A5101910740- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Signaling Pathways in Disease
- Cancer, Hypoxia, and Metabolism
- Plant-based Medicinal Research
- Food Quality and Safety Studies
- Coagulation and Flocculation Studies
- Educational Reforms and Innovations
- Traumatic Brain Injury and Neurovascular Disturbances
- Mechanisms of cancer metastasis
- Morinda citrifolia extract uses
- Traditional Chinese Medicine Analysis
- Cancer and biochemical research
- Mobile Agent-Based Network Management
- Phytochemical compounds biological activities
- Cancer Research and Treatments
- IPv6, Mobility, Handover, Networks, Security
- Neuroinflammation and Neurodegeneration Mechanisms
- Caveolin-1 and cellular processes
- Education and Work Dynamics
- Advanced Algorithms and Applications
- Macrophage Migration Inhibitory Factor
Shaoyang University
2012-2024
Central South University
2015-2024
China Jiliang University
2021-2024
Henan Normal University
2023
Hunan Normal University
2021
The Affiliated Yongchuan Hospital of Chongqing Medical University
2013
Chongqing Medical University
2013
Guangxi Normal University
2007-2010
Chinese Academy of Medical Sciences & Peking Union Medical College
2007
Fu Wai Hospital
2007
Abstract Neuroinflammation is central to the pathology of traumatic brain injury (TBI). Xuefu Zhuyu decoction (XFZY) an effective traditional Chinese medicine treat TBI. To elucidate its potential molecular mechanism, this study aimed demonstrate that XFZY functions as anti-inflammatory agent by inhibiting PI3K-AKT-mTOR pathway. Sprague-Dawley rats were exposed controlled cortical impact produce a neuroinflammatory response. The treatment groups received (9 g/kg and 18 g/kg), Vehicle group...
: Epithelial ovarian cancer (EOC) is one of the most lethal malignancies in women worldwide. Many studies showed transcription factor SNAI2-induced Epithelial-Mesenchymal Transition (EMT) through inhibiting E-cadherin (E-cad) expression. Our previous study reported that miR-222-3p was an important tumor-suppressive miRNA for EOC development and dissemination. The present aimed to acquire a deeper mechanistic understanding role regulation might contribute improving current anti-metastasis...
MicroRNAs (miRNAs) play an important role in cancer development. In our study, miR-590-5p is found to be upregulated the examined renal cell carcinoma (RCC) lines. PBRM1 acts as tumor suppressor RCC, and its downregulation associated with increased proliferation aggressive behavior RCC. We confirmed that was a direct target of miR-590-5p. could regulate mRNA protein expressions clear (ccRCC) ACHN 786-O cells. Downregulation miR-590-5p, which resulted PBRM1, inhibited invasion ccRCC...
The mortality rate of ovarian cancer is the highest among gynaecological cancers, primarily due to metastatic symptoms. Recent studies have shown that HOX genes are crucial in tumour progression, but underlying mechanisms remain unclear. Here, HOXC10 expression was examined tissues. function metastasis investigated vitroand via intraperitoneal injection vivo. A total 158 patients with adequate records were enrolled for analysis. associated and poor prognosis cancer. In vitro, overexpression...
Xue Fu Zhu Yu Decoction, a famous formula that has been used for treating many blood stasis-caused diseases centuries, comprises 11 kinds of traditional Chinese medicines. A convenient, efficient, and rapid analytical method was developed to simultaneously determine the major compounds in this decoction. An ultra-high performance liquid chromatography with hybrid ion trap time-of-flight mass spectrometry rapidly separate detect constituents Using technique, we identified or tentatively 34...
Abstract Xuefu Zhuyu Decoction (XFZYD) is a traditional Chinese medicine prescription used for the clinical treatment of traumatic brain injury (TBI). The purpose this work was to develop sensitive and rapid UHPLC–MS/MS method simultaneously study pharmacokinetics nimodipine eight components XFZYD, namely, amygdalin, hydroxysafflor yellow A, rutin, liquiritin, narirutin, naringin, neohesperidin saikosaponin in rats with without TBI. Multiple reaction monitoring highly selective detection...
Security analysis of ad hoc routing protocols in an adversarial environment is a challenging task. The paper utilizes Event-B to model and verify the Secure Routing Protocol (SRP), secure on-demand source protocol. expected goal find correct routes. Thus generic definition for determining correctness discovered routes was proposed paper. presents system assumptions requirements that are required be implemented model. gradually introduces dynamic network topology, operations various route...
Abstract Purpose Pancreatic cancer(PC) is a common cancer with high lethality and low survival rate. Autophagy involved in the biological process of PC. Thus, we intended to explore function autophagy-related long noncoding RNA signature for assessment Methods Based on 10 lncRNAs, prognostic model was attained through univariate multivariate Cox regression analysis. Subsequently, relationship network lncRNAs crystallized co-expression Sankey diagram. Survival analysis ROC curve were used...
"Principles of Database System" is an attempt ideological and political course which incorporates elements the core values socialism into course. This can make up lack factors in professional courses get closer to actuality educational targets, has far-reaching significance for students' theoretical learning practical operation. Therefore, this research starts from Systems" improve motivation, patriotism, scientific spirit, noble quality. We propose a novel teaching mode combining education...
Objective To study the inhibition activity of volatile oil from Mappianthus iodoies on SPC-A-1 and BEL-7402 cancer cells.Methods The in iodoie was extracted by SFE-CO2.MTT assay employed to test antitumor effect two kinds malignant tumor cell lines,with IC50 applied evaluate degree activity.Results When dose 200 μg/ml,the ratios excess 50％,the 169.54,695.21 μg/ml respectively.Conclusion Volatile SFE-CO2 has obvious cells. Key words: Mappianthus iodoies; oil; MTT; Inhibition