A5101930808- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Renal cell carcinoma treatment
- Renal and related cancers
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Neuroscience of respiration and sleep
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Mesenchymal stem cell research
- Single-cell and spatial transcriptomics
- Genomics and Chromatin Dynamics
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- S100 Proteins and Annexins
- Inhalation and Respiratory Drug Delivery
- Angiogenesis and VEGF in Cancer
- Fibroblast Growth Factor Research
Vanderbilt University Medical Center
2019-2024
Xiangya Hospital Central South University
2016-2022
Central South University
2016-2022
Zhangzhou Municipal Hospital of Fujian Province
2018
Fujian Medical University
2018
Zhujiang Hospital
2015
Southern Medical University
2015
University of Oklahoma Health Sciences Center
2008
Medical University of South Carolina
1999-2001
Abstract Neuroinflammation is central to the pathology of traumatic brain injury (TBI). Xuefu Zhuyu decoction (XFZY) an effective traditional Chinese medicine treat TBI. To elucidate its potential molecular mechanism, this study aimed demonstrate that XFZY functions as anti-inflammatory agent by inhibiting PI3K-AKT-mTOR pathway. Sprague-Dawley rats were exposed controlled cortical impact produce a neuroinflammatory response. The treatment groups received (9 g/kg and 18 g/kg), Vehicle group...
PTEN plays an essential role in tumorigenesis and both its mutation inactivation can influence proliferation, apoptosis, cell cycle progression tumor cells. However, the precise of lung cancer cells has not been well studied. To address this, we have generated adenocarcinoma A549 overexpressing wild-type or mutant as expressing a siRNA directed toward endogenous . Overexpression profoundly inhibited promoted caused arrest at G1, downregulated p-AKT, decreased expression telomerase protein...
// Jian Xiao 1 , Xiaoxiao Lu Xi Chen 2 Yong Zou Aibin Liu 3 Wei Li 4 Bixiu He Shuya 5 and Qiong Department of Geriatrics, Respiratory Medicine, Xiangya Hospital Central South University, Changsha 410008, China Clinical Laboratory, Biochemistry & Biology, University China, Hengyang 421001, Correspondence to: Chen, email: qiongch@163.com Keywords: lung cancer, adenocarcinoma, squamous cell carcinoma, biomarker, prognosis Received: January 02, 2017 Accepted: March 29, Published: May 03,...
Abstract The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway has been identified as an important in renal cell carcinoma (RCC). We have reported a nonsense mutation PIK3R1 , which encodes the regulatory subunit of PI3K, metastatic RCC (mRCC), while was absent corresponding primary (pRCC). To identify function RCC, we examined its expression normal kidney, pRCC and mRCC by immunohistochemistry real-time polymerase chain reaction. significantly decreased further reduced...
Background— Left atrial–esophageal fistula is a serious and poorly understood complication of catheter ablation atrial fibrillation. The purpose this study was to (1) develop canine model esophageal injury left atrial-esophageal after applications forward-firing high-intensity focused ultrasound (HIFU) side-firing unfocused (SFU); (2) examine the relationship temperature (Eso-temp); (3) evolution injury/healing. Methods Results— Twenty dogs were studied. After transeptal puncture, HIFU...
Bacterial lipopolysaccharide (LPS) contributes to airway inflammation and mucus hypersecretion in chronic inflammatory diseases, such as obstructive pulmonary disease (COPD) cystic fibrosis (CF). Neutrophil extracellular traps (NETs) are meshworks composed of DNA fibers antimicrobial proteins. Although NET formation has been detected COPD CF patients, how NETs contribute these diseases is poorly understood. This study was performed clarify the effects mechanisms action hypersecretion. We...
We retrospectively collected data from a large sample size of population and explore the relationship between neutrophil-lymphocyte ratio (NLR) adverse outcomes, assessed clinical prognostic utility NLR in patients with chronic obstructive pulmonary acute exacerbation (AECOPD). reviewed 3 years medical case records, 622 were identified including 48 died 574 alive. Compared alive group, group had significantly elevated neutrophils, lymphocyte, level (P<0.001). The high-sensitive C-protein was...
According to recent research, Ras homolog gene family member C (RhoC) is confirmed have a powerful regulatory effect on cell motility mediated by the cytoskeleton, and this process closely associated with tumor invasion metastasis. In addition, epithelial-mesenchymal transition (EMT) which causes cytoskeleton rearrangement, also plays pivotal role in metastasis.Consequently, present study, we aimed ascertain whether RhoC has an EMT induced TGF-β1 lung adenocarcinoma cells promotes mediating...
Lung adenocarcinoma (LUAD) is the predominant type of lung cancer in U.S. and exhibits a broad variety behaviors ranging from indolent to aggressive. Identification biological determinants LUAD behavior at early stages can improve existing diagnostic treatment strategies. Extracellular matrix (ECM) remodeling cancer-associated fibroblasts play crucial role regulation aggressiveness there growing need investigate their determination stages. We analyzed tissue samples isolated patients with...
Purpose. To establish an effective and accurate prognostic nomogram for lung adenocarcinoma (LUAD). Patients Methods. 62,355 LUAD patients from 1975 to 2016 enrolled in the Surveillance, Epidemiology, End Results (SEER) database were randomly equally divided into training cohort (n = 31,179) validation 31,176). Univariate multivariate Cox regression analyses screened predictive effects of each variable on survival. The concordance index (C-index), calibration curves, receiver operating...
Background Lung cancer is the leading cause of death worldwide, with poor survival despite recent therapeutic advances. A better understanding complexity tumor microenvironment needed to improve patients’ outcome. Methods We applied a computational immunology approach (involving immune cell proportion estimation by deconvolution, transcription factor activity inference, pathways and scores estimations) in order characterize bulk transcriptomics 62 primary lung adenocarcinoma (LUAD) samples...
To investigate the effect of silencing NSD2 gene by RNA interference on proliferation, apoptosis and alteration Akt /mTOR signaling pathway in diffuse large B cell lymphoma OCI-Ly3 cells.The shRNA targeting was transfected into cells lentivirus infection. The mRNA protein were detected real time Q-PCR Western blot, respectively. proliferation CCK-8 measured flow cytometry. expressions BCL-2, BAX, caspase-3, Akt, p-Akt, p-mTOR, p-P70S6K, H3K36me2 blot.After transfecting NSD2-shRNA for 72 h,...
Abstract Lung adenocarcinoma (ADC) is a heterogeneous group of tumors associated with dramatically different survival rates, even when detected at an early stage. The overarching goal our research to identify the cellular and molecular predictors indolent aggressive behavior lung ADCs. In work presented here, we hypothesized that mass cytometry, single cell proteomic approach, would allow discovery determinants ADC behavior. To test this hypothesis, prepared cytometry panel 34 labeled...
s of Oral Proceedings: 2006 Joint Annual Meeting the AANS/CNS Cerebrovascular Section and American Society Interventional & Therapeutic Neuroradiology Caribe Royale Orlando—Orlando, Florida February 17–20, 2006: Anatomy:
Abstract Insights into tumor mutational burden of the airway epithelium may play important role in stratifying individuals at different levels risk for lung cancer. Comparison genetic profiles normal epithelial cells to mutations can yield valuable information regarding shared as well presence neoantigens. We hypothesized that cytologically bronchial patients with cancer and those high harbor driver be identified by deep targeted sequencing selected genes implicated whole exome sequencing....