A5004408788- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Vestibular and auditory disorders
- Zebrafish Biomedical Research Applications
- Hearing, Cochlea, Tinnitus, Genetics
- Biochemical effects in animals
- Neurological Disorders and Treatments
- Plant-based Medicinal Research
- Adenosine and Purinergic Signaling
- Angiogenesis and VEGF in Cancer
- Retinal Development and Disorders
- Cytokine Signaling Pathways and Interactions
- Spinal Cord Injury Research
- Berberine and alkaloids research
- EEG and Brain-Computer Interfaces
- NF-κB Signaling Pathways
- Metal-Catalyzed Oxygenation Mechanisms
- Pharmacological Effects of Natural Compounds
- Apelin-related biomedical research
- Retinoids in leukemia and cellular processes
- Inflammation biomarkers and pathways
- Sleep and Work-Related Fatigue
- Lymphatic System and Diseases
- Computational Drug Discovery Methods
Southwest Medical University
2016-2023
University of Electronic Science and Technology of China
2023
First Affiliated Hospital of Sichuan Medical University
2023
Chinese People's Liberation Army
2023
Affiliated Hospital of Nantong University
2022
Huaihua University
2022
Nantong University
2022
Hong Kong Polytechnic University
2019-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2020
Abstract Background Microglia, the innate immune cells in central nervous system, play an essential role brain homeostasis, neuroinflammation and infections. Dysregulated microglia, on other hand, are associated with neurodegenerative diseases, yet mechanisms underlying pro-inflammatory gene expression microglia incompletely understood. Methods We investigated of actin-associated protein tropomyosin 1 (TPM1) regulating phenotype retina by using a combination cell culture,...
Abstract The molecular mechanisms underlying functional decline during normal brain aging are poorly understood. Here, we identified the actin‐associated protein tropomyosin 1 (TPM1) as a new systemic pro‐aging factor associated with function deficits in retinas. Heterochronic parabiosis and blood plasma treatment confirmed that factors regulated age‐related inflammatory responses ectopic dendritic sprouting of rod bipolar (RBC) horizontal (HC) cells retina. Proteomic analysis revealed TPM1...
The dysfunction of articular chondrocytes is a crucial step in rheumatoid arthritis (RA) pathogenesis while its molecular mechanisms are not fully known. This study was aimed to investigate the expression aquaporin 4 (AQP4) adjuvant-induced (AIA) rats and involvement AIA development.Thirty were divided into normal group (n = 15). Rat induced by intradermal injection complete Freund's adjuvant evaluated secondary paw swelling histological assessments on knee joint damage. Localization protein...
Objectives: Previous studies have shown that aquaporin 1 (AQP1) is up-regulated in synovium and cartilage of rheumatoid arthritis (RA) patients AQP1 may be involved joint swelling synovial inflammation. This study was aimed to investigate the potential therapeutic effect acetazolamide (AZ, an inhibitor) on rat adjuvant-induced (AIA) explore its related mechanisms.Materials methods: Rat AIA induced by complete Freund's adjuvant. The AZ evaluated secondary hind paw swelling, index, TNF-α IL-1β...
Abstract Background The gut mycobiome of patients with lung adenocarcinoma (LUAD) remains unexplored. This study aimed to characterize the in LUAD and evaluate potential fungi as non-invasive biomarkers for early diagnosis. Methods In total, 299 fecal samples from Beijing, Suzhou, Hainan were collected prospectively. Using internal transcribed spacer 2 sequencing, we profiled mycobiome. Five supervised machine learning algorithms trained on fungal signatures build an optimized prediction...
Background:Neural cell adhesion molecule L1 contributes to nervous system development and maintenance by promoting neuronal survival, neuritogenesis, axonal regrowth/sprouting, myelination, synapse formation plasticity. also enhances recovery after spinal cord injury ameliorates neur odegenerative processes in experimental rodent models. Aiming for clinical translation of into therapy we screened functionally characterized vitro the small organic phenelzine, which mimics characteristic...
Glycosaminoglycans such as chondroitin sulfate (CS) and dermatan (DS) are long chains of repeating disaccharide units, covalently linked to core proteins form proteoglycans. Proteoglycans can be cell membrane-bound or part the extracellular matrix. They important in a wide range biologic processes, including development, synaptic plasticity, regeneration after injury, well modulation growth factor signaling, migration, survival, proliferation. Synthesis CS DS Golgi apparatus is mediated by...
Angiopoietin-2 (Ang-2), a ligand of the Tie-2 receptor, plays an important role in maintaining endothelial cells and destabilizing blood vessels. Collateral artery growth (arteriogenesis) is key adaptive response to arterial occlusion. It unknown whether destabilization vessels by Ang-2 can affect arteriogenesis modulate mononuclear cell function. This study aimed investigate effects on collateral growth.Hindlimb ischaemia model was produced C57BL/6 mice femoral ligation. Blood flow...
The aim of the present study was to investigate whether hypoxia responsive element (HRE) could be used enhance suicide gene ( HSV‐tk ) expression and tumoricidal activity in radiation‐controlled therapy human lung adenocarcinoma xenografts. A chimeric promoter, HRE–Egr, generated by directly linking a 0.3‐kb fragment HRE 0.6‐kb Egr‐1 promoter. Retroviral vectors containing luciferase or driven HRE–Egr were constructed. cell line (A549) stably transfected with above using lipofectamine...
To explore the clinical significance of C1q tumor necrosis factor-related protein-9 (CTRP9) in patients with cerebral infarction. Our data showed that serum CTRP9 was significantly lower than control group, especially large artery atherosclerotic first decreased and even from day 4 to 10, then gradually elevated. Logistic regression analysis suggested high level a protective factor for Thus, could be further classification infarction provides potential option disease prevention...
Major depression (MD) is a major public health problem which has substantial impact on individuals and society. Although it usually treated with antidepressant in primary care, these therapies accompanied serious side effects. In the clinic of Chinese medicine, Xiao-Yao-San first option for MD little clear therapeutic effects, its mechanism obscure. this study, by integrating leading biomedical knowledge databases, though bioinformatics analysis, we explored potential MD. The analysis covers...
To investigate the role of apolipoprotein A5 (apoA5) in pathogenesis obesity-related hypertriglyceridemia and related therapeutic effects metformin. Methods: The ob/ob mice were treated with regular chow diet metformin for 4 weeks, levels hepatic triglyceride (TG) apoA5 measured. Hepatic IAR20 cells and/or siRNAs, then cellular TG contents expression determined. Results: High plasma found mice. positively correlated these Metformin could dose-dependently decrease also reduce expression,...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Li R, Zhang J, Jiang Y, Chen K. A case of generalized lichen planus pigmentosus: an atypical clinical variety. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2022;39(3):627-628. doi:10.5114/ada.2022.117524. APA Li, R., Zhang, J., Jiang, Y., & Chen, (2022). Alergologii, 39(3), 627-628. https://doi.org/10.5114/ada.2022.117524 Chicago Rong, Jia-an Yi-Qun Kun Chen. 2022. "A variety"....
Objective To study the effect of hyperbaric oxygen on anti-senility mice with Alzheimer disease.Methods Thirty male KM were randomly divided into 3 groups:the control group,the model group and HBO group.Models dementia successfully developed D-galactose (120 mg/kg) sodium nitrite (90 mg/kg).Escape latency times running across platform respectively determined by Morris water maze.The activity serum superoxide dismutase (SOD),glutathione peroxide (GSH-Px) content malondialdehyde (MDA) detected...