A5086175851- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Genetic and Kidney Cyst Diseases
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Folate and B Vitamins Research
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
- Platelet Disorders and Treatments
- Acute Lymphoblastic Leukemia research
- Medical Imaging and Pathology Studies
- Immune cells in cancer
- Immune Response and Inflammation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA modifications and cancer
- Immunodeficiency and Autoimmune Disorders
- Mesenchymal stem cell research
- Cancer Genomics and Diagnostics
- Neonatal Respiratory Health Research
- Cytokine Signaling Pathways and Interactions
- Zebrafish Biomedical Research Applications
- Chronic Myeloid Leukemia Treatments
- Cell Adhesion Molecules Research
- Erythrocyte Function and Pathophysiology
Karolinska Institutet
2016-2025
Karolinska University Hospital
2014-2025
MRC Weatherall Institute of Molecular Medicine
2014-2024
University of Oxford
2015-2024
Indiana University Bloomington
2024
Janssen (Germany)
2024
John Radcliffe Hospital
2012-2023
Medical Research Council
2011-2023
Stockholm University College of Music Education
2023
MRC Human Immunology Unit
2023
Macrophage Development Rewritten Macrophages provide protection against a wide variety of infections and critically shape the inflammatory environment in many tissues. These cells come flavors, as determined by differences gene expression, cell surface phenotype specific function. Schulz et al. (p. 86 , published online 22 March) investigated whether adult macrophages all share common developmental origin. Immune cells, including most macrophages, are widely thought to arise from...
The role of autophagy, a lysosomal degradation pathway which prevents cellular damage, in the maintenance adult mouse hematopoietic stem cells (HSCs) remains unknown. Although normal HSCs sustain life-long hematopoiesis, malignant transformation leads to leukemia. Therefore, mechanisms protecting from damage are essential prevent malignancies. In this study, we crippled autophagy by conditionally deleting gene Atg7 system. This resulted loss HSC functions, severe myeloproliferation, and...
Abstract Murine bone marrow cells expressing the cell surface Ag RB6-8C5 were identified by fluorescence-activated cell-sorting analysis using a rat IgG mAb. The fluorescent intensity of was variable on cells. This made it possible to separate into distinct subpopulations, RB6-8C5neg, RB6-8C5lo, and RB6-8C5hi Morphologic sorted populations demonstrated that expressed myeloid expression increases with granulocyte maturation, whereas is transient in monocytic lineage. enriched for end-stage...
Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine, acting through the TNF-R1 and TNF-R2 receptors. The two receptors have been proposed to mediate distinct TNF-α effects in CNS, contributing neuronal damage being neuroprotective. Whether its play any role for neurogenesis adult brain unclear. Here we used mouse models with loss of function establish whether signaling these could influence hippocampal vivo under basal conditions, as well after status epilepticus (SE), which...
Abstract Neural stem cells (NSCs) in the adult rat subventricular zone (SVZ) generate new striatal neurons during several months after ischemic stroke. Whether microglial response associated with injury extends into SVZ and influences neuroblast production is unknown. Here, we demonstrate increased numbers of activated microglia ipsilateral concomitant migration striatum at 2, 6, 16 weeks, maximum 6 following 2 h middle cerebral artery occlusion rats. In peri‐infarct striatum, peaked already...
Cellular cardiomyoplasty is an attractive option for the treatment of severe heart failure. It is, however, still unclear and controversial which most promising cell source. Therefore, we investigated examined fate functional impact bone marrow (BM) cells embryonic stem (ES cell)–derived cardiomyocytes after transplantation into infarcted mouse heart. This proved particularly challenging ES cells, as their enrichment long-term engraftment tumorigenicity are poorly understood. We generated...
Abstract Aged haematopoietic stem cells (HSCs) generate more myeloid and fewer lymphoid compared with young HSCs, contributing to decreased adaptive immunity in aged individuals. However, it is not known how intrinsic changes HSCs shifts the balance between biased HSC subsets each contribute altered lineage output. Here, by analysing transcriptomes function at single-cell level, we identify increased molecular platelet priming functional bias as predominant age-dependent change including a...
Rationale: It is now recognized that macrophages residing within developing and adult tissues are derived from diverse progenitors including those of embryonic origin. Although the functions in organisms well studied, during organ development remain largely undefined. Moreover, it unclear whether distinct macrophage lineages have differing functions. Objective: To address these issues, we investigated subsets resident heart, an replete with embryonic-derived macrophages. Methods Results:...