A5101297771- Cell death mechanisms and regulation
- Trace Elements in Health
- Inhalation and Respiratory Drug Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mitochondrial Function and Pathology
- Inflammasome and immune disorders
- Platelet Disorders and Treatments
- Pancreatitis Pathology and Treatment
- Blood properties and coagulation
- Electrospun Nanofibers in Biomedical Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Integrated Circuits and Semiconductor Failure Analysis
- Bariatric Surgery and Outcomes
- 3D Printing in Biomedical Research
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenetic and Muscular Disorders Research
- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Nuclear Structure and Function
- Cancer Risks and Factors
- VLSI and Analog Circuit Testing
- Occupational exposure and asthma
- Tissue Engineering and Regenerative Medicine
- Occupational and environmental lung diseases
Ningbo University
2024
Ningbo First Hospital
2022-2024
Zhejiang University
2024
Nanjing University of Chinese Medicine
2024
First Affiliated Hospital of Jinan University
2022-2023
State Key Laboratory of Respiratory Disease
2018-2022
Second Affiliated Hospital of Guangzhou Medical University
2018-2022
Guangzhou Medical University
2018-2022
University of Electronic Science and Technology of China
2017
Peripheral nerve injuries (PNIs) can cause neuropathies and significantly affect the patient's quality of life. Autograft transplantation is gold standard for conventional treatment; however, its application limited by unavailability, size mismatch, local tissue adhesion. Tissue engineering, such as guidance conduits, an alternative promising strategy to guide regeneration peripheral repair; only a few conduits could reach high repair efficiency autografts. The healing process PNI frequently...
Abstract Necroptosis of intestinal epithelial cells has been indicated to play an important role in the pathogenesis inflammatory bowel disease (IBD). The identification dysregulated proteins that can regulate necroptosis dextran sulfate sodium (DSS)-induced colitis is key rational design therapeutic strategies for colitis. Through tandem mass tag (TMT)-based quantitative proteomics, HtrA2 was found be downregulated colon DSS-treated mice. UCF-101, a specific serine protease inhibitor HtrA2,...
Background & AimsIncreased vascular permeability (VP) has been indicated to play an important role in the pathogenesis of inflammatory bowel disease (IBD). However, pathological causes increased intestinal VP IBD remain largely unknown.MethodFibrinogen level was measured dextran sulphate sodium (DSS)-induced colitis and patients with ulcerative colitis. Gly-Pro-Arg-Pro acetate (GPRP), Fg inhibitor, used detect effect inhibition on DSS-induced colitis, as by tissue damage, cytokine release...
Abstract Alveolar epithelial injury is one of the important pathological changes in idiopathic pulmonary interstitial fibrosis (IPF), but regulatory mechanism remains unclear. Here, we reported that alveolar type-II cells (AT II) play roles process fibrosis. Through iTRAQ (isobaric tagging for relative and absolute quantification) quantitative proteomics, TSSK4 was identified to be upregulated bleomycin-induced fibrotic mice model, which further confirmed clinical IPF patients’ tissue...
Abstract A dramatic increase in the incidence of inflammatory bowel disease (IBD) has been observed past two decades, mainly developed countries and also developing regions. Necroptosis found to play an important role pathogenesis IBD, suggesting its inhibitors are promising clinic. However, clinical drugs targeting necroptosis seriously lacking. Through screening a compound library that contains 611 inhibitors, pan-RAF inhibitor LY3009120 was be as inhibitor. inhibited vitro, inhibition...
Peripheral nerve injuries cause an absence or destruction of nerves. Decellularized nerves, acting as a replacement for autografts, have been investigated in the promotion repair and regeneration, always being incorporated with stem cells growth factors. However, such strategy is limited by size availability. The potential application heterotopic transplantation other decellularized tissues needs to be further explored. In this study, rat kidney (dK) was selected compared peripheral (dN),...
Single umbilical artery (SUA) may be associated with adverse pregnancy outcomes, such as fetal death, emergency cesarean section, premature delivery, small-for-gestational-age infants, and admission to neonatal intensive care unit, some SUAs are transformed from originally double arteries (UA). The pulsatility index (PI) can reflect the resistance of UA, clinicians attach importance high PI but easily overlook low levels it. We reported one case a pregnant woman who underwent single UA...
Bariatric and metabolic surgery (BMS) is an effective treatment for obesity its complications, but effect on pregnancy outcomes inconclusive. The present study aimed to investigate women's status as well the impact of intervals after BMS.The menstrual cycle fertility women who underwent BMS in our centre between July 2010 January 2021 were retrospectively analyzed followed up until one-year post-delivery. observed, including changes weight, interval, weight health newborn (premature birth,...
The rapid development of integrated circuit design and manufacturing technology has brought great challenges to the testing diagnosis, analog fault diagnosis is still difficulty focus diagnosis. Due continuous parametric values unpleasant nonlinearity increasing in circuit, technologies less advanced than that digital circuits. In this paper, on basis existing research in-depth interpretation method based complex model, two order Thomas filter as an example verify theory, been verified...
Background: Wiskott-Aldrich syndrome protein family member 2 (WASF2) has been shown to play an important role in many types of cancer. Therefore, it will be valuable further study expression profile WASF2 human cancer, which provides new molecular clues about the pathogenesis ovarian cancer.Methods: We used a series bioinformatics methods comprehensively analyze relationship between gene and prognosis, tumor microenvironment (TME), immune infiltration various cancers from existing public...
Abstract Necroptosis of intestinal epithelial cells has been indicated to play an important role in the pathogenesis inflammatory bowel disease (IBD). The identification dysregulated proteins that can regulate necroptosis dextran sulfate sodium (DSS)-induced colitis is key rational design therapeutic strategies for colitis. Through Tandem Mass Tag (TMT)-based quantitative proteomics, HtrA2 was found be downregulated colon DSS-treated mice. UCF-101, a specific serine protease inhibitor HtrA2,...
Abstract Pseudomonas aeruginosa induced acute lung injury is such a serious risk to public health throughout the world, but pathological regulation remains unclear. Here, we reported that P. ae mediated epithelial necroptosis leads subsequent immune responses and plays an important role in pulmonary process. Pharmacological genomic ablation of signaling ameliorate inflammation. Our results further proved NLRP3 inflammasome involve ALI. Mechanism investigation revealed cross-talking patterns...