A5025436759- Epigenetics and DNA Methylation
- Image Processing Techniques and Applications
- Autophagy in Disease and Therapy
- Cell Image Analysis Techniques
- Stress Responses and Cortisol
- Spectroscopy Techniques in Biomedical and Chemical Research
- Medical Image Segmentation Techniques
- Mesenchymal stem cell research
- Cannabis and Cannabinoid Research
- Single-cell and spatial transcriptomics
- Advanced Fluorescence Microscopy Techniques
- Neuroendocrine regulation and behavior
- Advanced Biosensing Techniques and Applications
- Reproductive System and Pregnancy
University of Connecticut
2023-2025
National Institute for Health Research
2011
Centre for Human Genetics
2011
University of Oxford
2011
John Radcliffe Hospital
2011
Institute of Molecular Medicine
2011
The role of autophagy, a lysosomal degradation pathway which prevents cellular damage, in the maintenance adult mouse hematopoietic stem cells (HSCs) remains unknown. Although normal HSCs sustain life-long hematopoiesis, malignant transformation leads to leukemia. Therefore, mechanisms protecting from damage are essential prevent malignancies. In this study, we crippled autophagy by conditionally deleting gene Atg7 system. This resulted loss HSC functions, severe myeloproliferation, and...
3D image registration is essential in computer vision, medical imaging, and robotics. By aligning images from different perspectives into a single coordinate system, this approach provides consistent viewpoint for analysis. Using accurate alignment, we may compare, evaluate, integrate data contexts. This paper describes new method to register or z-stack microscopy image. It uses hybrid of traditional deep learning methods feature extraction adaptive likelihood-based finding outliers. The...
Abstract The exclusion of female subjects from preclinical neuroscience research has traditionally been justified in part by concerns about potential effects cycling ovarian hormones on brain function. There is evidence that some behavioral and neurobiological measures do change over the estrous cycle and, as use becomes increasingly routine, there a greater demand for accessible cycle‐tracking methods. Conventional staging requires expert training qualitative interpretation vaginal cytology...
In various applications, such as computer vision, medical imaging, and robotics, three-dimensional (3D) image registration is a significant step. It enables the alignment of datasets into single coordinate system, consequently providing consistent perspective that allows further analysis. By precisely aligning images, we can compare, analyze, combine data collected in different situations. This paper presents novel approach for 3D or z-stack microscopy registration, utilizing combination...
The molecular organization of cells and tissue is challenging to study due the inefficiency multiplexed labeling methods limited options for combining microscopy modalities in a single specimen, especially when high spatial resolution needed. Here we describe ultraplex microscopy, which combines serial multiplexing, ultrathin sectioning, reversible embedding circumvent incompatibilities between imaging techniques, enhance resolution, expand multiplexing capacity within across modalities....