A5103200060- Asthma and respiratory diseases
- Peptidase Inhibition and Analysis
- Occupational exposure and asthma
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Protein Degradation and Inhibitors
- Inflammatory Biomarkers in Disease Prognosis
- IL-33, ST2, and ILC Pathways
- Pneumocystis jirovecii pneumonia detection and treatment
- Extracellular vesicles in disease
- Histone Deacetylase Inhibitors Research
- Pediatric health and respiratory diseases
- Indoor Air Quality and Microbial Exposure
- Immune cells in cancer
- Mast cells and histamine
- Cancer and biochemical research
- Cardiomyopathy and Myosin Studies
- Cell death mechanisms and regulation
- Alcohol Consumption and Health Effects
- Psoriasis: Treatment and Pathogenesis
- Diet, Metabolism, and Disease
- Bacteriophages and microbial interactions
- Islamic Finance and Communication
- Allergic Rhinitis and Sensitization
- Eosinophilic Disorders and Syndromes
- Fibromyalgia and Chronic Fatigue Syndrome Research
Southern University of Science and Technology
2021-2025
University of Electronic Science and Technology of China
2020-2024
Sichuan Cancer Hospital
2020-2024
Chengdu Women's and Children's Central Hospital
2021-2024
Zhuhai People's Hospital
2022
Jinan University
2021-2022
Guangzhou Medical University
2020-2022
State Key Laboratory of Respiratory Disease
2020-2021
Second Affiliated Hospital of Guangzhou Medical University
2020-2021
Tianjin Hospital
2021
Chronic obstructive pulmonary disease (COPD) is a progressive chronic lung characterized by airway inflammation and emphysema. Macrophage polarization plays an important role in COPD pathogenesis secreting inflammatory mediators. Bromodomain-containing protein 4 (BRD4), epigenetic reader that specifically binds to histones, crucial diseases regulating macrophage polarization. Herein, we attempted examine the hypothesis modulating alveolar via BRD4 inhibitors might has potential for...
Accumulating evidence indicated the crucial role for interleukin 6 (IL-6) signaling in development of allergic asthma. Yet, IL-6 toluene diisocyanate (TDI)-induced mixed granulocytic airway inflammation still remains unclear. Thus, aims this study were to dissect and evaluate effect tocilizumab on TDI-induced steroid-resistant asthma.TDI-induced asthma model was prepared asthmatic mice respectively given monoclonal antibody, IL-6R antibody (tocilizumab, 5 mg/kg, i.p. after each challenge)...
Abstract Background Childhood‐onset systemic lupus erythematosus (cSLE) is a chronic autoimmune disease that often more severe than adult‐onset SLE and challenging to diagnose due its variable presentation lack of specific diagnostic tests. Objectives This study aimed identify potential biomarkers for cSLE by analyzing differentially expressed genes (DEGs) using machine learning algorithms. Methods In this study, we utilized the Gene Expression Omnibus database investigate DEGs between...
Studies have indicated that interleukin 23 (IL-23) plays an important role in many inflammatory- and autoimmune-related diseases. However, there is little knowledge about IL-23 lumbar disc herniation (LDH). Thus, this study, we aimed to find out whether expressed intervertebral discs (IVDs) what roles it may play.Human IVD tissues were collected from 29 LDH patients 8 vertebral fracture (normal control, NC group). According the integrity of annulus fibrosus, divided into two groups: R group...
Accumulating evidence has suggested that toll-like receptor 4 (TLR4) is critically involved in the pathogenesis of asthma. The aim this study was to investigate role TLR4 toluene diisocyanate (TDI)-induced allergic airway inflammation.TLR4-/- and wild-type (WT) C57BL/10J mice were sensitized challenged with TDI generate a TDI-induced asthma model. B-cell lymphoma 2 (Bcl-2) inhibitors, ABT-199 (4 mg/kg) ABT-737 mg/kg), intranasally given TDI-exposed TLR4-/- after each challenge.TDI exposure...
Abstract Background Chronic obstructive pulmonary disease (COPD) is a progressive chronic lung characterized by airway inflammation and emphysema. Macrophage polarization plays an important role in COPD pathogenesis secreting inflammatory mediators. Bromodomain-containing protein 4 (BRD4), epigenetic reader that specifically binds to histones, crucial diseases regulating macrophage polarization. Herein, we attempted examine the hypothesis modulating alveolar via BRD4 inhibitors might has...
<title>Abstract</title> Background While the PRP (platelet-rich plasma) method was most widely used in tumor-educated platelets (TEPs) research, there were still peripheral blood unextracted which are whose histology and function currently alien. Objectives To prove existed, to explore correlation of with lung cancer progression. Methods A second centrifugation step establish a modified approach, compared based on PRR (platelet recovery rate). Sequencing analysis platelets. Results The...
Interleukin (IL)-17A plays a critical role in the pathogenesis of allergic airway inflammation. Yet, exact roles IL-17A asthma are still controversial. Thus, aim this study was to dissect toluene diisocyanate (TDI)-induced mixed granulocytic and assess effects neutralizing antibody different effector phases on TDI-induced asthma.IL-17A functions inflammation were evaluated using mice deficient (Il17a-/-) or monoclonal (IL-17A mab, intraperitoneally, 50 μg per mouse, 100 mouse). Moreover,...
Objective To assess regional left ventricular systolic function in patients with hypertrophic cardiomyopathy (HCM) using real-time three-dimensional echocardiography (RT-3DE).Methods Twenty-five HCM which was asymmetric septal hypertrophy,and twenty healthy subjects were enrolled the study.The apical four-chamber view of acquired by RT-3DE.The volume-time curves analyzed quantitatively Tomtec 4D LV-Analysis 3.0,and end-diastolic volume and end-systolic (rEDV,rESV),the time to minimum...
Background and Objective: Idiopathic pulmonary fibrosis is a chronic progressive disease associated with substantial morbidity mortality despite advances in medical therapy. Increasing evidence suggests that peroxisome proliferator-activated receptors (PPARs) play important roles the fibrosis-related diseases their agonists may become effective therapeutic targets. Pemafibrate selective PPARα agonist, but efficacy against mechanisms involved have not been systematically evaluated. Thus, aims...
Background: TDI-induced asthma is characterized by neutrophil-dominated airway inflammation and often associated with poor responsiveness to steroid treatment. Both PI3Kδ PI3Kγ have been demonstrated play important proinflammatory roles in ovalbumin-induced asthma. We’ve already reported that blocking pan PI3K effectively attenuated allergic inflammation. Yet the specific functions of are still unclear. Methods: Male BALB/c mice were first dermally sensitized then challenged TDI generate an...