A5015476192- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Adenosine and Purinergic Signaling
- Atrial Fibrillation Management and Outcomes
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Nitric Oxide and Endothelin Effects
- Influenza Virus Research Studies
- Wireless Sensor Networks and IoT
- RNA modifications and cancer
- E-commerce and Technology Innovations
- Asthma and respiratory diseases
- Cancer-related gene regulation
- COVID-19 epidemiological studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Educational Reforms and Innovations
- Cardiovascular Function and Risk Factors
- Platelet Disorders and Treatments
- Wireless Communication Networks Research
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Pediatric health and respiratory diseases
- Inflammatory mediators and NSAID effects
- COVID-19 and Mental Health
Jinan University
2016-2025
Southern University of Science and Technology
2020-2025
Shandong University
2023-2025
Lund University
2005-2024
Skåne University Hospital
2015-2024
Xi'an Aeronautical University
2021-2024
ShenZhen People’s Hospital
2020-2023
Tianjin Medical University Cancer Institute and Hospital
2023
PLA Information Engineering University
2023
Affiliated Zhongshan Hospital of Dalian University
2022
P2 receptors mediate the actions of extracellular nucleotides ATP, ADP, UTP, and UDP, regulating several physiologic responses including cardiac function, vascular tone, smooth muscle cell (SMC) proliferation, platelet aggregation, release endothelial factors. receptor characterization has been hampered by lack selective antagonists. The aim current study was to investigate mRNA protein expression P2X P2Y in human SMC cells (EC). Smooth were obtained from mammary artery EC umbilical vein....
ADP plays an important role in platelet aggregation by activating P2Y12 receptors. We assessed the hypothesis that receptors are expressed vascular smooth muscle cells (VSMC).P2Y12 receptor mRNA was found to have a high expression among P2 human VSMC, significantly higher than other 2 (P2Y1 and P2Y13, real-time polymerase chain reaction). Western blots gave band of 50 kD, similar platelets. To unmask receptor-mediated vasoconstriction simulating vivo situation, vessels were precontracted...
Abstract Background Extracellular nucleotides (ATP, ADP, UTP and UDP) exert a wide range of biological effects in blood cells mediated by multiple ionotropic P2X receptors G protein-coupled P2Y receptors. Although pharmacological experiments have suggested the presence several P2 receptor subtypes on monocytes lymphocytes, some results are contradictory. Few physiological functions been firmly established to specific subtype, partly because lack truly selective agonists antagonists. This...
Identification of potential novel targets for reversing resistance to Epidermal Growth Factor Receptor (EGFR)-tyrosine kinase inhibitors (EGFR-TKIs) holds great promise the treatment relapsed lung adenocarcinoma (LUAD). In present study, we aim investigate role methyltransferase-like 7B (METTL7B) in inducing EGFR-TKIs LUAD and whether it could be a therapeutic target resistance.METTL7B-overexpressed cell lines, gefitinib osimertinib-resistant Cell-Derived tumor Xenograft (CDX)...
Abstract To improve the sluggish kinetics of hydrogen evolution reaction (HER), a key component in water‐splitting applications, there is an urgent desire to develop efficient, cost‐effective, and stable electrocatalysts. Strain engineering proving efficient strategy for increasing catalytic activity This work presents development Ru‐Au bimetallic aerogels by simple one‐step situ reduction‐gelation approach, which exhibits strain effects electron transfer create remarkable HER stability...
Red blood cells may regulate tissue circulation and O2 delivery by releasing the vasodilator ATP in response to hypoxia. When released extracellularly, is rapidly degraded ADP ectonucleotidases. In this study, we show that acting on P2Y13 receptors red serves as a negative feedback pathway for inhibition of release. mRNA receptor was highly expressed human reticulocytes. The stable analogue 2-MeSADP decreased release from cAMP. P2Y12 antagonist AR-C67085 (30 micromol/L), but not P2Y1 blocker...
Abstract The electrocatalytic oxidation of glucose plays a vital role in biomass conversion, renewable energy, and biosensors, but significant challenges remain to achieve high selectivity activity simultaneously. In this study, we present novel approach for achieving complete electrooxidation utilizing Cu‐based metal‐hydroxide‐organic framework (Cu‐MHOF) featuring coordinatively unsaturated Cu active sites. contrast traditional Cu(OH) 2 catalysts, the Cu‐MHOF exhibits remarkable 40‐fold...
Object. The aim of this study was to assess the efficacy and safety radiosurgery for treatment dural arteriovenous fistulas (DAVFs) located in region transverse—sigmoid sinus. Methods. A series 20 patients with DAVFs sinus, who were treated gamma knife surgery between June 1995 2000, evaluated. According Cognard classification, DAVF Type I four patients, IIa seven, IIb two, combined IIa+b seven. Nine had previously been and/or embolization, whereas 11 underwent alone. Radiosurgery performed...
The aim of this study was to examine a possible role for extracellular pyrimidines as inotropic factors the heart. First, nucleotide plasma levels were measured evaluate whether UTP is released in patients with coronary heart disease. Then, effects examined isolated mouse cardiomyocytes. Finally, expression pyrimidine-selective receptors (a subgroup P2 receptors) studied human and heart, using real time polymerase chain reaction, Western blot, immunohistochemistry. Venous increased (57%)...
Spin-state modulation in ZnCo 2 O 4 spinel oxides through calcination-induced lattice distortion enhances metal ion sensing performance, with a direct correlation between the Co 3+ spin state and electrochemical behavior.
After the coronavirus disease 2019 (COVID-19) pandemic, no studies on bacterial and atypical pathogens were conducted in primary care. We aimed to describe etiological composition of acute respiratory tract infections (ARTIs) presenting care with limited resources after pandemic. 1958 adult patients ARTIs from 17 clinics recruited prospectively January 2024 March 2024. 62 throat swab samples tested using polymerase chain reaction (PCR) targeted next-generation sequencing (tNGS),...
The pathogenic factors of the complex epidemic disorder-obesity, have expanded from genetic background, endocrine factors, abnormal feeding behaviors, and direct neural control adipose tissue physiology. As a chronic metabolic disease, it is important to find new potential therapeutic targets locate sensitive time window for intervention. In this study, we focus on early stage high-fat diet mouse model: short-term 3-week treatment. Our results showed that HFD can already induce significant...
Cellular energy metabolism plays a crucial role in the regulation of macrophage polarization and execution immune functions. A recent study showed that Slc6a8-mediated creatine uptake from exogenous supplementation modulates polarization, yet little is known about de novo biosynthesis pathway polarization. Here, we observed glycine amidinotransferase (GATM), rate-limiting enzyme for synthesis, was upregulated alternative (M2) polarized macrophages, dependent on transcriptional factor STAT6,...
Sensitive and specific fluorescence imaging-guided photothermal therapy (PTT) with high-efficiency is of essential importance still a challenge for nanotheranostics. To address these issues, we developed activatable ultrasmall gold nanorods (AUGNRs) to realize "off-on" switched efficient PTT. Herein, the GNRs an small size (∼4 nm) were set as PTT platform due their distinct absorption-dominant characteristics, generating enhanced conversion efficiency. A near infrared (NIR) dye, Cy5, was...
Objectives. Comparisons between remote magnetic (RMN) and manual catheter navigation for atrial fibrillation (AF) ablation have earlier been reported with controversial results. However, these reports were based on generations of the RMN system. Design. To evaluate outcomes most current system AF in a larger patient population longer follow-up time, 112 patients (78 paroxysmal, 34 persistent) who underwent utilizing (RMN group) compared to 102 (72 30 technique (Manual group). Results. The...
Background Cardiac resynchronization therapy (CRT) with or without a defibrillator has positive effect on mortality and morbidity for patients heart failure. However, comparisons between CRT‐defibrillators (CRT‐D) CRT‐pacemakers (CRT‐P) are relatively scarce outside the clinical trial setting. This study aimed to assess baseline characteristics in relation long‐term prognosis treated CRT, investigate potential benefit of CRT‐D versus CRT‐P. Methods Data were retrospectively collected from...
Background: Mediated by innate immune cells, inflammation is an underlying presence in the pathogenesis of numerous pulmonary diseases. Macrophages play a critical role mediating initial response to infection lungs. When there excessive activation macrophages, hyper-production inflammatory factors occurs, with as ultimate result. Wogonoside, bioactive flavonoid glycoside, has been reported alleviate inflammation. However, mechanism anti-inflammatory effect wogonoside not yet clarified....