A5002095278- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- COVID-19 Clinical Research Studies
- IL-33, ST2, and ILC Pathways
- Contact Dermatitis and Allergies
- SARS-CoV-2 and COVID-19 Research
- Autophagy in Disease and Therapy
- Occupational exposure and asthma
- Advanced Proteomics Techniques and Applications
- SARS-CoV-2 detection and testing
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 epidemiological studies
- Mosquito-borne diseases and control
- Occupational and environmental lung diseases
- Vitamin D Research Studies
- Identification and Quantification in Food
- Extracellular vesicles in disease
- Machine Learning in Bioinformatics
State Key Laboratory of Respiratory Disease
2012-2024
Second Affiliated Hospital of Guangzhou Medical University
2012-2024
Guangzhou Medical University
2012-2024
Shanghai Jiao Tong University
2012
Abstract Summary: SORTALLER is an online allergen classifier based on family featured peptide (AFFP) dataset and normalized BLAST E-values, which establish the vectors for support vector machine (SVM). AFFPs are allergen-specific peptides panned from irredundant allergens harbor perfect information with noise fragments eliminated because of their similarity to non-allergens. performed significantly better than other existing software reached a balance high specificity (98.4%) sensitivity...
Abstract Alveolar epithelial injury is one of the important pathological changes in idiopathic pulmonary interstitial fibrosis (IPF), but regulatory mechanism remains unclear. Here, we reported that alveolar type-II cells (AT II) play roles process fibrosis. Through iTRAQ (isobaric tagging for relative and absolute quantification) quantitative proteomics, TSSK4 was identified to be upregulated bleomycin-induced fibrotic mice model, which further confirmed clinical IPF patients’ tissue...
Machine learning and weighted gene co-expression network analysis (WGCNA) have been widely used due to its well-known accuracy in the biological field. However, nature of a gene’s multiple functions, it is challenging locate exact genes involved complex diseases such as asthma. In this study, we combined machine WGCNA order analyze expression data asthma for better understanding associated pathogenesis. Specifically, role assigned screen out key development, while set up network. Our results...
The goal of this study is to investigate the probable intermediate hosts and allergenicity notorious virus SARS-CoV-2 understand how emerged. phylogenetic analysis spike proteins indicates that falls into various small subclades include a bat coronavirus RaTG13, suggesting bats as likely natural origin. Refined alignment protein in NCBI found several fragments are specific and/or SARS-CoV
Recent studies have indicated that the Zika virus (ZIKV) has a significant impact on fetal brain, and autophagy is contributing to host immune response defense against infection. Here, we demonstrate ZIKV infection triggered increased LC3 punctuation in mouse monocyte-macrophage cell line (RAW264.7), microglial (BV2), hindbrain tissues, proving occurrence of both vitro vivo . Interestingly, manual intervention autophagy, like deficiency inhibited by 3-MA, can reduce viral clearance RAW264.7...
Vast amounts of allergen sequence data have been accumulated, thus complicating the identification specific allergenic proteins when performing diagnostic allergy tests and immunotherapy. This study aims to rank importance/potency allergens so as logically reduce number and/or sources. Meta-analysis 62 sources used for intradermal testing on 3,335 allergic patients demonstrated that in southern China, mite, sesame, spiny amaranth, Pseudomonas aeruginosa , house dust account 88.0% 100%...
Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, is associated with various comorbidities, such as allergic diseases like rhinitis. However, the causal relationship potential metabolic mechanisms remain unclear. This study investigates association between inflammatory rhinitis, focusing on mediation through Mendelian randomization analysis. A two-sample analysis was conducted using datasets from European populations to evaluate relationships Additionally, 212...
SARS-CoV is believed to originate from civets and was thought have been eliminated as a threat after the 2003 outbreak. Here, we show that human (huSARS-CoV) originated directly bats, rather than civets, by cross-species jump in 1991, formed human-adapted strain 1998. Since then huSARS-CoV has evolved further into highly virulent strains with genotype T 29-nt deletion mutation, weakly C but without deletion. The former can cause pneumonia humans could be major causative pathogen of SARS...