A5102220941- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Organic Electronics and Photovoltaics
- Perovskite Materials and Applications
- Cancer-related gene regulation
- Conducting polymers and applications
- Plant-Microbe Interactions and Immunity
- Microbial Natural Products and Biosynthesis
- Circular RNAs in diseases
- Plant tissue culture and regeneration
- Fungal Biology and Applications
- Plant Virus Research Studies
- Phytochemical Studies and Bioactivities
- Nematode management and characterization studies
- Supramolecular Self-Assembly in Materials
- X-ray Diffraction in Crystallography
- Trace Elements in Health
- Genetic Associations and Epidemiology
- Chemical Analysis and Environmental Impact
- AI in cancer detection
- Molecular Biology Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Forensic and Genetic Research
- Forensic Entomology and Diptera Studies
Jiangxi University of Science and Technology
2024
First Affiliated Hospital of Jinan University
2022-2024
Central South University
2013-2024
China Tobacco
2019-2024
Linyi People's Hospital
2019
Xiangya Hospital Central South University
2016-2017
Sichuan University
2015
Abstract Oxaliplatin is widely used in the frontline treatment of colorectal cancer (CRC), but an estimated 50% patients will eventually stop responding to due acquired resistance. This study revealed that diminished MEIS1 expression was detected CRC and harmed survival patients. impaired cell viabilities tumor growth mice enhanced sensitivity oxaliplatin by preventing DNA damage repair. Mechanistically, resistance following suppression critically dependent on FEN1 expression. Subsequently,...
: Epithelial ovarian cancer (EOC) is one of the most lethal malignancies in women worldwide. Many studies showed transcription factor SNAI2-induced Epithelial-Mesenchymal Transition (EMT) through inhibiting E-cadherin (E-cad) expression. Our previous study reported that miR-222-3p was an important tumor-suppressive miRNA for EOC development and dissemination. The present aimed to acquire a deeper mechanistic understanding role regulation might contribute improving current anti-metastasis...
Paenibacillus polymyxa is an important member of the plant growth-promoting rhizobacteria. P. YC0136 inoculation had beneficial effect on growth promotion and biological control tobacco (Nicotiana tabacum L.) under field conditions. This study aimed to reveal mechanisms strain YC0136. In growth-promotion assays, height was increased by 8.42% 8.25% at 60 90 days, respectively, after with Strain also promoted accumulation biomass in varying degrees. Following YC0136, 3,525 4,368 genes were...
High-purity solanesol can be used for pharmaceutical applications, but the current method purifying has high cost and difficult continuous operation, use of molecular imprinting to purify natural products is a hot research topic research. Solanesol molecularly imprinted polymers were synthesized via emulsion polymerization first time. The morphology SSO-MIPs was observed with scanning electron microscope, effects synthesis time, initiator dosage, functional monomer cross-linking agent dosage...
// Xiaodan Fu 1, 2 , Yimin Li Ayesha Alvero 3 Juanni Qihui Wu Qing Xiao Yulong Peng Yongbin Hu Xiang Wenguang Yan 5 Ke Guo 6 Wenjuan Zhou 7 Yong Wang 8 Junwen Liu 9 Yu Zhang 4 Gil Mor Jifang Wen Gang Yin 1 Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China School Basic Medical Sciences, Obstetrics, Gynecology and Reproductive Immunology Unit, Yale University Medicine, New Haven, CT, USA Gynecology, Rehabilitation, The Third Internal...
Organic solar cells (OSCs) could benefit from the ternary bulk heterojunction (BHJ), a method that allows for fine-tuning of light capture, cascade energy levels, and film shape, in order to increase their power conversion efficiency (PCE). In this work, third components PM6:Y6 PM6:BTP-eC9 BHJs are set four star-shaped unfused ring electron acceptors (SSUFREAs), i.e., BD-IC, BFD-IC, BD-2FIC, BFD-2FIC, facilely synthesized by direct C–H arylation. The SSUFREAs all show complete complementary...
Two novel 3-decalinoyltetramic acid (3DTA) derivatives, namely fusarisetins C and D (1 2), four known derivatives (3-6) were isolated from the marine-derived fungus Fusarium equiseti D39. Their structures determined by spectroscopic data, vibrational circular dichroism (VCD) calculations, X-ray crystallography. Compound 2 was identified as first fusarisetin to possess an unprecedented carbon skeleton with a tetracyclic ring system comprised of decalin moiety (6/6) tetramic moiety. A...
The mortality rate of ovarian cancer is the highest among gynaecological cancers, primarily due to metastatic symptoms. Recent studies have shown that HOX genes are crucial in tumour progression, but underlying mechanisms remain unclear. Here, HOXC10 expression was examined tissues. function metastasis investigated vitroand via intraperitoneal injection vivo. A total 158 patients with adequate records were enrolled for analysis. associated and poor prognosis cancer. In vitro, overexpression...
Cervical cancer is the second most deadly gynecological tumor worldwide. MicroRNAs (miRNAs) play very important roles in oncogenesis and progression. The mechanism of post-transcription regulation WTX gene still unknown. A series differential miRNAs were discovered by microarray analysis comparing three pairs primary cervical specimens their relapsed tumors from patients. Quantitative reverse transcriptase PCR (qRT-PCR), Western Blot (WB) Immunohistochemistry (IHC) was used to detect...
Amplification of the 11q13.3 locus has been observed in various tumors. This study sought to determine correlation gene amplification at with immune status and survival breast cancer.Amplification was characterized by analyzing a publicly available database from cBioPortal platform (TCGA). The amplified genes cell infiltration cancer further analyzed using TIMER2.0 platform. Immunohistochemical staining used expression levels Cyclin D1 (CCND1), Fas-associated death domain (FADD) P53 156...
Abstract Chemotherapeutic drugs currently used in clinical settings have high toxicity, low specificity, and short half‐lives. Herein, polypyrrole‐based anticancer drug nanocapsules were prepared by tailoring the size of nanoparticles with a template method, controlling release means an aromatic imine, increasing nanoparticle stability through PEGylation, improving tumor‐cell selectivity folate mediation. The characterized TEM dynamic light scattering. α‐Folate receptor expression levelsof...
The aim of the present study was to measure expression microRNA (miR)-146a in liver tissues, peripheral blood mononuclear cells (PMBC) and serum from patients with Hepatitis B either fibrosis or cirrhosis, as well determine regulatory mechanism miR-146a. A total 36 25 hepatitis cirrhosis admitted Linyi People's Hospital (Shandong, China) between June 2012 February 2016 were included study. Reverse transcription-quantitative polymerase chain reaction performed miR-146a interleukin (IL)-6 mRNA...
Abstract Aspergillus genus is a key component in fermentation and food processing. However, sterigmatocystin (STE)—a mycotoxin produced by several species of —limits the use some (such as versicolor , inflatus parasiticus ) because its toxicity carcinogenicity. Here, we engineered an STE‐free strain based on genome mining techniques. We sequenced assembled D5 (34.52 Mb), which identified 16 scaffolds 54 biosynthetic gene clusters (BGCs). silenced cytochrome P450 coding genes STC17 STC27...
Budding uninhibited by benzimidazole 1 (BUB1) is a highly conserved serine/threonine kinase, showing prominent importance for proper function during mitosis. However, little known about
Bacillus velezensis DSYZ is a plant growth-promoting rhizobacterium with the capacity to control fungal pathogens. It was isolated from rhizosphere soil of garlic. Here, we present complete genome sequence B. DSYZ. Several gene clusters that are related biosynthesis antimicrobial compounds were predicted.
In this work, three conjugated oligomeric building blocks (BDD2, BDD3, and BDD4) containing respectively two, three, four 1,3-bis(4-(2-ethylhexyl)thiophen-2-yl)-5,7-bis(2-alkyl)benzo[1,2-c:4,5-c′]dithiophene-4,8-dione (BDD) units with conjugation lengths that increase continuously were facilely produced in a single pot of direct C–H arylation (DACH). The integration the above BDD derivatives BDT produces polymers steadily elongated (i.e., PB(DB)2-T2F, PB(DB)3-T2F, PB(DB)4-T2F) as series...