A5100424383- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Genetic and phenotypic traits in livestock
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Extracellular vesicles in disease
- Cancer Genomics and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Reproductive Physiology in Livestock
- Kruppel-like factors research
- Reproductive Biology and Fertility
- RNA Interference and Gene Delivery
- Lipid metabolism and biosynthesis
- Nuclear Receptors and Signaling
- Biomedical Text Mining and Ontologies
- Genomic variations and chromosomal abnormalities
- Microtubule and mitosis dynamics
- Angiogenesis and VEGF in Cancer
- Antimicrobial Resistance in Staphylococcus
- Meat and Animal Product Quality
- Single-cell and spatial transcriptomics
- Biocrusts and Microbial Ecology
- Fuel Cells and Related Materials
Southwest Minzu University
2011-2024
Anhui University of Science and Technology
2024
Anhui University of Technology
2024
Chengdu University of Traditional Chinese Medicine
2023
Nantong University
2022
North China University of Science and Technology Affiliated Hospital
2022
Third Hospital of Changsha
2022
Hunan Provincial People's Hospital
2020
Changzhou No.2 People's Hospital
2015-2020
Nanjing Medical University
2012-2020
Our previous studies have shown that microRNA-383 (miR-383) is one of the most down-regulated miRNA in TGF-β1-treated mouse ovarian granulosa cells (GC). However, roles and mechanisms miR-383 GC function during follicular development remain unknown. In this study, we found was mainly expressed oocytes follicles. Overexpression enhanced estradiol release from through targeting RNA binding motif, single stranded interacting protein 1 (RBMS1). inhibited RBMS1 by affecting its mRNA stability,...
Background Non-small cell lung cancer (NSCLC) is a leading cause of death worldwide. Early diagnosis essential for improvements prognosis and survival the patients. Currently, there no effective biomarker available in clinical settings early detection cancer. Altered expressions many types including NSCLC stable existence plasma make microRNAs (miRNAs) group potentially useful biomarkers assessments patients with NSCLC. Objectives To evaluate potential values miRNAs as blood-based Methods...
Blood–brain barrier (BBB) disruption plays a critical role in brain injury induced by cerebral ischemia, and preserving BBB integrity during ischemia could alleviate injury. We examined the of miR-130a ischemic using models rat middle artery occlusion cell oxygen–glucose deprivation. found that significantly increased microRNA-130a (miR-130a) level was predominantly from microvascular endothelial cells. Antagomir-130a, an antagonist miR-130a, attenuate edema, lower permeability, reduce...
Background Genome-wide gene expression profile using deep sequencing technologies can drive the discovery of cancer biomarkers and therapeutic targets. Such efforts are often limited to profiling signature either mRNA or microRNA (miRNA) in a single type cancer. Methodology Here we provided an integrated analysis genome-wide miRNA profiles three different genitourinary cancers: carcinomas bladder, kidney testis. Principal Findings Our results highlight general cancer-specific roles several...
// Xiaodan Fu 1, 2 , Yimin Li Ayesha Alvero 3 Juanni Qihui Wu Qing Xiao Yulong Peng Yongbin Hu Xiang Wenguang Yan 5 Ke Guo 6 Wenjuan Zhou 7 Yong Wang 8 Junwen Liu 9 Yu Zhang 4 Gil Mor Jifang Wen Gang Yin 1 Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China School Basic Medical Sciences, Obstetrics, Gynecology and Reproductive Immunology Unit, Yale University Medicine, New Haven, CT, USA Gynecology, Rehabilitation, The Third Internal...
MicroRNA (miRNA)-gene interactions are well-recognized as involved in the progression of almost all cancer types including prostate cancer, which is one most common cancers men. This study explored significantly dysregulated genes and miRNAs elucidated potential miRNA-gene regulatory network cancer. Integrative analysis normal transcriptomic data The Cancer Genome Atlas dataset was conducted using both differential expression weighted correlation (WGCNA). Thirteen (RRM2, ORC6, CDC45, CDKN2A,...
Abstract Intramuscular fat refers to the adipose tissue distributed in muscle. It is an important indicator that affects quality of goat meat, and can directly affect tenderness flavor meat. Our previous study revealed mRNA may be crucial for intramuscular deposition during growth; however, how microRNAs (miRNAs) are involved process largely unclear. In present study, a total 401 known miRNAs 120 novel miRNAs, including 110 differentially expressed (DE) were identified among longissimus...
MicroRNAs have been implicated in the regulation of gene expression various biological processes a post-transcriptional manner under physiological and pathological conditions including host responses to viral infections. The 2009 pandemic H1N1 influenza virus is an emerging reassortant strain swine, human bird that can cause mild severe illness even death. To further understand molecular pathogenesis virus, we profiled cellular microRNAs lungs from BALB/c mice infected with wild-type...
Background: Preoperative 5-fluorouracil (5-FU)-based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, CRC cells often develop chemoradiation resistance (CRR). Recent studies have shown that long non-coding RNA (lncRNA) plays critical roles in myriad of biological processes and human diseases, as well chemotherapy resistance. Since the lncRNAs 5-FU-based CRR remain unknown, they were investigated this study. Materials Methods: A concurrent cell...
Intramuscular fat (IMF) content and fatty acid composition of longissimus dorsi muscle (LM) change with growth, which partially determines the flavor nutritional value goat (Capra hircus) meat. However, unlike cattle, little information is available on transcriptome-wide changes during different postnatal stages in small ruminants, especially goats. In this study, sequencing reads LM tissues collected from kid, youth, adult period were mapped to genome. Results showed that out total 24 689...
MicroRNAs (miRNAs) are posttranscriptional modulators of gene expression that play important roles in various biological processes. Spermatogenesis is a highly regulated process which diploid spermatogonia eventually differentiate into haploid spermatozoa. In this study, we identified four differentially expressed miRNAs between two premeiotic male germ cells, made predictions about their putative targets, and confirmed cyclin T2 (Ccnt2) as direct target miR‐15a. We also report miR‐15a...
Abstract Soil microbial communities have been considered indicators of soil quality and fertility changes in restored ecosystems. Little is known, however, about how these change over time after restoration terms activity, structure, diversity. We evaluated the bacterial 4‐, 8‐, 12‐year‐old Elymus nutans revegetated grasslands located Qinghai–Tibetan Plateau. diversity composition significantly changed 8‐ compared with 4‐year‐old grassland. Surprisingly, transitioned from Proteobacteria‐...
Goats are popular in China because of their superior meat quality, delicate flesh, and unique flavor. Long noncoding RNAs (lncRNAs) play important roles transcriptional post-transcriptional regulation gene expression. However, the effects lncRNAs on adipocyte differentiation goat has not been fully elucidated yet. In this investigation, we performed RNA-Seq analysis intramuscular subcutaneous adipocytes from Jianzhou Daer before after differentiation, including both preadipocytes (IMPA) vs....
Physicochemical properties, bacterial communities, and volatile compounds of mutton sausage produced from Jianzhou Big-Eared goat meat during natural ripening were investigated. Firmicutes Bacteroidetes accounted for over 66% all operational taxonomic units (OTUs) throughout the whole process, with Lachnospiraceae _NK4A136_group Staphylococcus as predominant genus early later periods, respectively. The evolution microbial composition became less rich diverse. uncultured bacterium,...
Abstract Intramuscular lipid deposition is important for meat quality improvement. microRNAs and their target mRNAs provide a new approach studying the mechanism of fat deposition. The present study aimed to investigate effect miR-130b duplex (miR-130b-5p, miR-130b-3p) its gene KLF3 in regulating goat intramuscular adipocyte differentiation. Goat preadipocytes were isolated from 7-d-old male Jianzhou big-ear goats identified by Oil red O staining after differentiation induction. miR-130b-5p...
Background: Clear cell renal carcinoma (ccRCC) is the most common type of carcinoma, accounting for approximately 70% all RCC cases. Cuproptosis, a novel mechanism death, may be potential target intervention in tumor development. Methods: Cuproptosis-related prognostic lncRNAs were identified by co-expression analysis and univariable Cox regression. Five lncRNA profiles obtained LASSO regression analysis, model with high accuracy was constructed to assess prognosis ccRCC patients based on...
Introduction Ocular abnormalities and the development of retinal vasculature may cause postnatal retinopathy. In past decade, tremendous progress has been made in identifying mechanisms that regulate retina vasculature. However, means regulating embryonic hyaloid is largely unknown. This study aims to determine whether how andrographolide regulates development. Methods Murine retinas were used this study. Whole mount isolectin B4 (IB4) staining, hematoxylin eosin (H&E)...
Follicle-stimulating hormone (FSH) and luteinizing (LH) have a central role in follicle growth maturation, but no clear differences between breeds with different ovulation rates been found. Therefore, this study investigated mRNA expression of FSHβ, LHβ, FSH receptor (FSHR), LH (LHR), estrogen receptor-β (ERβ) genes prolific Lezhi black (LB) goats nonprolific Tibetan (TB) by real-time PCR. Follicles pituitaries were recovered from at 12–24 h after onset estrus. Real-time PCR analysis...
Goats are an important livestock and goat meat is essential to local people. The intramuscular fat (IMF) content has a great influence on the quality of meat. preadipocytes differentiation closely related IMF deposition; however, its potential regulatory mechanisms remain unclear. CircRNAs were revealed be involved in multiple biological progressions. In this study, we took primary preadipocyte (GIMPA) as study model verify function mechanism chi-circ_0006511, which was abundant up-regulated...