A5100708037- Tissue Engineering and Regenerative Medicine
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Electrospun Nanofibers in Biomedical Applications
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Advanced biosensing and bioanalysis techniques
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Lung Cancer Treatments and Mutations
- Mesenchymal stem cell research
- Cancer, Hypoxia, and Metabolism
- Sexual function and dysfunction studies
- Cancer, Lipids, and Metabolism
- Lung Cancer Research Studies
- Respiratory Support and Mechanisms
- Bladder and Urothelial Cancer Treatments
- Bioactive Natural Diterpenoids Research
- RNA modifications and cancer
- Genetics, Aging, and Longevity in Model Organisms
- HIV Research and Treatment
- Neuroscience and Music Perception
- Biosensors and Analytical Detection
Capital Medical University
2020-2024
Tianjin Nankai Hospital
2024
Shandong University
2016-2024
Stanford University
2024
Nankai University
2023-2024
Shanghai Public Health Clinical Center
2024
Jinan University
2017-2023
First Affiliated Hospital of Guangzhou Medical University
2018-2023
Guangzhou Medical University
2018-2023
Beijing Radiation Center
2015-2023
Alzheimer's disease (AD) is a progressive and irreversible brain degenerative disorder. Mild cognitive impairment (MCI) clinical precursor of AD. Although some treatments can delay its progression, no effective cures are available for Accurate early-stage diagnosis AD vital the prevention intervention progression. Hippocampus one first affected regions in To help diagnosis, shape volume hippocampus often measured using structural magnetic resonance imaging (MRI). However, these features...
PURPOSE To assess whether the integration of PD-1 inhibitor with total neoadjuvant therapy (iTNT) can lead to an improvement in complete responses (CRs) and favors a watch-and-wait (WW) strategy patients proficient mismatch repair or microsatellite stable (pMMR/MSS) locally advanced rectal cancer (LARC). PATIENTS AND METHODS We conducted prospective, multicenter, randomized, open-label, phase II trial using pick-the-winner design. Eligible clinical T3-4 and/or N+ adenocarcinoma were randomly...
Oridonin (Ori) is a natural tetracyclic diterpenoid active compound with excellent antitumor activity, but the mechanism of Ori on esophageal cancer cell, TE1, remains unclear. In this study, we examined levels intracellular iron, malondialdehyde, and reactive oxygen species after treatment, while interfering effects ferroptosis inhibitor, demonstrating that Ori's inhibition TE1 cell proliferation associated ferroptosis. To understand molecular Ori, performed UPLC–MS/MS metabolomics...
A novel single-cell analysis platform was fabricated using solid-state zinc-coadsorbed carbon quantum dot (ZnCQDs) nanocomposites as an electrochemiluminescence (ECL) probe for the detection of breast cancer cells and evaluation CD44 expression level. Solid-state ZnCQDs nanocomposite probes were constructed through attachment to gold nanoparticles then loading magnetic beads amplify ECL signal, exhibiting a remarkable 120-fold enhancement intensity. Hyaluronic acid (HA)-functionalized used...
Chemotherapy is the main treatment for bladder cancer, but drug resistance and side effects limit its application therapeutic effect. Herein, we constructed doxorubicin (DOX)/COOH-mesoporous silica nanoparticle/polyethylenimine (PEI)/nucleic acid chimeras (DOX/MSN/Chimeras) to reduce toxicity of chemotherapy drugs cancer cells. Transmission electron microscopy showed that PEI was coated on DOX/MSN/BSA nanoparticles with a diameter about 150 nm. DOX/MSN/PEI could control DOX release over 48...
Necroptosis is a programmed form of necrosis and compounds inducing necroptosis may contribute to cancer treatment. 20(S)-ginsenoside Rg3 natural compound extracted from ginseng, which exhibited broad-spectrum antitumor activity. In the present study, potential role in prostate cells was evaluated. inhibited proliferation upregulated expression necroptotic proteins such as receptor-interacting serine/threonine-protein kinase 1 (RIPK1), RIPK3, their downstream mixed lineage domain-like...
Mesenchymal stem cells (MSCs) can be polarized into two distinct populations, MSC1 and MSC2, by activation of different Toll-like receptors (TLRs). TLR4-primed expressed proinflammatory factors, whereas TLR3-primed MSC2 suppressive factors. However, little is known about the function TLRs on B lymphocyte-related immune modulation. In this study, we investigated expression cell activating factor (BAFF), a member tumor necrosis ligand superfamily with notable stimulating activity cells, in...
BackgroundHepatocellular carcinoma (HCC) is prevalent worldwide and early diagnosis of HCC critical for effective treatment optimal prognosis.MethodsSerum was screened first by immunoproteomic analysis HCC-related tumor associated antigens (TAAs). Selected TAAs were clinically evaluated retrospectively in patients with HCC, liver cirrhosis, chronic hepatitis healthy controls. Levels autoantibody to the selected measured protein microarrays containing candidate TAAs. Analyses done using...
To investigate the potential antitumor effects of ginsenoside Rg3 in prostate cancer cells, androgen‑insensitive cell line PC3 was cultured and incubated with vitro. Cell number counts, proliferation assays senescence‑associated β‑galactosidase (SA‑β‑gal) staining were performed to evaluate proliferation. The results demonstrated that led arrest; decreased cells increased positive SA‑β‑gal rate cells. cycle analysis by flow cytometry revealed interfered G1/S transition mechanism involved...
Abstract Zinc fingers and homeoboxes 2 (ZHX2) was found as a novel VHL substrate target, acted an oncogenic driver in ccRCC. However, the detailed mechanism of ZHX2 ccRCC development remains elusive, no research has focused on studying drug resistance yet. A tissue microarray with 358 samples used to determine expression patients. VHL-deficient cell line 786-O VHL-normal CAKI-1 for lineage reprogramming by transfecting lentivirus. The vitro vivo experiments were performed these new lines...
Papillary thyroidal carcinoma (PTC) is a common endocrine cancer that plagues people across the world. The potential roles of long non-coding RNAs (lncRNAs) in PTC have gained increasing attention. In this study, we aimed to explore whether lncRNA ROR affects progression PTC, with involvement tescalcin (TESC)/aldehyde dehydrogenase isoform 1A1 (ALDH1A1)/βIII-tubulin (TUBB3)/tensin homolog (PTEN) axis. tumor and adjacent tissues were obtained, followed by measurement TESC, ALDH1A1, TUBB3...
Human regulatory T cells (Treg) suppress other immune cells. Their dysfunction contributes to the pathophysiology of autoimmune diseases, including type 1 diabetes (T1D). Infusion Tregs is being clinically evaluated as a novel way prevent or treat T1D. Genetic modification Tregs, most notably through introduction chimeric antigen receptor (CAR) targeting pancreatic islets, may improve their efficacy. We CAR human monocytes, β cell line and islet in vitro . Targeting HLA-A2-CAR (A2-CAR) bulk...
Background Erythrocyte dysfunction is a characteristic of diabetes mellitus (DM). However, erythrocyte-associated biomarkers do not adequately explain the high prevalence DM. Here, we describe red blood cell distribution width to albumin ratio (RAR) as novel inflammatory biomarker for evaluating an association with DM and prognosis all-cause mortality. Methods Data analyzed in this study were extracted from National Health Nutrition Examination Survey (NHANES) 1999−2020. A total 40,558...
Bladder acellular matrix graft-alginate dialdehyde-gelatin hydrogel-silk mesh (BAMG-HS) encapsulated with adipose-derived stem cells (ASCs) was evaluated in a rat model of augmentation cystoplasty, including BAMG-HS-ASCs (n = 18, subgroup n 6 for 2, 4, and 12 weeks), BAMG-HS weeks) cystotomy control groups. Equipped good cytocompatibility superior mechanical properties (elastic modulus: 5.33 ± 0.96 MPa, maximum load: 28.90 0.69 N), acted trilayer "sandwich" scaffold minimal interference...
Cancer cell chemoresistance is the primary reason behind cancer treatment failure. Previous reports suggest that circular RNA (circRNA) hsa_circ_0074027 (HC0074027) a crucial modulator of non-small lung (NSCLC) disease progression. Herein, we delineated underlying mechanism HC0074027-regulated in NSCLC. We employed quantitative real-time polymerase chain reaction (qRT-PCR) or Elisa detection HC0074027, micoRNA-379-5p (miR-379-5p), and insuline-like growth factor I (IGF1) expressions. Cell...
Small-cell lung cancer (SCLC) is one of the most aggressive cancers with mechanisms far from understood.We proposed to identify valuable prognostic signature for SCLC prognosis prediction.microRNA (miRNA) expression profiles 42 patients were acquired Gene Expression Omnibus. miRNAs that significantly associated overall survival (OS-relevant) identified through univariate Cox regression analysis followed by random forest identification more reliable miRNA signature.Eleven OS-relevant...