A5090449211- Neuroscience and Neural Engineering
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Neonatal Respiratory Health Research
- MicroRNA in disease regulation
- Bone and Joint Diseases
- Chronic Kidney Disease and Diabetes
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Inflammasome and immune disorders
- Bone health and treatments
- Ferroptosis and cancer prognosis
- Respiratory Support and Mechanisms
- Pulmonary Hypertension Research and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Monoclonal and Polyclonal Antibodies Research
First Affiliated Hospital of Jinan University
2022-2024
Jinan University
2018-2024
Shandong University of Traditional Chinese Medicine
2023
Activation of NF-κB-signalling is key in the pathogenesis chronic kidney diseases (CKD). However, a certain level NF-κB activity necessary to enable tissue repair.
Budding uninhibited by benzimidazole 1 (BUB1) is a highly conserved serine/threonine kinase, showing prominent importance for proper function during mitosis. However, little known about
Inflammation or dysbacteriosis-derived lipopolysaccharides (LPS) adversely influence the embryonic development of respiratory system. However, precise pathological mechanisms still remain to be elucidated. In this study, we demonstrated that LPS exposure caused lung maldevelopment in chick embryos, including higher embryo mortality, increased thickness alveolar gas exchange zone, and accumulation PAS+ immature pulmonary cells, accompanied with reduced expression epithelial cell markers...
Wiskott-Aldrich syndrome protein family member 2 (WASF2) has been shown to play an important role in many types of cancer. Therefore, it is worthwhile further study expression profile WASF2 human cancer, which provides new molecular clues about the pathogenesis ovarian cancer.We used a series bioinformatics methods comprehensively analyze relationship between and prognosis, tumor microenvironment (TME), immune infiltration, mutational burden (TMB), microsatellite instability (MSI), tried...
Fragile X mental retardation protein (FMRP) is an mRNA-binding that regulates local translation. FMRP loss or dysfunction leads to aberrant neuronal and synaptic activities in fragile syndrome (FXS), which characterized by intellectual disability, sensory abnormalities, social communication problems. Studies of function FXS pathogenesis have primarily been conducted with Fmr1 (the gene encoding FMRP) knockout transgenic animals. Here we report vivo method for determining the cell-autonomous...
Background: Wiskott-Aldrich syndrome protein family member 2 (WASF2) has been shown to play an important role in many types of cancer. Therefore, it will be valuable further study expression profile WASF2 human cancer, which provides new molecular clues about the pathogenesis ovarian cancer.Methods: We used a series bioinformatics methods comprehensively analyze relationship between gene and prognosis, tumor microenvironment (TME), immune infiltration various cancers from existing public...
Background: Using glucocorticoids (GCs) for a long term is common cause of osteonecrosis the femoral head (ONFH). Selenium (Se) an important oligo-element and component antioxidant system. An anti-inflammatory effect Se was reported recently. However, in unclear. The current study investigated function acting via ROS-PI3K/AKT to regulate bone metabolism GCs-induced ONFH (GIONFH).Methods : In vitro, various experimental methods were used detect viability, apoptosis osteogenesis primary...
Fragile X mental retardation protein (FMRP) is an mRNA-binding that regulates local translation. FMRP loss or dysfunction leads to aberrant neuronal and synaptic activities in fragile syndrome (FXS), which characterized by intellectual disability, sensory abnormalities, social communication problems. Studies of function FXS pathogenesis have primarily been conducted with Fmr1 (the gene encoding FMRP) knockout transgenic animals. Here we report vivo method for determining the cell-autonomous...