preadipocytes adipocytes in primary culture, together with integrated effects TNF-alpha on these adipokines differentiated adipocytes. Expression encoding adiponectin, leptin, and haptoglobin was highly dependent, mRNA being undetectable predifferentiation level peaking 9-15 days postdifferentiation. Although angiotensinogen (AGT) monocyte...
The effect of hypoxia on the expression and secretion major adipokines by human preadipocytes has been examined. Hypoxia (1% O 2 ) led to an increase in HIF-1α transcription factor subunit cultured preadipocytes, as did incubation with mimetic CoCl . Leptin mRNA was essentially undetectable incubated under normoxia (21% ), but exposure 1% , or for 4 24 h resulted induction leptin gene (measured real-time PCR). Immunoreactive not detected medium from normoxic present hypoxic cells. stimulated...
Background Long noncoding RNAs (lncRNAs) are an important class of pervasive genes involved in a variety biological functions. They aberrantly expressed many types cancers. In this study, we described lncRNAs profiles 6 pairs human renal clear cell carcinoma (RCCC) and the corresponding adjacent nontumorous tissues (NT) by microarray. Methodology/Principal Findings With abundant varied probes accounting 33,045 LncRNAs our microarray, number that at certain level could be detected is 17157....
The clear cell renal carcinoma (ccRCC) microenvironment consists of many different types and structural components that play critical roles in cancer progression drug resistance, but the cellular architecture underlying gene regulatory features ccRCC have not been fully characterized. Here, we applied single-cell RNA sequencing (scRNA-seq) assay for transposase-accessible chromatin (scATAC-seq) to generate transcriptional epigenomic landscapes ccRCC. We identified tumor cell-specific...
Hypoxia modulates the production of key inflammation-related adipokines and may underlie adipose tissue dysfunction in obesity. Here we have examined effects hypoxia on glucose transport by human adipocytes. Exposure adipocytes to (1% O(2)) for up 24 h resulted increases GLUT-1 (9.2-fold), GLUT-3 (9.6-fold peak at 8 h), GLUT-5 (8.9-fold) mRNA level compared normoxia (21% O(2)). In contrast, there was no change GLUT-4, GLUT-10 or GLUT-12 expression. The rise accompanied a substantial increase...
Early prediction of acute kidney injury (AKI) after liver transplantation (LT) facilitates timely recognition and intervention. We aimed to build a risk predictor post-LT AKI via supervised machine learning visualize the mechanism driving within assist clinical decision-making.Data 894 cases that underwent from January 2015 September 2019 were collected, covering demographics, donor characteristics, etiology, peri-operative laboratory results, co-morbidities medications. The primary outcome...
Abstract Background Previous epidemiological observational studies have potentially associated psoriasis with bladder cancer, but the results are inconsistent, and causality remains unknown. The present study aimed to examine whether there causal associations between cancer using bidirectional two‐sample Mendelian randomization (MR) analysis. Materials Methods A MR analysis was conducted publicly available genome‐wide association (GWAS) data for individuals diagnosed cancer. inverse variance...
Hypoxia-signalling pathway PCR arrays were used to examine the integrated response of human adipocytes low O2 tension. Incubation in 1% for 24 h resulted no change expression 63 84 genes on arrays, a reduction 9 (including uncoupling protein 2) and increased 12 genes. Substantial increases (>10-fold) leptin, angiopoietin-like 4, VEGF GLUT-1 mRNA levels observed. The one gene, metallothionein-3 (MT-3), was dramatically (>600-fold) rapidly (by 60 min) by hypoxia. MT-3 gene also substantially...
Low-intensity extracorporeal shock wave therapy (Li-ESWT) is used in the treatment of erectile dysfunction, but its mechanisms are not well understood. Previously, we found that Li-ESWT increased expression brain-derived neurotrophic factor (BDNF). Here assessed underlying signaling pathways Schwann cells vitro and penis tissue vivo after nerve injury. The result indicated BDNF were significantly by injury, as (SCs, RT4-D6P2T) vitro. activated protein kinase RNA-like endoplasmic reticulum...
Abstract Background Pneumonia is the most frequently encountered postoperative pulmonary complications (PPC) after orthotopic liver transplantation (OLT), which cause high morbidity and mortality rates. We aimed to develop a model predict pneumonia in OLT patients using machine learning (ML) methods. Methods Data of 786 adult underwent at Third Affiliated Hospital Sun Yat-sen University from January 2015 September 2019 was retrospectively extracted electronic medical records randomly...
Previous clinical studies have demonstrated that Wumei Pill (WP), a traditional Chinese medicine formula, can effectively alleviate nocturnal asthma-related anxiety and improve nighttime symptoms. The therapeutic mechanism of WP may involve regulation inflammatory chemokines in peripheral blood. This is potentially linked to modulation the circadian clock gene ARNT-like protein-1 (Bmal1), but precise pathways underlying this interaction remain unclear, requiring further investigation. Bmal1...