A5084634997- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related Molecular Pathways
- Lung Cancer Diagnosis and Treatment
- Immune cells in cancer
- Cell death mechanisms and regulation
- Advanced X-ray and CT Imaging
- Colorectal Cancer Screening and Detection
- Machine Learning in Bioinformatics
- Autophagy in Disease and Therapy
- Colorectal Cancer Treatments and Studies
- Chronic Lymphocytic Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Medical Imaging Techniques and Applications
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Melanoma and MAPK Pathways
- Reproductive System and Pregnancy
- Cancer Diagnosis and Treatment
- Caveolin-1 and cellular processes
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Multiple and Secondary Primary Cancers
Institute for Systems Biology
2024-2025
Fudan University Shanghai Cancer Center
2013-2024
Shanghai Medical College of Fudan University
2016
Fudan University
2013
Cancer Institute (WIA)
2013
The aim of this study was to assess the immune profile within microenvironment pancreatic ductal adenocarcinoma (PDAC), and investigate prognostic value intratumoral infiltrating immune/inflammatory cells (IICs) in patients after surgery.Eighteen phenotypic markers representing 11 types IIC protein products genes TP53, CDKN2A/p16 SMAD4/DPC4 were assessed by immunohistochemistry specimens from with cancer. expression IICs mutational status correlated tumour recurrence survival, results...
Pancreatic cancer is characterized by extremely poor prognosis because of early recurrence and metastasis, increasing evidence supports the critical role microRNA in progression. Here we identified that microRNA-34b functioned as a tumor-suppressing targeting oncogenic Smad3 pancreatic cancer. As hypovascular tumor with potential endoplasmic reticulum stress microenvironment, miR-34b was silenced after ER inducer thapsigargin (Tg) treatment negatively regulated chaperone glucose protein 78...
Accumulating evidence indicates that microRNAs (miRNAs) have great potential as tumor biomarkers and therapeutic agents owing to their functions in tumorigenesis cancer progression. Aberrant expression of miR-1247 has been found several cancers is predicted play an important role the pathological processes pancreatic by miRNA-regulated network analysis. We investigated profile tissue microarray situ hybridization was significantly down-regulated tissues compared matched benign tissues. High...
Pancreatic Adenocarcinoma (PDAC) is one of the most deadly malignant tumors worldwide. A variety mechanisms are involved in PDAC biological behaviors, which, immune escape may be a pivotal hallmark. HLA-G tolerant molecule implicated tumor and serves as prognostic biomarker tumors. Our study evaluated expression explored its clinical significance. In cohort 122 patients, 78 patents (63.9%) exhibited high level tissues. Multivariate analysis suggested that was an independent predictor for OS...
A major contributor to poor sensitivity anti-cancer kinase inhibitor therapy is drug-induced cellular adaptation, whereby remodeling of signaling and gene regulatory networks permits a drug-tolerant phenotype. Here, we resolve the scale kinetics critical subcellular events following oncogenic inhibition preceding cell cycle re-entry, using mass spectrometry-based phosphoproteomics RNA sequencing capture molecular snapshots within first minutes, hours, days BRAF exposure in human
The correlation between the loss of Profilin 1 (Pfn1) with tumor progression indicated that Pfn1 is a suppressor in human carcinoma. molecular mechanisms underlying suppression has yet to be elucidated. In this study, we showed overexpression sensitizes cancer cells apoptosis through typical intrinsic apoptotic pathway. Mechanistically, increased expression mediated upregulation p53R273H, one most common tumor-associated hotspot mutations p53, transactivation deletion tumorigenesis and...
MBD1 (Methyl-CpG Binding Domain Protein 1) is highly expressed in pancreatic cancer. Nrf2 (NF-E2 p45-related factor 2) and the 'antioxidant response element' (ARE)-driven genes that NRF2 controls are frequently upregulated cancer correlate with poor survival. Keap1 (Kelch-like ECH-associated protein a dominant negative regulator of reported to be epigenetically regulated by promoter methylation. However, role antioxidant its association KEAP1 has never been before remains unclear.We...
Pancreatic cancer has an extremely poor prognosis mainly due to lack of effective treatment options. Radiotherapy is mostly applied locally advanced cases, although tumor radioresistance limits the effectiveness. Profilin1, a novel suppressor gene, was reported be down-regulated in various cancers and associated with progression. The objective this study demonstrate how profilin1 affected pancreatic radiosensitivity. We showed cells after exposure radiation, re-expression suppressed cell...
Pancreatic cancer is a highly malignant tumor in the digestive system, and radical surgery only possible means to cure pancreatic at present. In past decade, has been developing rapidly, with various new technologies concepts emerging, among which use of minimally invasive techniques popularization neoadjuvant therapy are most notable. At same time, surgical treatment still long way go, many problems need be solved urgently. This article introduces 2024 edition NCCN guidelines, focusing on...