A5039315692- Sexual function and dysfunction studies
- Urinary Bladder and Prostate Research
- Genital Health and Disease
- Pelvic floor disorders treatments
- Hormonal and reproductive studies
- Nerve injury and regeneration
- Tendon Structure and Treatment
- Circadian rhythm and melatonin
- Biochemical effects in animals
- Atherosclerosis and Cardiovascular Diseases
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Chemotherapy-induced organ toxicity mitigation
- Menopause: Health Impacts and Treatments
- Clinical Laboratory Practices and Quality Control
- Sphingolipid Metabolism and Signaling
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Adolescent Sexual and Reproductive Health
- Anesthesia and Neurotoxicity Research
- Medicinal Plant Pharmacodynamics Research
- Medicinal Plants and Bioactive Compounds
- Protease and Inhibitor Mechanisms
- Prenatal Substance Exposure Effects
- Aldose Reductase and Taurine
Agency for Science, Technology and Research
2024
Institute of High Performance Computing
2024
Sun Yat-sen University
2023
Fifth Affiliated Hospital of Sun Yat-sen University
2023
Henan Provincial People's Hospital
2023
Zhengzhou University
2023
Zunyi Medical University
2022-2023
Central South University
2010-2021
Third Xiangya Hospital
2008-2021
ORCID
2020-2021
Abstract Testicular germ cell tumours (TGCTs) rank as the most common malignancy in men aged 20‐34 years, and seminomas are type of TGCTs. As a crucial anti‐tumour agent with explicit toxicity, cisplatin may render resistance through intertwined mechanisms, even disease entities high curative ratio, such seminoma. Previously, we established cisplatin‐resistant seminoma TCam‐2 (TCam‐2/CDDP) cells showed that epigenetic regulations, non‐coding RNA (ncRNA) interactions, might orchestrate fate...
Clinical treatment of erectile dysfunction (ED) caused by cavernous nerve (CN) injury during pelvic surgery is difficult. Low-intensity pulsed ultrasound (LIPUS) can be a potential strategy for neurogenic ED (NED). However, whether Schwann cells (SCs) respond to LIPUS stimulation signals unclear. This study aims elucidate the signal transmission between SCs paracrine exosome (Exo) and neurons stimulated LIPUS, as well analyze role mechanisms exosomes in CN repair after injury.The major...
Low-intensity extracorporeal shock wave therapy (Li-ESWT) is used in the treatment of erectile dysfunction, but its mechanisms are not well understood. Previously, we found that Li-ESWT increased expression brain-derived neurotrophic factor (BDNF). Here assessed underlying signaling pathways Schwann cells vitro and penis tissue vivo after nerve injury. The result indicated BDNF were significantly by injury, as (SCs, RT4-D6P2T) vitro. activated protein kinase RNA-like endoplasmic reticulum...
MicroRNA (miRNA)-gene interactions are well-recognized as involved in the progression of almost all cancer types including prostate cancer, which is one most common cancers men. This study explored significantly dysregulated genes and miRNAs elucidated potential miRNA-gene regulatory network cancer. Integrative analysis normal transcriptomic data The Cancer Genome Atlas dataset was conducted using both differential expression weighted correlation (WGCNA). Thirteen (RRM2, ORC6, CDC45, CDKN2A,...
Chlorpyrifos (CPF), one of organophosphorus pesticides (OPs), is associated with developmental neurotoxicity. Inflammatory response closely related CPF-induced The present study aimed at exploring whether sub-toxic CPF exposure on neonatal rats results in neuroinflammation that mediated by HMGB1/TLR4/NF-κB signaling pathway the amygdala. were subcutaneously injected 5mg/kg for 4 consecutive days (postnatal day 11-14) or without HMGB1 inhibitor, glycyrrhizin. We assessed levels...
We previously identified TDRG1 (testis developmental related gene 1), a novel with exclusive expression in testis, promoted the proliferation and progression of cultured human seminoma cells through PI3K/Akt/mTOR signaling. As increasing evidence reveal that aberrant activation this signaling is involved cisplatin resistance. Then, study, we further explored whether regulated chemosensitivity TCam-2 to cisplatin. Our researches showed could regulate viability following treatment vitro...
Aim Stress urinary incontinence (SUI) is a significant health problem for women. Treatments employing muscle derived stem cells (MDSCs) may be promising approach to this prevalent, bothersome condition, but these treatments are invasive and require collection of from one site injection into another. It also unknown whether or not establish themselves function as in the target tissues. Alternatively, low‐intensity extracorporeal shock wave therapy (Li‐ESWT) non‐invasive has shown positive...
The purpose of this study is to investigate the prevalence rate and risk factors depression in outpatients who were diagnosed with PE. Therefore, between September 2009 2011, 1801 at andrology clinics enrolled consented participate our survey by completed a verbal questionnaire. It included following: (1) demographic data (e.g., age, body mass index), (2) PE duration, medical history, sexual (3) self-estimated intravaginal ejaculatory latency times, (4) Zung Self-rating Depression Scale...
Objectives To evaluate the therapeutic effect of once‐weekly low‐intensity extracorporeal shock wave therapy (Li‐ ESWT ) on underactive bladder ( UAB in streptozotocin STZ )‐induced diabetic rat model. Materials and Methods In all, 36 female Sprague–Dawley rats were divided into three groups: normal control NC ), diabetes mellitus DMC DM with Li‐ ). The two groups received an intraperitoneal 60 mg/kg injection to induce . was applied toward pelvis starting 4 weeks after administration...
AIM: Accumulated evidence indicates that neurotrophin deregulations, oxidative stress injury and mitochondrial dysfunction have been involved in bipolar disorder (BD);however, their real roles BD are unclear. Investing the possible interaction between three systems is worthwhile understanding this complex process. Methods: We measured plasma Brain-derived neurotrophic factor (BDNF) level, leukocytes DNA copy number (mtDNAcn), activity of antioxidant enzymes patients (n = 97) healthy controls...
Cavernous nerve injury-induced erectile dysfunction caused by pelvic surgery or trauma is refractory to conventional medications and required an alternative treatment. Low-intensity pulsed ultrasound a noninvasive mechanical therapy that promotes regeneration.To investigate the therapeutic effect potential mechanism of low-intensity in treatment neurogenic dysfunction.Thirty rats were randomly divided into sham-operated group, bilateral cavernous injury + group. The function was assessed 3...
Abstract It is unclear whether membrane vitamin D receptor (mVDR) exists on the macrophage or mVDR associated with lipopolysaccharide (LPS) tolerance. Herein, we report that interfering caveolae and caveolae-dependent lipid rafts inhibited formation of LPS VDR was detected as co-localized molecular markers. cell its level higher in LPS-tolerant cells than only treatment cells. Anti-VDR antibodies could abolish effect artesunate (AS) to reverse tolerance, wild-type peptides (H397 H305) VDR,...
The result of nerve growth factor (NGF) actions depends upon the cells in which it signals. To define how signaling is influenced by cellular context, would be useful to examine committed different fates or a single type at developmental stages. Interest NGF on neurons central nervous system led us GT1-1 cells, an immortalized hypothalamic cell line. demonstrated neuronal properties but were unresponsive and other neurotrophins. Through transfection, trkA expression conferred leading...
Objectives To investigate the feasibility of Zucker fatty ( ZF ) rat as a model for research in to obesity‐associated erectile dysfunction OAED and determine effect low‐intensity extracorporeal shockwave therapy (Li‐ ESWT on penile tissue function these rats. Materials methods Eight new‐born male lean ZL group) rats ZUC ‐ Lepr fa 186) 16 185) were injected with 5‐ethynyl‐2’‐deoxyuridine (EdU) at birth identify monitor endogenous stem cells. Insulin tolerance testing was performed 10 weeks...
Introduction Cisplatin (cis‐diamminedichloroplatinum II, CDDP), a drug widely used for cancer worldwide, may affect erectile function, but its side effects have not received enough attention. To investigate the effect of CDDP on function and possible mechanism. Methods Sprague−Dawley rats were intraperitoneally administered (CDDP group) or same volume normal saline (control group). Erectile was evaluated after one-week washout. Then, histologic changes in corpus cavernosum cavernous nerve...
Aim To evaluate the prevalence of mild cognitive impairment (MCI) within empty‐nest older adults population in poor rural areas Hunan province China, and to explore effects resilience affective balance on functioning this specific population. Methods A cross‐sectional, multistage, random cluster survey was administered participants from March 2013 December 2014 province. There were a total 1164 participants. These who residing The data collected two stages. In stage 1, Montreal Cognitive...
Abstract Background We have designed a patient‐based real‐time quality control (PBRTQC) procedure to detect analytical shifts and review trends of measurement procedures. Methods All the nine months' patient results total thyroxine (TT4), triiodothyronine (TT3), free (FT4), (FT3), thyrotropin (TSH) measured by three identical analyzers were divided into groups according source inpatient patients, outpatient healthy people. The data in each group truncated optimized Box‐Plot method normalized...
To investigate the possibility and mechanism of microenergy acoustic pulses (MAP) for activating tissue resident stem/progenitor cells within pelvic urethral muscle possible mechanism.The female Zucker Lean Fatty rats were randomly divided into four groups: ZL control, ZLMAP, ZF ZFMAP. MAP was applied at 0.033 mJ/mm2 , 3 Hz 500 pulses, urethra floor muscles each rat then harvested cell isolation flow cytometry assay. Freshly isolated analyzed by Pax-7, Int-7α, H3P, EdU expression. Meanwhile,...
This study aimed to explore the possibility of miR-423-5p modified adipose-derived stem cell (ADSCs) therapy on streptozotocin (STZ)-induced diabetes mellitus erectile dysfunction (DMED) rats. MiR-423-5p was knocked down in ADSCs. ADSCs, NC-miR-ADSCs and miR-ADSCs were co-cultured with human umbilical vein endothelial cells (HUVECs). Normal high glucose media supplemented. The supernatant HUVECs collected for assessment eNOS VEGFa expression, proliferation, apoptosis. ADSCs or exhibited...