A5073116605- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Urticaria and Related Conditions
- Healthcare and Venom Research
- Air Quality and Health Impacts
- Ocular Surface and Contact Lens
- Herbal Medicine Research Studies
- interferon and immune responses
- Eosinophilic Esophagitis
- Nasal Surgery and Airway Studies
- Galectins and Cancer Biology
- Cancer-related molecular mechanisms research
- Autoimmune Bullous Skin Diseases
- Circular RNAs in diseases
- Air Quality Monitoring and Forecasting
- Medicinal Plant Pharmacodynamics Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Toxin Mechanisms and Immunotoxins
- Climate Change and Health Impacts
- Respiratory and Cough-Related Research
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Contact Dermatitis and Allergies
Second Affiliated Hospital of Guangzhou Medical University
2015-2025
Guangzhou Medical University
2015-2025
State Key Laboratory of Respiratory Disease
2014-2024
A lower adherence rate existed in patients receiving allergen-specific immunotherapy due to its lengthy period and adverse effects even though it is the only curative treatment for IgE-mediated allergies. Therefore, exploring innovative routes necessary.
Abstract Asthma is a common allergic disease characterized by airway hypersensitivity and remodeling. Ferroptosis regulated death marked iron accumulation lipid peroxidation. Several environmental pollutants allergens have been shown to cause ferroptosis in epithelial cells, but the relationship between birch pollinosis asthma poorly defined. Here, for first time, we identified of type II alveolar cells mice with Bet v 1-induced asthma. Further analysis revealed that treatment ferrostatin-1...
Aim: Multicenter study to investigate the safety of mite extract product Novo-Helisen Depot, Strengths 1 3 (NHD3), as subcutaneous immunotherapy (SCIT), in Chinese children and adolescents with allergic rhinitis (AR) asthma (AA). Patients & methods: We evaluated SCIT-related adverse events (AEs) during NHD3 14-week initial therapy (5–11 years) (12–17 perennial symptomatic AR AA. Results: Among 3600 injections 250 patients, 361/3600 (10.0%) caused AEs 96/250 (38.4%) 321/3600 (8.9%) local...
Vast amounts of allergen sequence data have been accumulated, thus complicating the identification specific allergenic proteins when performing diagnostic allergy tests and immunotherapy. This study aims to rank importance/potency allergens so as logically reduce number and/or sources. Meta-analysis 62 sources used for intradermal testing on 3,335 allergic patients demonstrated that in southern China, mite, sesame, spiny amaranth, Pseudomonas aeruginosa , house dust account 88.0% 100%...
Background Real-world data of the subcutaneous immunotherapy (SCIT) with semi-depot house-dust mite (HDM) allergen extract (a HDM that contains a 50%-50% mixture Dermatophagoides pteronyssinus and farina) for allergic rhinitis asthma was unavailable in China until recently. Aim To investigate effectiveness safety HDM-SCIT Chinese patients. Methods A multicenter, single-arm, open-label, self-controlled study. patients or history symptoms from exposure were included received allergen-specific...
Aim . To investigate differences in the efficacy of sublingual immunotherapy with Dermatophagoides farinae drops monosensitized and polysensitized allergic rhinitis patients. Methods The patients enrolled study were treated for more than one year by (SLIT) using divided into a group (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>20</mml:mn></mml:math>) id="M2"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>30</mml:mn></mml:math>)....
Objective To investigate the distribution of Foxp3-924(rs2232365)genes in a Guangdong population and to explore association these genes with allergic conjunctivitis.Methods A total 103 unrelated healthy individuals Han nationality 80 patients conjunctivitis who were from same geographic region enrolled study.Foxp3-924(rs2232365) was genotyped by PCR-SSP technique.Results There no significant difference Foxp3-924 AA genotype frequencies between normal control group(32.5％ vs.23.3％,x2=1.92,P...
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Objective To evaluate the effect of desensitization therapy for dust mites allergic conjunctivitis. Methods From 2002 to 2007, prospective and case controlled trial was designed compare scores ocular itch hyperemia, levels serum specific IgE EOS before after 122 Results There were patients completed in compliance with evaluations. The decreased from (2.2± 1.1) (0.5± 0.3) (P 0.05), (0.119± 0.127) × 109/L(P<0.01) respectively therapy. 64.75% clinically cured, 31.97% them effective. 8 out...
Objective To explore in vivo and vitro detection of allergens the diagnosis allergic rhinitis. Methods The patients whose skin prick test(SPT)to Dermatophagoides tarinae was positive were simultaneously received serum specific IgE(SIgE). Results rate SIgE D2 93. 36% 211 with rhinitis, 97.74% which strong positive. Conclusions In is associated detection. Skin test can be primarily used for screening then sIgE to assess degree allergy, identify rhinitis accurately inexpensively. Key words:...
Objective To investigate the relationship of Tim-3 promotor-1541 C> T polymorphisms and allergic rhinitis .Methods The polymorphism C>T gene was screened by PCR-RELP.Results frequency in AR group as followed; C/C, C/T, T/T genotype frequency: 0.9733, 0, 0.0227, C, Genefrequency: 0.9733 , 0.0227.the control C>TC/C, 0.8922 0.0882, 0.196; enefrequency: 0. 9363、0.0637, There were no significant differenees frequencies promotor-1541C>T between patients group(P rhinitis. Key words: Aallergic...