A5103003286- Hematopoietic Stem Cell Transplantation
- Spinal Cord Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Cancer, Hypoxia, and Metabolism
- Syphilis Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- Sex work and related issues
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Shoulder Injury and Treatment
- Acute Myeloid Leukemia Research
- Cell Adhesion Molecules Research
- HIV, TB, and STIs Epidemiology
- Nerve injury and regeneration
- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
- Acute Lymphoblastic Leukemia research
- Cell death mechanisms and regulation
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Child and Adolescent Psychosocial and Emotional Development
- Peptidase Inhibition and Analysis
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Cancer Research and Treatments
National Center for Women and Children’s Health, China CDC
2012-2023
Hunan Cancer Hospital
2020-2023
Central South University
2020-2023
Harbin Medical University
2020-2023
People 's Hospital of Jilin Province
2023
Changchun University of Chinese Medicine
2023
University of Michigan
2015-2022
Second Affiliated Hospital of Harbin Medical University
2020
Bengbu Medical College
2011-2019
First Affiliated Hospital of Bengbu Medical College
2016
Propofol is the most commonly used sedative-hypnotic drug for noxious procedures, yet molecular targets underlying either its beneficial or toxic effects remain uncertain. In order to determine and thereby mechanisms of propofol, we have synthesized a photoactivateable analogue by substituting an alkyldiazirinyl moiety one isopropyl arms but in meta position. m-Azipropofol retains physical, biochemical, GABA(A) receptor modulatory, vivo activity propofol photoadducts amino acid residues...
Neural stem cell (NSC) transplantation is a major focus of current research for treatment spinal cord injury (SCI). However, it very important to promote the survival and differentiation NSCs into myelinating oligodendrocytes (OLs). In this study, myelin basic protein-activated T (MBP-T) cells were passively immunized improve SCI microenvironment. Olig2-overexpressing infected with lentivirus carrying enhanced green fluorescent protein (GFP) reporter gene generate Olig2-GFP-NSCs that...
Non-suicidal self-injury (NSSI) poses a significant public health concern, characterized by its high prevalence, recurrence, and association with suicide. While prior research has identified connection between negative life events (NLEs) NSSI, only few studies have longitudinally explored this relation underlying mechanisms. Our study investigated the longitudinal NLEs NSSI among Chinese college students. We also examined mediating role of rumination emotional regulation difficulties, as...
Our previous study showed that Schwann cells (SCs) promote survival, proliferation and migration of co-transplanted oligodendrocyte progenitor (OPCs) neurological recovery in rats with spinal cord injury (SCI). A subsequent vitro confirmed SCs modulated OPC by secreting platelet-derived growth factor (PDGF)-AA fibroblast factor-2 (FGF)-2. We also found PDGF-AA stimulated their differentiation into oligodendrocytes (OLs) at later stages. therefore speculated administration can exert the same...
The oncogenesis of cervical cancer is a multi-factor and multi-step process, major risk factors include oncogene activation with tumor suppressor gene inactivation, viral factors, immune factors. For example, the human papillomavirus (HPV) has been linked to occurrence cancer. At present, pathogenesis remains unclear. Fra-1 (Fos-related antigen 1, also known as FOSL1) member Fos family an important nuclear transcription factor that regulates normal cell growth, differentiation, apoptosis. In...
Fos-related antigen 1 (Fra-1) is a nuclear transcription factor that regulates cell growth, differentiation, and apoptosis. It involved in the proliferation, invasion, apoptosis epithelial mesenchymal transformation of malignant tumor cells. Fra-1 highly expressed gastric cancer (GC), affects cycle distribution GC cells, participates occurrence development. However, detailed mechanism unclear, such as identification Fra-1-interacting proteins their role pathogenesis. In this study, we...
In contrast to normal cells, cancer cells typically undergo metabolic reprogramming. Studies have shown that oncogenes play an important role in this CD38 is a multifunctional transmembrane protein expressed abnormally variety of tumor types. To investigate the effect and possible mechanism cervical provide new therapeutic target for treatment cancer, present study identified involved regulating cell metabolism cells. Liquid chromatography‑tandem mass spectrometry bioinformatic analyses...
Leukemic relapse is believed to be driven by transformed hematopoietic stem cells (HSC) that harbor oncogenic mutations or have lost tumor suppressor function. Recent comprehensive sequencing studies shown predicted activate Ras signaling are highly prevalent in hematologic malignancies and, notably, refractory and relapsed cases. To better understand what drives this clinical phenomenon, we expressed
Previous studies by our group have demonstrated that the transplantation of exogenous platelet-derived growth factor (PDGF)-AA-overexpressing oligodendrocyte progenitor cells (OPCs) promotes tissue repair and recovery neurological function in a rat model spinal cord injury (SCI). However, it remains unclear whether treatment with PDGF-AA also affects endogenous oligodendrocytes (OL) or even neurons, thus promoting further functional after SCI. In present study, we evaluated therapeutic...
Objective This study aimed to investigate the incidence and associated predictors of adverse pregnancy outcomes (APOs) among pregnant women infected with syphilis. Design Cox regression analysis. Setting China. Population or sample Pregnant who were tested for diagnosed syphilis during index delivered at a gestational age ≥28 weeks between 2016 2019. Methods Data extracted from China’s Information System Prevention Mother‐to‐Child Transmission Syphilis Management. Descriptive analysis...
CD90, also known as Thy‑1 cell surface antigen, is located on human chromosome 11q23.3, and encodes a glycosylphosphatidylinositol‑linked glycoprotein. CD90 serves key role in malignancy by regulating proliferation, metastasis angiogenesis. Gastric cancer one of the most common types malignancy. Patients with advanced gastric have poor prognosis. plays occurrence progression cancer. However, molecular mechanism currently unclear. In order to identify which affects biological behavior energy...
Abstract This study investigates the improvement of prevention mother-to-child transmission (PMTCT) Human Immunodeficiency Virus (HIV) in China during 2004–2011. A clinic-based prospective was conducted among HIV-positive pregnant women and their children eight counties across China. Associated factors were analyzed using regression analysis. total 1,387 HIV+ 1,377 HIV-exposed infants enrolled. The proportion who received HIV testing increased significantly from 45.1% to 98.9% Among whom,...
RAS mutations occur in a broad spectrum of human hematopoietic malignancies. Activating Ras blood cells leads to malignancies mice. In murine stem (HSCs), mutant N-RasG12D activates Stat5 dysregulate cell function. However, the underlying mechanism remains elusive. this study, we demonstrate that activation induced by hyperactive Nras mutant, G12D, is dependent on Jak2 activity. activated HSCs and progenitors (HSPCs), inhibiting with ruxolitinib significantly decreases HSPC...
Abstract Graft-versus-host disease (GVHD) is the most serious complication of allogeneic hematopoietic cell transplantation. Notch signals delivered during first 48 h after transplantation drive proinflammatory cytokine production in conventional T cells (Tconv) and inhibit expansion regulatory (Tregs). Short-term inhibition induces long-term GVHD protection. However, it remains unknown whether blockade blunts through its effects on Tconv, Tregs, or both what early Notch-regulated molecular...
<sec> <b>What is already known on this topic?</b> </sec><sec> The national program of prevention mother-to-child transmission (PMTCT) syphilis was initiated in 2011 and scaled to a level since 2015. A better understanding the implementation outcomes PMTCT needed for future strategies achieve World Health Organization (WHO) goal elimination (EMTCT) syphilis. added by report</b> Between 2018, as coverage screening pregnant women treatment syphilis-seropositive their infants have increased...
Bone morphogenetic proteins (BMPs), a subgroup of the TGF-β superfamily, play critical roles in neural progenitor cell fate determination. Neural stem cells (NSCs) are multipotent that can differentiate into neurons, oligodendrocytes and astrocytes under certain conditions. In our recent report, using an antibody recognize both BMP-2 BMP-4 (BMP-2/4), we showed BMP-2/4 is only expressed differentiated from NSCs medium containing 1% fetal bovine serum (FBS). this vitro model, astrocytic...