A5047144196- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Sarcoma Diagnosis and Treatment
- Lung Cancer Research Studies
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Cancer Research and Treatments
- Angiogenesis and VEGF in Cancer
- Virus-based gene therapy research
- Colorectal Cancer Treatments and Studies
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- CAR-T cell therapy research
- Cancer therapeutics and mechanisms
- Multiple and Secondary Primary Cancers
- Medical Imaging and Pathology Studies
- Vascular Tumors and Angiosarcomas
- Immunotherapy and Immune Responses
- Ovarian cancer diagnosis and treatment
- Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
The First Affiliated Hospital, Sun Yat-sen University
2025
Sun Yat-sen University
2021-2025
Fudan University Shanghai Cancer Center
2016-2025
Shanghai Medical College of Fudan University
2016-2025
Guangxi University
2024
Fudan University
2008-2024
Central European Institute of Technology
2024
Brno University of Technology
2024
Wuhan University of Technology
2022-2024
First Hospital of China Medical University
2024
Epidermal growth factor receptor (ErbB1, EGFR) is overexpressed in a variety of human cancer cells. It has been considered as rational target for drug delivery. To identify novel ligands with specific binding capabilities to EGFR, we screened phage display peptide library and found an enriched clone encoding the amino acid sequence YHWYGYTPQNVI (designated GE11). Competitive assay Scatchard analysis revealed that GE11 bound specifically efficiently EGFR dissociation constant approximately 22...
Lung cancer has become the most common type and caused deaths. adenocarcinoma (LUAD) is one of major lung cancer. This study aimed to establish a signature based on immune related genes that can predict patients' OS for LUAD.The expression data 976 LUAD patients from The Cancer Genome Atlas database (training set) Gene Expression Omnibus (four testing sets) 1534 ImmPort were used generation validation signature. glmnet Cox proportional hazards model was find best gene construct To assess...
Programmed cell death 1 (PD-1) is a key cell-surface receptor of CD28 superfamily that triggers inhibitory pathways to attenuate T-cell responses and promote tolerance. As crucial role in tumor immunity, PD-1 has been focus studies anti-cancer therapy. It approved tumors could exploit PD-1-dependent immune suppression for evasion. Considering the wide use glucocorticoids (GCs) therapy their immunosuppressive effects, we explored whether GCs influence expression PD-1. In our study, used...
Thoracic SMARCA4-deficient undifferentiated tumor (SD-UT) is a highly aggressive disease that nosologically related to but distinct from non-small cell lung cancer (SD-NSCLC). No standard treatment guidelines were established for SD-UT. This research explored the efficacy of different treatments in SD-UT, and prognostic, clinicopathologic genomic difference between SD-UT SD-NSCLC.Information 25 22 SD-NSCLC patients diagnosed treated Fudan University Shanghai Cancer Center January, 2017...
Ad5, adenovirus type 5; CNE, human nasopharyngeal carcinoma cell line; DLT, dose- limiting toxicity; GM-CSF, granulocyte-macrophage colony-stimulating factor; HNC, head and neck cancer; HRP,horseradish peroxidase; hTERT, telomerase reverse transcriptase; IL, interleukin; mtelo, modified promoter; MTD, maximum- tolerated dose; NCI-CTC, National Cancer Institute Common Toxicity Criteria; PCR, polymerase chain reaction; SDS-PAGE,sodium dodecyl sulphate polyacrylamide gel electrophoresis; SCHNC,...
Abstract The pervasive presence of micro/nanoplastics in the environment is a significant threat to ecosystems and human health, demanding effective remediation strategies. Traditional methods for extracting these pollutants from water are often inadequate, typically leaving environmentally harmful residues. In response, this work introduces an innovative approach using reconfigurable regenerable liquid metal microrobots (LiquidBots) that magnetically driven actively sequester aquatic...
Apatinib has potential as an effective and safe second-line or higher treatment for patients with chemotherapy-refractory esophageal squamous cell carcinoma (ESCC). Clinical safety is of concern when administering apatinib to uncontrolled lesions severe invasion trachea, bronchi, major blood vessels. To the best authors' knowledge, this first prospective phase II study investigate ESCC. could provide alternative option ESCC after first-line therapy in carefully selected patients.The aim was...
Abstract Purpose: This prospective single-arm phase II clinical trial aimed to evaluate the efficacy and safety of pegylated liposomal doxorubicin (PLD) combined with ifosfamide (IFO) as first-line treatment for patients advanced or metastatic soft-tissue sarcoma (STS). Patients Methods: received PLD (30 mg/m2; day 1) in combination IFO (1.8 g/m2; days 1–5) every 21 until disease progression, unacceptable toxicities, patient death, up six cycles. The primary endpoint was progression-free...
Checkpoint blockade combined with chemotherapy has become an important treatment option for lung cancer patients in clinical settings. However, biomarkers that effectively identify true responders remain lacking. We assessed the potential of plasma small extracellular vesicle (sEV)-derived microRNAs (miRNAs) as predicting and identifying to immunochemotherapy. A total 29 adenocarcinoma who received pembrolizumab pemetrexed carboplatin were enrolled. The efficacy evaluation revealed 24...
Lung cancer is the leading cause of cancer-related death in world. Previous report has identified ribosomal protein s15a (RPS15A) as a TGF-β-responsible gene lung adenocarcinoma cell line A549. In this study, we used specific si-RNA to downregulate RPS15A expression A549 cells and found that decreased significantly inhibited proliferation survival, determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colony formation assays. Moreover, were obviously accumulated G0/G1...
Abstract Considering the existence of immune‐desert in tumor microenvironment, clinical efficacy immunotherapy for lung adenocarcinoma is limited. This study aims to investigate ability transcription factors regulating immune microenvironment adenocarcinoma. RNA‐seq data were collected from The Cancer Genome Atlas database. relationships between and infiltrates assessed. Runt‐related factor 3 (RUNX3)‐associated pathways investigated by Kyoto Encyclopedia Genes Genomes, Gene Ontology, set...
Abstract Despite an overall decline in the incidence of new cases, lung adenocarcinoma continues to be a leading cause cancer death worldwide. Due lack gene expression signatures for risk and prognosis stratification adenocarcinoma, identifying novel molecular biomarkers therapeutic targets may potentially improve treatment. In current study, we investigate role USP53 adenocarcinoma. Bioinformatics analysis, quantitative reverse transcription polymerase chain reaction, Western blot were...
Freeze-dried restructured strawberry blocks (FRSB) have become an increasingly popular product. In this study, the effects of six edible gums (guar gum, gelatin, xanthan pectin, konjac and carrageenan) on FRSB quality were investigated. For FRSBs, compared with those in untreated samples, 0.6 % guar gum addition increased texture profile analysis (TPA) hardness, chewiness, puncture hardness by 29.59%, 174.86%, 25.34%, respectively; after 0.6% gelatin addition, sensory evaluation sourness was...
The aim of this prospective, pilot, single-arm phase II trial was to evaluate the safety and efficacy anlotinib combined with etoposide platinum-based regimens in first-line treatment extensive-stage small cell lung cancer (ES-SCLC).This study conducted at Fudan University Shanghai Cancer Center between December 2018 2020. All patients received standard chemotherapy (etoposide plus cisplatin/carboplatin) consisting four courses 12 mg once per day for 2 weeks followed by a one-week rest....
Current pemetrexed/platinum chemotherapy does not produce a satisfactory therapeutic response in advanced lung cancer patients. The aim of this study was to determine whether the administration gefitinib, tyrosine kinase inhibitor (TKI), intercalated with could improve efficacy chemotherapy-naïve patients non-squamous NSCLC without subsequent gefitinib maintenance therapy. Treatment-naïve stage IIIB or IV were randomly assigned receive pemetrexed (500 mg/m2 d1) and either cisplatin (75...
Dendritic cell- (DC-) based vaccination has emerged as a promising antitumour immunotherapy. However, overcoming immune tolerance and immunosuppression in the tumour microenvironment (TME) is still great challenge. Recent studies have shown that Rose Bengal (RB) can effectively induce immunogenic cell death (ICD) cancer cells, presenting whole antigens for DC processing presentation. synergistic effect of combining intralesional RB with immature DCs (RB-iDCs) remains unclear. In present...
This open-label, phase II study aimed to investigate the efficacy and safety of recombinant human endostatin (Rh-endostatin) plus irinotecan/cisplatin as second-line treatment in patients with advanced esophageal squamous cell carcinoma (ESCC). Eligible received 15mg/m2 Rh-endostatin a continuous intravenous pump infusion (7 days), 60mg/m2 irinotecan (days 1 8), cisplatin (day 1) every 3 weeks. The primary endpoint was progression-free survival (PFS). A total 50 were assessable for analysis....