A5100374632- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Cancer Cells and Metastasis
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Glycosylation and Glycoproteins Research
- Crop Yield and Soil Fertility
- Metabolism, Diabetes, and Cancer
- Autophagy in Disease and Therapy
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Hepatitis C virus research
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Dye analysis and toxicity
- Intracerebral and Subarachnoid Hemorrhage Research
- Enhanced Recovery After Surgery
- Traditional Chinese Medicine Analysis
Shanxi Agricultural University
2024-2025
University of Jinan
2025
Nanjing Medical University
2022-2025
Shihezi University
2025
Taizhou People's Hospital
2015-2024
Tianjin Medical University Cancer Institute and Hospital
2022-2024
Urban Planning & Design Institute of Shenzhen (China)
2024
Guangzhou Medical University
2023-2024
Beijing Institute of Education
2024
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2024
Abstract Objectives Stereotactic body radiotherapy ( SBRT) is a treatment option for patients with early-stage non-small cell lung cancer (NSCLC) who are unfit surgery. Some may experience distant metastasis. This study aimed to develop and validate radiomics model predicting metastasis in NSCLC treated SBRT. Methods Patients at five institutions were enrolled this study. Radiomics features extracted based on the PET/CT images. After feature selection training set (from Tianjin), CT-based...
Drip fertigation (DF) can improve yield, water use efficiency (WUE), and nitrogen (NUE, grain production per unit of the sum soil inherent mineral N fertilizer N), as well reduce risk environmental pollution compared with flood irrigation broadcast (FB). Previously, we showed that DF enhanced response yield to topdressing rate (NTR), but underlying mechanisms associated supply, root architecture, uptake remain unclear. We conducted a field experiment by testing six treatments (no applied,...
AimsRecently, interleukin (IL)-9 was found to be involved in the pathogenesis of many inflammatory diseases. Here, we tested whether IL-9 related atherosclerosis and investigated underlying mechanisms.
Pancreatic cancer is characterized by extremely poor prognosis because of early recurrence and metastasis, increasing evidence supports the critical role microRNA in progression. Here we identified that microRNA-34b functioned as a tumor-suppressing targeting oncogenic Smad3 pancreatic cancer. As hypovascular tumor with potential endoplasmic reticulum stress microenvironment, miR-34b was silenced after ER inducer thapsigargin (Tg) treatment negatively regulated chaperone glucose protein 78...
Accumulating evidence indicates that microRNAs (miRNAs) have great potential as tumor biomarkers and therapeutic agents owing to their functions in tumorigenesis cancer progression. Aberrant expression of miR-1247 has been found several cancers is predicted play an important role the pathological processes pancreatic by miRNA-regulated network analysis. We investigated profile tissue microarray situ hybridization was significantly down-regulated tissues compared matched benign tissues. High...
Most patients with pancreatic ductal adenocarcinoma (PDAC) have unresectable cancers a dismal prognosis, in which cohort chemotherapy is the primary treatment. T cell immune adaption critical for tumor escape and prognosis of this disease. The present study aimed to determine correlation between peripheral subset distribution PDAC their response chemotherapy. Two hundred twelve were included whose blood samples collected analysis subsets, including CD3+, CD4+, CD8+, CD8+CD28+ CD4+CD25+CD127...
In the present study, function of microRNA (miR)-214 on diabetic nephropathy (DN) and diabetes proximal tubular cells was investigated. Reverse transcription-quantitative polymerase chain reaction used measure expression miR-214 in rats with DN ELISA performed to oxidative stress ROS levels. Results indicated that peripheral blood significantly decreased DN. The vitro model upregulation reactive oxygen species (ROS) levels, but increased uncoupling protein 2 (UCP2), phosphorylated (p)-Akt...
In the surgical treatment of urinary diseases, ureteral stents are commonly used interventional medical devices. Although polymer with polyurethane as main constituent widely in clinic, need for secondary surgery to remove them and their propensity cause bacterial infections greatly limit effectiveness. To satisfy clinical requirements, an electrospinning-based strategy fabricate PLGA silver@graphdiyne is innovated. Silver (Ag) nanoparticles uniformly loaded on surface graphdiyne (GDY)...
A lower adherence rate existed in patients receiving allergen-specific immunotherapy due to its lengthy period and adverse effects even though it is the only curative treatment for IgE-mediated allergies. Therefore, exploring innovative routes necessary.
Abstract Perioperative cognitive dysfunction is a common complication in stroke patients undergoing secondary surgeries. This study investigated the effects of tibial fracture internal fixation (TFIF) surgery on function and gut microbiota mice with history stroke. Using middle cerebral artery occlusion method to induce stroke, we assessed via fear conditioning test analyzed through 16S rRNA sequencing. Compared those normal groups, group that underwent TFIF was significantly impaired. Gut...
More than 90% of deaths due to breast cancer (BC) are metastasis-related complications, with invasive ductal carcinoma (IDC) the being most common pathologic type and highly susceptible metastasis distant organs. BC patients who develop metastases more likely have a poor prognosis quality life, so it is extremely important recognize diagnose whether occurred in IDC as early possible. In this study, we non-invasive classification system for detecting metastasis. We used Anaconda-Jupyter...
Solid pseudopapillary tumor of the pancreas (SPT) is a rare pancreatic disease with unique clinical manifestation. Although CTNNB1 gene mutations had been universally reported, genetic variation profiles SPT are largely unidentified. We conducted whole exome sequencing in nine patients to probe SPT-specific insertions and deletions (indels) single nucleotide polymorphisms (SNPs). In total, 54 SNPs 41 indels prominent variations were demonstrated through parallel sequencing. detected that...
Abstract Background The association between non-alcoholic fatty liver disease (NAFLD) and osteoarthritis (OA) has not been well elucidated. aim of the present study was to investigate NAFLD OA in US adults. Methods A cross-sectional performed on participants 2017–2018 National Health Nutrition Examination Survey (NHANES) cycle. defined by vibration-controlled transient elastography. diagnosis based self-reported data. Weighted multiple logistic regression models stratified analyses were...
Conventional water and nitrogen (N) management practice in north China, comprising flood irrigation N fertilizer broadcast (FB), limits sustainable wheat production. Drip fertigation (DF) has been widely adopted production recent years effectively improved yields. However, the responses of yield quality to topdressing rate (NTR) under DF are still unclear. This study determined NTR DF, as well assessing whether could synergistically increase quality. A field experiment was conducted China...
Introduction: Carnosine can suppress secondary complications in diabetes and show robust neuroprotective activity against neurodegenerative diseases. Here, we report that carnosine ameliorates diabetes-associated cognitive decline vivo through the modulation of autophagy. Methods: A high-fat diet (HFD) one intraperitoneal injection 30 mg/kg streptozotocin (STZ) were used to induce type 2 mellitus Sprague-Dawley rats. The rats randomly divided into five groups: control (CON), HFD/STZ, three...