A5072694930- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Hereditary Neurological Disorders
- Biochemical and Structural Characterization
- Gestational Diabetes Research and Management
- Acute Ischemic Stroke Management
- Birth, Development, and Health
- Stroke Rehabilitation and Recovery
- Pregnancy and preeclampsia studies
- Vitamin D Research Studies
- Chronic Kidney Disease and Diabetes
- CAR-T cell therapy research
- MicroRNA in disease regulation
- Respiratory viral infections research
- Vitamin C and Antioxidants Research
- Immunodeficiency and Autoimmune Disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Intergenerational Family Dynamics and Caregiving
- Ovarian function and disorders
- Cardiac Health and Mental Health
- Bariatric Surgery and Outcomes
- Cardiac Fibrosis and Remodeling
- Heavy Metal Exposure and Toxicity
- Heavy metals in environment
- GDF15 and Related Biomarkers
University Medical Centre Mannheim
2023-2025
Charité - Universitätsmedizin Berlin
2023-2025
Academy of Scientific Research and Technology
2025
Heidelberg University
2023-2024
University Hospital Heidelberg
2024
Bankstown Lidcombe Hospital
2019
National Institute for Biological Standards and Control
2008-2016
Potters Bar Community Hospital
2008-2014
Minghsin University of Science and Technology
2014
National Yang Ming Chiao Tung University
2003
Activation of NF-κB-signalling is key in the pathogenesis chronic kidney diseases (CKD). However, a certain level NF-κB activity necessary to enable tissue repair.
The increasing prevalence of obesity-related glomerulopathy (ORG) poses a significant threat to public health. Sodium-glucose cotransporter-2 (SGLT2) inhibitors effectively reduce body weight and total fat mass in individuals with obesity halt the progression ORG. However, underlying mechanisms their reno-protective effects ORG remain unclear. We established high-fat diet-induced model using C57BL/6J mice, which were divided into three groups: normal chow diet (NCD group), (HFD) mice treated...
Abstract Relatively elevated concentrations of arsenic, lead, and mercury are toxic to the kidneys. However, it is unknown whether kidney function influenced by these metals in general population without diseases known exposure metals. We did a retrospective analysis data collected from 58,864 outpatients Germany January 2014 October 2022 undergoing measurements mercury. Routine clinical laboratory parameters were entered into database if they analyzed same patient within +/- four weeks...
AbstractBackground: High-salt diets (HSD) are known to impact blood pressure and cardiovascular health, but their effects on glucose metabolism, liver function, gut microbiota remain poorly understood. This study investigates how long-term HSD affects these physiological processes evaluates the potential therapeutic of ACE inhibitors (ACEIs) angiotensin II receptor blockers (ARBs). Methods: Male Sprague-Dawley rats were fed a normal salt diet (0.3% NaCl), moderate (2% or high-salt (8% NaCl)...
Background: Chronic kidney disease (CKD) is a global health concern, with renal fibrosis being major pathological feature. Empagliflozin (Empa), Sodium-glucose co-transporter-2 (SGLT2) inhibitor, has shown promise in protecting the kidney. This study aimed to investigate effects of Empa on non-diabetic CKD model and elucidate underlying mechanisms. Methods: We established using 5/6 nephrectomy (5/6 Nx) rats divided them into three groups: placebo-treated sham surgery rats, Nx Empa-treated...
Botulinum toxins (BoNTs) are among the most toxic substances on earth, with serotype A toxin being substance known. They responsible for human botulism, a disease characterized by flaccid muscle paralysis that occurs naturally through food poisoning or colonization of gastrointestinal tract BoNT-producing clostridia. BoNT has been classified as category agent Centers Disease Control, and it is one six agents highest potential risk use bioweapons. Human human-like neutralizing antibodies thus...
Target values for 25-hydroxy vitamin D and 1,25(OH)
Botulinum neurotoxins (BoNTs) cause the life-threatening neurological illness botulism in humans and animals are divided into seven serotypes (BoNT/A-G), of which A, B, E, F disease humans. BoNTs classified as "category A" bioterrorism threat agents relevant context Biological Weapons Convention. An international proficiency test (PT) was conducted to evaluate detection, quantification discrimination capabilities 23 expert laboratories from health, food security areas. Here we describe three...
Abstract Context Gestational diabetes mellitus (GDM) is a common pregnancy complication, particularly in women undergoing assisted reproductive technology (ART). An association of GDM with vitamin D conceiving naturally has been described; however, studies have yielded heterogeneous results. Objective To analyze the between prepregnancy total and free incidence ART. Methods Post hoc analysis prospective study at Reproductive Genetic Hospital CITIC-Xiangya Changsha, China. Total were measured...
To explore whether maternal baseline systolic blood pressure (SBP) and diastolic (DBP) affect pregnancy outcomes particularly in normotensive women (SBP, 90-139 mm Hg; DBP, 60-89 Hg) hypertensive undergoing vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).
Background: Periostin is a matricellular protein. Elevated serum concentrations of periostin have been reported in patients with various cardiovascular diseases, including heart failure. Patients end-stage renal disease substantially increased risk for diseases. However, there lack clinical studies to clarify the prognostic significance systemic on all-cause mortality hemodialysis. Methods: 313 stable were recruited and followed five years concerning mortality. At baseline, we collected...
Botulinum neurotoxins (BoNTs) are considered to be the most toxic substances known on earth and responsible for human botulism, a life-threatening disease characterized by flaccid muscle paralysis that occurs naturally food-poisoning or colonization of gastrointestinal tract BoNT-producing clostridia. BoNTs have been classified as category A agent Centers Disease Control Prevention (CDC) listed among six agents with highest risk used bioweapons. Neutralizing antibodies required development...
Botulinum neurotoxins (BoNTs) are counted among the most toxic substances known and responsible for human botulism, a life-threatening disease characterized by flaccid muscle paralysis that occurs naturally food poisoning or colonization of gastrointestinal tract BoNT-producing clostridia. To date, 7 serologically distinct serotypes BoNT (serotype A-G) known. Due to high toxicity BoNTs Centers Disease Control Prevention (CDC) have classified as category A agent, including six biological...
Due to rare but major adverse reactions the AstraZeneca adenoviral ChAdOx1-S-nCoV-19 vaccine (ChAd), German health authorities recommended adults under 60 who received one dose of ChAd, receive a second BioNTech mRNA BNT162b2 (BNT) as booster. Studies in general population suggest an enhanced efficacy heterologous (ChAd-BNT) compared homologous (BNT-BNT) vaccination regimen. However, analysis patient populations with high risk severe COVID-19 due acquired immunodeficiency is still missing....
Abstract Background Botulinum neurotoxin A (BoNT/A), mainly represented by subtype A1, is the most toxic substance known. It causes naturally-occurring food poisoning, and among biological agents at highest risk of being weaponized. Several antibodies neutralizing BoNT/A targeting its heavy chain (BoNT/A-H) have been isolated in past. For first time however, an IgG (4LCA) recently hybridoma technology light (BoNT/A-L), was shown to inhibit endopeptidase activity protect vivo against BoNT/A....
Botulinum neurotoxins (BoNTs) cause botulism and are the deadliest naturally-occurring substances known to humans. BoNTs have been classified as one of category A agents by Centers for Disease Control Prevention, indicating their potential use bioweapons. To counter bio-threat cases, well-tolerated antibodies humans that neutralize relevant. In our previous work, we showed neutralizing macaque (Macaca fascicularis)-derived scFv-Fc (scFv-Fc ELC18) in vitro endopeptidase immunoassay ex vivo...
Background Pulmonary manifestations are the major cause of morbidity and mortality in patients with inborn errors immunity (IEI). New more sensitive diagnostic methods can potentially lead to earlier recognition treatment IEI lung disease improve outcome. The aim this study was compare multiple-breath washout (MBW) spirometry cystic fibrosis (CF) as well healthy controls (HC) evaluate sensitivity clearance index (LCI) assess IEI. Methods (n=114) were recruited from our paediatric adult...
Vitamin D is a fat-soluble steroid that influences cardiovascular health by affecting lipid metabolism. Since dyslipidemia key risk factor for disease (CVD), our study aimed to explore the relationship between vitamin levels and parameters, considering effects of age gender.
Background Vitamin D binding protein (DBP) might increase substantially after ovarian stimulation and hence could be associated with IVF/ICSI outcomes because it determines the fraction of free bioavailable 25(OH) vitamin D. In this study, we aim to determine whether DBP is E2 level outcomes. Design Post-hoc analysis a prospective observational cohort. Setting Single-center study. Participants 2569 women receiving embryo transfer. Intervention None. Main outcome measures The main were oocyte...
TPS5092 Background: Prostate cancer (CaP) is the most common in US men. Disseminated CaP invariably progresses to metastatic castrate-resistant prostate (mCRPC). Current treatment options for mCRPC usually lead therapeutic resistance, and novel therapies are urgently needed. PSMA a prostate-specific antigen over-expressed on mCRPC. Antibodies against have been used create T-cell engaging bispecific Abs (TCEs) chimeric receptor T cells, but all such approaches date induce frequent/severe...
Background: Preclinical animal studies and clinical indicate that both maternal as well paternal genetic alterations/gene defects might affect the phenotype of next-generation without transmissions affected gene. Currently, question whether same defect present in mother or father leads to a similar offspring remains insufficiently elucidated. Methods: In this head-to-head study, we crossbred female male mice with heterozygous endothelial eNOS knockout (eNOS+/−) wild-type (wt) mice,...
Sclerostin (SOST) is produced by osteocytes and known as a negative regulator of bone homeostasis. Parathyroid hormone (PTH) regulates calcium, phosphate well vitamin D metabolism, strong inhibitor SOST synthesis in vitro vivo. PTH has two methionine amino acids (positions 8 18) which can be oxidized. oxidized at Met18 (Met18(ox)-PTH) continues to bioactive, whereas Met8 (Met8(ox)-PTH) or (Met8, Met18(di-ox)-PTH) minor bioactivity. How non-oxidized (n-oxPTH) forms act on sclerostin unknown....