A5100416767- Cancer-related molecular mechanisms research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer-related gene regulation
- Intracerebral and Subarachnoid Hemorrhage Research
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Medicinal Plants and Bioactive Compounds
- Plant-based Medicinal Research
- FinTech, Crowdfunding, Digital Finance
- Garlic and Onion Studies
- Food Chemistry and Fat Analysis
- S100 Proteins and Annexins
- Traumatic Brain Injury Research
- Sperm and Testicular Function
- Cancer, Hypoxia, and Metabolism
- Neonatal and fetal brain pathology
- BIM and Construction Integration
- Advancements in Transdermal Drug Delivery
- Corporate Social Responsibility Reporting
- Reproductive System and Pregnancy
- High Altitude and Hypoxia
- Evaluation and Optimization Models
- Gout, Hyperuricemia, Uric Acid
- Circular RNAs in diseases
- Curcumin's Biomedical Applications
Central South University
2018-2024
Xiangya Hospital Central South University
2018-2024
Zhejiang Gongshang University
2024
Henan University of Economic and Law
2021
China Pharmaceutical University
2018
State Key Laboratory of Natural Medicine
2018
Zhengzhou University
2018
Peking University First Hospital
2017
Peking University
2017
Beijing Chest Hospital
2017
Topical administration of anticancer drugs provides a potential chemotherapeutic modality with high patient compliance for cutaneous melanoma. However, the drug delivery efficiency is highly limited by physiological barriers from skin to tumor, which cannot acquire desired therapeutic efficacy. Herein, we propose paintable oligopeptide hydrogel containing paclitaxel (PTX)-encapsulated cell-penetrating-peptide (CPP)-modified transfersomes (PTX-CTs) enhance transdermal PTX topical melanoma...
Abstract Background The oral bioavailability and blood–brain barrier permeability of many herbal products are too low to explain the significant efficacy fully. Gut microbiota liver can metabolize ingredients more absorbable forms. current study aims evaluate ability a novel biotransformation-integrated network pharmacology strategy discover therapeutic mechanisms low-bioavailability in neurological diseases. Methods A on Astragaloside IV (ASIV) treating intracerebral hemorrhage (ICH) was...
Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of safflower (Carthamus tinctorius L., [Asteraceae]) for traumatic brain injury (TBI) treatment.To explore therapeutic effects and underlying mechanisms HSYA on post-TBI neurogenesis axon regeneration.Male Sprague-Dawley rats were randomly assigned into Sham, controlled cortex impact (CCI), groups. Firstly, modified Neurologic Severity Score (mNSS), foot fault test, hematoxylin-eosin staining, Nissl's immunofluorescence Tau1...
Purpose: Many herbs can promote neurological recovery following traumatic brain injury (TBI). There must lie a shared mechanism behind the common effectiveness. We aimed to explore key therapeutic targets for TBI based on effectiveness of medicinal plants. Material and methods: The TBI-effective were retrieved from literature as imputes network pharmacology. Then, active ingredients in at least two screened out components. hub all compounds identified through Cytohubba. Next, AutoDock vina...
Traditional Chinese medicine (TCM) exerts integrative effects on complex diseases owing to the characteristics of multiple components with targets. However, syndrome-based system diagnosis and treatment in TCM can easily lead bias because varying medication preferences among physicians, which has been a major challenge global acceptance application TCM. Therefore, standardized prescription needs be explored promote its clinical application. In this study, we first developed gradient weighted...
Background: Formononetin (FMN) is an isoflavone that produces arterial vasodilation. However, the underlying molecular mechanisms are unclear. Purpose: The purpose of this study was to explore vasorelaxant effect and potential mechanism FMN in vascular endothelium isolated rat aorta. Methods: thoracic aortas Sprague Dawley rats were test reactivity presence with or without inhibitors. Bioinformatics analyses, including a Analysis Tool for Molecular Mechanism Traditional Chinese Medicine...
Abstract Von Hippel‐Lindau ( VHL ) disease is a rare autosomal dominant cancer syndrome caused by alterations of gene. Patients are predisposed to develop pheochromocytomas and solid or cystic tumors the central nervous system, kidney, pancreas, retina. Remarkable phenotypic heterogeneity exits in organ involvement tumor onset age between within families. However, no reliable markers have been found predict age‐related risks patients. A large Chinese cohort composed 300 patients 92 healthy...
Traumatic brain injury (TBI) is a complex and serious disease as its multifaceted pathophysiological mechanisms remain vague. Molecular changes of hippocampal cortical dysfunction in the process TBI are poorly understood especially their chronic effects on metabolic profiles. Here, we utilize metabolomics based liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) bioinformatics method to assess perturbation metabolism rat hippocampus cortex day 7. The results revealed...
The deep integration of digital technology and finance is driving a rapid transformation financial services in China. Inclusive Finance, different from traditional finance, how to play the role “inclusive” on environmental decision-making promote national protection work? There little literature inquire Finance at micro level. This paper discusses impact inclusive enterprise investment its conduction mechanism. study found that could drive investment. In particular, usage depth has...
<title>Abstract</title> Curcumin (CUR) is found to exhibit a broad spectrum of potentially beneficial biological activities, which make it suitable as nutraceutical ingredient in functional foods and supplements. But its application for this purpose often limited by low water-solubility, chemical stability, bioavailability. In study, acid-treated soybean protein isolate (SPI) chitosan quaternary ammonium salt (CQAS) were used assemble colloidal carriers CUR form isolate-curcumin-chitosan...
Infertility affects approximately 15% of couples around the world, and male factors are accounted for 40-50%. Oligoasthenozoospermia is most common reason infertility. Unfortunately, effective drug therapy still lacking except assisted reproductive technology (ART). Previous researchers found that Wuzi Ershen decoction (WZESD) can increase sperm count, enhance vitality, improve semen quality. However, pharmacological mechanisms remain unclear.In this study, we screened compounds predicted...
Abstract Background Bi Zhong Xiao decoction (BZXD), a traditional Chinese herbal formula, has been used clinically for many years to treat rheumatoid arthritis (RA). Both clinical and experimental studies have revealed that BZXD is effective in treating RA, but the mechanism remains unclear. In this study, we aimed explore of efficacy through transcriptomic analysis lncRNA mRNA. Methods The combination method ultra-high performance liquid chromatography-mass spectrometry/mass spectrometry...
Now the real estate market is facing challenges in purchase of policy tsunami and development costs.As land prices have risen sharply, it urgent for enterprises such a harsh situation to survive develop.Most research results show that design stage largest most effective cost plasticity project.Therefore, great significance analyze control measures provide theoretical guidance enterprises.Against background today's industry, through analysis costs, this paper mainly discusses how use value...
ABSTRACT Han Chinese is the most populated ethnic group across globe with a comprehensive substructure that resembles its cultural diversification. Studies have constructed genetic polymorphism spectrum of Chinese, whereas high-resolution investigations are still missing to unveil fine-scale and trace imprints for demographic history. Here we construct haplotype network consisted 111,000 genome-wide genotyped individuals from direct-to-consumer testing over 1.3 billion identity-by-descent...
Ethnopharmacological relevance: The traditional Chinese herbal formula Xuefu Zhuyu decoction (XFZYD) is a classic in the category of invigorating blood circulation and resolving stasis. It has been proven to improve neurological ethological prognosis traumatic brain injury. XFZYD promotes synaptic axonal regeneration after injury, which functionally modulated by N6-methyladenosine (m6A) modification RNA. However, epigenetic effects on m6A remain unknown. Aim study: To explore how protected...