A5101656921- Liver Disease Diagnosis and Treatment
- Trace Elements in Health
- Hormonal Regulation and Hypertension
- IL-33, ST2, and ILC Pathways
- Inflammasome and immune disorders
- Pancreatitis Pathology and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Asthma and respiratory diseases
- Cell death mechanisms and regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural Antidiabetic Agents Studies
- Biochemical effects in animals
- Liver physiology and pathology
- Occupational exposure and asthma
- Mitochondrial Function and Pathology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Blood properties and coagulation
- Burn Injury Management and Outcomes
- Fatty Acid Research and Health
- Thermal Regulation in Medicine
- Galectins and Cancer Biology
- Occupational and environmental lung diseases
- Skin Protection and Aging
- Chronic Kidney Disease and Diabetes
- Nuclear Structure and Function
Wuhan No.1 Hospital
2022
State Key Laboratory of Respiratory Disease
2018-2021
Second Affiliated Hospital of Guangzhou Medical University
2018-2021
Guangzhou Medical University
2018-2021
Third Affiliated Hospital of Inner Mongolia Medical College
2021
Inner Mongolia Medical University
2021
Baogang Group (China)
2019
Guangxi Medical University
2013-2018
First Affiliated Hospital of GuangXi Medical University
2016-2018
First People's Hospital of Nanning
2016
Abstract Multiple studies have addressed the vital role of Nod-like receptor protein 3(NLRP3)/caspase-1/IL-1β signaling in asthma. Yet, NLRP3/caspase-1 toluene diisocyanate (TDI)-induced asthma is still obscure. The aim this study to investigate axis TDI-induced Using an established murine model as described previously, we gave asthmatic mice a highly selective NLRP3 inhibitor, MCC950, well specific caspase-1 inhibitors VX-765 and Ac-YVAD-CHO for therapeutic purposes. Airway resistance was...
Synopsis The impact of troposphere ozone (O 3 ), the major oxidant in photochemical smog, on overall wellbeing skin is considerable interest. To date, limited information available O human skin. Using a specially designed exposure chamber, we provide first evidence that to (0.8 ppm, 2‐h time‐weighted average) significantly reduced vitamin E by 70% and concomitantly increased lipid hydroperoxides 2.3 fold superficial stratum corneum (SC). Although dose used here resident microflora population...
Abstract Necroptosis of intestinal epithelial cells has been indicated to play an important role in the pathogenesis inflammatory bowel disease (IBD). The identification dysregulated proteins that can regulate necroptosis dextran sulfate sodium (DSS)-induced colitis is key rational design therapeutic strategies for colitis. Through tandem mass tag (TMT)-based quantitative proteomics, HtrA2 was found be downregulated colon DSS-treated mice. UCF-101, a specific serine protease inhibitor HtrA2,...
Background & AimsIncreased vascular permeability (VP) has been indicated to play an important role in the pathogenesis of inflammatory bowel disease (IBD). However, pathological causes increased intestinal VP IBD remain largely unknown.MethodFibrinogen level was measured dextran sulphate sodium (DSS)-induced colitis and patients with ulcerative colitis. Gly-Pro-Arg-Pro acetate (GPRP), Fg inhibitor, used detect effect inhibition on DSS-induced colitis, as by tissue damage, cytokine release...
Abstract Alveolar epithelial injury is one of the important pathological changes in idiopathic pulmonary interstitial fibrosis (IPF), but regulatory mechanism remains unclear. Here, we reported that alveolar type-II cells (AT II) play roles process fibrosis. Through iTRAQ (isobaric tagging for relative and absolute quantification) quantitative proteomics, TSSK4 was identified to be upregulated bleomycin-induced fibrotic mice model, which further confirmed clinical IPF patients’ tissue...
Abstract A dramatic increase in the incidence of inflammatory bowel disease (IBD) has been observed past two decades, mainly developed countries and also developing regions. Necroptosis found to play an important role pathogenesis IBD, suggesting its inhibitors are promising clinic. However, clinical drugs targeting necroptosis seriously lacking. Through screening a compound library that contains 611 inhibitors, pan-RAF inhibitor LY3009120 was be as inhibitor. inhibited vitro, inhibition...
Averrhoa carambola L. (Oxalidaceae) root (ACLR) has a long history of use in traditional Chinese medicine for treating diabetes and diabetic nephropathy (DN). (±)-Lyoniresinol 3α-O-β-D-glucopyranoside (LGP1, LGP2) were two chiral lignan glucosides that isolated from the ACLR. The purpose this study was to investigate effect LGP1 LGP2-mediated hypoglycaemia on renal injury streptozotocin (STZ)-induced mice. STZ-induced mice administrated LGP2 orally (20, 40, 80 mg/kg body weight/d) 14 days....
Accumulating evidence has suggested that toll-like receptor 4 (TLR4) is critically involved in the pathogenesis of asthma. The aim this study was to investigate role TLR4 toluene diisocyanate (TDI)-induced allergic airway inflammation.TLR4-/- and wild-type (WT) C57BL/10J mice were sensitized challenged with TDI generate a TDI-induced asthma model. B-cell lymphoma 2 (Bcl-2) inhibitors, ABT-199 (4 mg/kg) ABT-737 mg/kg), intranasally given TDI-exposed TLR4-/- after each challenge.TDI exposure...
Abstract Gastric cancer (GC) has one of the highest tumor incidences worldwide. Heat shock protein 70 (HSP70) is highly expressed and plays a critical role in occurrence, progression, metastasis, poor prognosis, drug resistance GC. However, underlying mechanisms HSP70 are not clear. To explore regulatory GC, we performed cell counting kit‐8 (CCK‐8) EdU staining assays to assess proliferation; immunohistochemistry western blot analyses expression; coimmunoprecipitation (Co‐IP) interactions...
Renal sympathetic nerve activity has an important role in renal disease-associated hypertension and the modulation of fluid homeostasis. In present study, changes function sodium/potassium handling were investigated groups 12-week-old male, spontaneously hypertensive rats with denervation (RDNX group) or sham (sham group). The RDNX group excreted significantly more sodium than during 2-week observation period (P<0.05). Following bilateral denervation, fractional lithium excretion was...
Ozone, the main component of photochemical smog and air pollution, can damage skin by oxidizing stratum corneum enzymes, lipids structural proteins. We have developed a rapid screening assay to determine free radical scavenging capacity various active ingredients that are frequently used in personal care products. Several known antioxidants including vitamin C, E analog Trolox, walnut seed extract, lipoic acid ergothioneine inner salt were assayed for their ability neutralize ozone-induced...
To determine whether the sympathetic nerve plays a role in regulation of Na+-H+ exchange (NHE) kidney spontaneously hypertensive rats (SHR), we investigated expression NHE and regulatory protein family (NHERF) denervated kidneys compared with intact kidneys. Twelve-week-old male SHR age-matched Wistar Kyoto (WKY) were used. randomly assigned to renal (RDNX, n = 8) or Sham (n groups. The mRNA NHE1, NHE3, NHERF1 NHERF2 assessed Following denervation, immunohistochemistry western blot analysis...
Abstract Necroptosis of intestinal epithelial cells has been indicated to play an important role in the pathogenesis inflammatory bowel disease (IBD). The identification dysregulated proteins that can regulate necroptosis dextran sulfate sodium (DSS)-induced colitis is key rational design therapeutic strategies for colitis. Through Tandem Mass Tag (TMT)-based quantitative proteomics, HtrA2 was found be downregulated colon DSS-treated mice. UCF-101, a specific serine protease inhibitor HtrA2,...
Objective To explore the effects of staged rehabilitation exercise on quality life and hip function in femoral neck fracture patients after operation. Methods From January 2018 to 2019, we selected 100 at Baogang Hospital Inner Mongolia by convenience sampling. All were randomly divided into experimental group control group, 50 cases each group. Control carried out routine exercise, while implemented rehabilitation. We compared life, pain, incidence complication between two...
Abstract Aims Irisin is a newly discovered actin that has been shown to be effective against inflammation-related symptoms. The aim of this study was investigate the influence on LPS-induced inflammation in vitro and role mitogen-activated protein kinase (MAPK) pathway protecting effect LPS-stimulated RAW 264.7 macrophages. Methods Cell viability assessed using MTT assay flow cytometry, cell morphology measured by optical microscope, IL-12 IL-23 were detected Elisa, levels related proteins...