A5004135808- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal Cancer Research and Treatment
- Renal cell carcinoma treatment
- Esophageal and GI Pathology
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Genomics and Diagnostics
- Phagocytosis and Immune Regulation
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Lymphoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bladder and Urothelial Cancer Treatments
- Cancer, Lipids, and Metabolism
- Gastrointestinal disorders and treatments
- Radiomics and Machine Learning in Medical Imaging
- Metastasis and carcinoma case studies
- Cancer Treatment and Pharmacology
The University of Texas Health Science Center at Houston
2013-2024
Memorial Hermann
2011-2014
The University of Texas at Austin
2014
Oxford BioMedica (United Kingdom)
2009
The University of Texas MD Anderson Cancer Center
2007-2008
Weatherford College
2008
Pancreatectomy is associated with significant morbidity and unpredictable outcome, few diagnostic tools to determine, which patients gain the most benefit from this treatment, especially before operation. This study aimed define a preoperative signature panel of serum markers indicate response pancreatectomy for pancreatic cancer. Over 1000 cancer treated at two independent high-volume institutions were included in divided into three groups, including resected, locally advanced metastatic....
Background: Mipsagargin (G-202) is a thapsigargin-based prodrug with cytotoxic activity masked by peptide that cleaved prostate-specific membrane antigen (PSMA), protease expressed in prostate cancer cells and the endothelium of tumor vasculature. It was hypothesized PSMA-mediated activation mipsagargin would result disruption vasculature, leading to decrease blood flow, direct effects on cells, resulting anti-tumor activity. Method: In this open-label, Phase II study, administered...
Abstract Long term prognosis and 5-year survival for pancreatic adenocarcinoma (PDAC) remains suboptimal. Endoscopic ultrasound (EUS) guided RFA (EUS-RFA) is an emerging technology limited data exist regarding safety long-term outcomes. The aim of this study to report safety-profile, feasibility outcomes EUS-RFA advanced PDAC. Prospective review patients with diagnosis locally-advanced or metastatic PDAC undergoing between October 2016 March 2018 follow up (> 30 months). Study underwent a...
Pancreatic ductal adenocarcinoma (PDAC) presents a 5-year overall survival rate of 11%, despite efforts to improve clinical outcomes in the past two decades. Therapeutic resistance is hallmark this disease, due its dense and suppressive tumor microenvironment (TME). Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) promising local ablative potential immunomodulatory therapy for PDAC. In study, we performed RFA preclinical tumor-bearing KrasG12D; Trp53R172H/+; Pdx1:Cre (KPC)...
CD44 is a transmembrane glycoprotein and surface receptor for hyaluronan that involved in the response of cells to their microenvironment.CD44 splice variants play roles carcinogenesis, differentiation, lymph node metastasis are predictive prognosis various carcinomas, including gastric cancer.Current data suggest tissue stem cancer both express variant, CD44v9.Overall, regarding alterations occur its acute chronic infection with Helicobacter pylori scant poorly elucidated terms possible...
Pancreatic cancer is characterized by extremely poor prognosis because of early recurrence and metastasis, increasing evidence supports the critical role microRNA in progression. Here we identified that microRNA-34b functioned as a tumor-suppressing targeting oncogenic Smad3 pancreatic cancer. As hypovascular tumor with potential endoplasmic reticulum stress microenvironment, miR-34b was silenced after ER inducer thapsigargin (Tg) treatment negatively regulated chaperone glucose protein 78...
Abstract BACKGROUND. Lymphovascular invasion (LVI) and/or lymph node metastases (LNM) adversely influence the overall survival (OS) of patients with T1 esophageal adenocarcinoma. Although endoscopic therapy may be adequate for T1a cancer, T1b cancer require esophagectomy/lymphadenectomy. The authors hypothesized that LVI status would subclassify cancers and facilitate new therapeutic strategies. METHODS. Ninety‐nine consecutive adenocarcinoma were analyzed after they underwent LNM was...
Deregulated expression of zinc transporters was linked to several cancers. However, the detailed profile all human in normal organs and cancer, especially pancreatic cancer is not available. The objectives this study are investigate complete patterns 14 ZIP 10 ZnT a large number tissues cell lines. We examined 22 different tissues, 11 pairs clinical specimens surrounding normal/benign as well established lines plus ductal epithelium (HPDE) cells, using real time RT-PCR immunohistochemistry....
The Von-Hippel-Lindau (VHL) gene, acting as a tumor suppressor, plays crucial role in the tumorigenesis of clear cell renal carcinoma (ccRCC). Approximately 90% individuals with advanced ccRCC exhibit somatic mutations VHL gene. Belzutifan, orally administered small-molecule inhibitor hypoxia-induced factor-2α, has demonstrated promising efficacy solid tumors associated germline loss-of-function VHL, including ccRCC. However, its impact on cases or sporadic remains unclear. Here, we present...
Gastric cancer ranks as the fifth leading cause of global incidences, exhibiting varied prevalence influenced by geographical, ethnic, and lifestyle factors, well Helicobacter pylori infection. The ATM gene on chromosome 11q22 is vital for genomic stability an initiator DNA damage response, mutations in this have been associated with various cancers. Poly ADP-ribose polymerase (PARP) inhibitors, such olaparib, shown efficacy cancers homologous recombination repair deficiencies, notably those...
Urothelial carcinoma of the upper urinary tract (UTUC) presents a significant clinical challenge, often requiring aggressive surgical intervention for optimal management. We present case an 84-year-old woman with recurrent high-grade papillary UTUC left renal pelvis, refractory to prior endourologic interventions, who underwent neoadjuvant treatment pembrolizumab and enfortumab vedotin (Pembro/EV) due contraindications cisplatin therapy. Following favorable response therapy, patient...
Abstract BACKGROUND. With increasing emphasis on endoscopic therapy (ET) for T1 esophageal carcinoma, the identification of low‐risk patients is critical. It was hypothesized that ultrasonography (EUS) in concert with detailed histopathologic evaluation would identify cancers an appropriate but organ‐preserving strategy. METHODS. All who had pretreatment EUS and underwent esophagectomy as primary cancer between 1999 2006 were analyzed retrospectively. The accuracy predicting correct...
e16056 Background: Everolimus, a mTOR inhibitor and Sorafenib, Raf kinase had shown their efficacy in RCC, as single agents. Combining these two active agents could have potential additive or synergistic effects. We conducted phase I study to evaluate the maximum tolerated dose (MTD) of this combination patients with progressive mRCC. Methods: Patients predominantly clear cell measurable diseases on prior treatments including immunotherapy, TKI and/or Everolimus. were evaluated weekly for...