A5087215878- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- CAR-T cell therapy research
- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Lysosomal Storage Disorders Research
- Cancer Research and Treatments
Nanchang University
2025
Chinese PLA General Hospital
2024
Air Force Medical University
2009
Chemotherapy is the main treatment for bladder cancer, but drug resistance and side effects limit its application therapeutic effect. Herein, we constructed doxorubicin (DOX)/COOH-mesoporous silica nanoparticle/polyethylenimine (PEI)/nucleic acid chimeras (DOX/MSN/Chimeras) to reduce toxicity of chemotherapy drugs cancer cells. Transmission electron microscopy showed that PEI was coated on DOX/MSN/BSA nanoparticles with a diameter about 150 nm. DOX/MSN/PEI could control DOX release over 48...
Abstract Aim To investigate the role of O‐GlcNAc transferase (OGT)‐mediated protein O‐GlcNAcylation in podocyte injury during progression diabetic kidney disease (DKD). Materials and Methods Proteomic O‐glycoproteomic analyses were conducted on high glucose (HG)‐stimulated podocytes with OGT knockdown. Differentially expressed proteins O‐GlcNAcylated peptides/proteins identified, functional enrichment (GO, KEGG, COG/KOG) motif analysis (motif‐x) performed using bioinformatics analysis....
Combination therapy has become the most important treatment for advanced non-small cell lung cancer (NSCLC), which can significantly improve prognosis of patients. However, poor targeting and adverse reactions limited its clinical application. Here, we constructed an AS1411 aptamer-programmed death ligand-1 (PD-L1) siRNA chimera/polyethylenimine/glutamine/β-cyclodextrin/doxorubicin (Chimera/ PEI/Gln/β-CD/DOX) nanoparticle combination (chemotherapy combined with immunotherapy). Scanning...
Background: Overexpression of melanoma cell adhesion molecule (MCAM or CD146), a novel member the immunoglobulin gene superfamily, promotes invasion, metastasis, growth and survival malignant cells. Materials methods: Here, we used human U6 promoter‐driven DNA template approach to induce short hairpin RNA (shRNA)‐triggered interference block CD146 expression in high‐metastatic adenoid cystic carcinoma (ACC) line ACC‐M. reverse transcription‐polymerase chain reaction, Western blot,...