A5012984938- Cardiac Fibrosis and Remodeling
- Schizophrenia research and treatment
- Signaling Pathways in Disease
- Mental Health Treatment and Access
- Atrial Fibrillation Management and Outcomes
- Cardiac Ischemia and Reperfusion
- Child and Adolescent Psychosocial and Emotional Development
- Family Caregiving in Mental Illness
- Cardiac electrophysiology and arrhythmias
- Transcranial Magnetic Stimulation Studies
- Suicide and Self-Harm Studies
- Mental Health and Psychiatry
- Cardiomyopathy and Myosin Studies
- Antioxidant Activity and Oxidative Stress
- Coronary Interventions and Diagnostics
- Functional Brain Connectivity Studies
- Viral Infections and Immunology Research
- Cardiac Arrhythmias and Treatments
- Traumatic Brain Injury Research
- Cardiac Imaging and Diagnostics
- Estrogen and related hormone effects
- Glutathione Transferases and Polymorphisms
- Maternal and fetal healthcare
- Head and Neck Anomalies
- Nutritional Studies and Diet
Harbin Medical University
2019-2025
Daqing City People's Hospital
2019-2025
Shenzhen Bao'an District People's Hospital
2022-2025
Community Health Center
2024
University of Shanghai for Science and Technology
2024
First Affiliated Hospital of Henan University of Science and Technology
2024
Washington University in St. Louis
2018-2023
Qiqihar Medical University
2023
Zhengzhou University
2023
Jiangyin People's Hospital
2012-2023
Despite the long-standing recognition that immune response to acute myocardial injury contributes adverse left ventricular (LV) remodeling, it has not been possible effectively target this clinically. Using 2 different in vivo models of injury, we show pirfenidone confers beneficial effects murine heart through an unexpected mechanism depends on cardiac B lymphocytes. Naive hearts contained a large population CD19+CD11b-CD23-CD21-IgD+IgMlo lymphocytes, and smaller populations CD19+CD11b+ B1a...
CD147, also known as EMMPRIN or basigin, is a transmembrane glycoprotein receptor that activates matrix metalloproteinases and promotes inflammation. CD147 function regulated by posttranslational modifications of which glycosylation has attracted the most attention. In this study, we demonstrated glycosylated was dominant form in heart tissue, its levels were markedly elevated response to transverse aortic constriction (TAC). Adeno-associated virus 9-mediated, cardiac-specific overexpression...
Exercise training has been demonstrated as an effective therapy for insulin resistance (IR) to relieve skeletal muscle metabolic disorders. Physiologic protective autophagy was found blocked by IR induced severe endoplasmic reticulum (ER) stress, which may lead progression of IR. However, the mechanisms are not fully understood. Therefore, this study sought investigate that how exercise act on through exploration into mechanism ER stress and high-fat diet (HFD)-blocked autophagy. A rodent...
This study introduces an interpretable imbalanced data classification method for detecting cryptocurrency transaction fraud. We address imbalance using SMOTE oversampling and augmentation through contrastive learning. Next, we introduce a Transformer-based deep learning model that learns sample relevance. The undergoes pre-training with loss fine-tuning Bayesian optimization to effectively extract high-dimensional, higher-order, fraud-related features. employ SHAP-based interpreter along...
<title>Abstract</title> <bold>Background</bold> Identifying predictors of developmental outcomes in non-suicidal self-injury (NSSI) is crucial and goes beyond tracking its progression. EEG technology notable for consistent objective neurophysiological recordings NSSI detection. Using ERP components deep learning models predicting these still underexplored. <bold>Methods</bold> Twenty-six the remission group (RG), twenty-nine aggravation (AG), twenty-seven healthy (HG) completed affective...
ABSTRACT Committing a family member with schizophrenia to psychiatric ward is coping mechanism often employed under challenging circumstances. This decision entails significant emotional repercussions and ethical dilemmas, potentially undermining the psychological well‐being of eroding public trust in mental health services professionals. study investigates experiences regret among members after deciding commit relative locked ward, adhering COREQ guidelines. Employing descriptive...
Non-suicidal self-injury (NSSI) poses a significant public health concern, characterized by its high prevalence, recurrence, and association with suicide. While prior research has identified connection between negative life events (NLEs) NSSI, only few studies have longitudinally explored this relation underlying mechanisms. Our study investigated the longitudinal NLEs NSSI among Chinese college students. We also examined mediating role of rumination emotional regulation difficulties, as...
Abstract Direct seawater electrolysis at ampere-level current densities, powered by coastal/offshore renewables, is an attractive avenue for sustainable hydrogen production but undermined chloride-induced anode degradation. Here we demonstrate the use of hexafluorophosphate (PF₆⁻) as electrolyte additive to overcome this limitation, achieving prolonged operation over 5,000 hours 1 A cm −2 and 2300 2 using NiFe layered double hydroxide (LDH) anode. Together with experimental findings, PF₆⁻...
BACKGROUND:Chinese hawthorn (Crataegus pinnatifida) fruit is a traditional Chinese medicine for treatment of digestive system and cardiovascular diseases. The contains polyphenol compounds, such as epicatechin, that have anti-inflammatory activity. This study aimed to investigate the effects an alcohol extract (HAE) on inflammation oxidative stress in rats with doxorubicin-induced chronic heart failure (CHF). MATERIAL AND METHODS:Rats were intraperitoneally injected doxorubicin induce CHF...
To evaluate the efficacy and safety of intracoronary administration prourokinase via balloon catheter during primary percutaneous coronary interventions in patients with acute ST-segment elevation myocardial infarction.Acute infarction underwent were randomly divided into two groups: group (n = 125) control 135). During interventions, or saline was injected to distal end culprit lesion after dilatation. Demographic clinical characteristics, infarct size, reperfusion, cardiac functions...
Oxidized low density lipoprotein (ox-LDL) and its receptor, lectin-Like ox-LDL receptor-1 (LOX-1), play important roles in the development of endothelial injuries. Olmesartan can protect cells from impairment caused by various pathological stimulations. In present study we investigated whether olmesartan decreased induced exerting effects on LOX-1 both vitro vivo. Incubation cultured neonatal rats with for 24 h or infusion mice 3 weeks led to remarkable cells, including increased lactate...
To explore the role of HOTAIR in pathogenesis adrenocortical carcinoma (ACC) and its underlying mechanism.Differentially expressed lncRNA (HOTAIR) ACC was screened out from GEO database. The survival analysis ROC curve were performed according to expressions patients. correlation between expression clinical information patients analyzed by chi-square test. univariate multivariate COX regression carried analyze relationship expression, disease-free (DFS) overall (OS) We then detected 77...
Myocardial ischemia reperfusion (MIR) injury negatively affects the prognosis of acute myocardial infarction (AMI), while effective suppression MIR remains a largely unmet clinical need. Interferon regulatory factors (IRF) are key players in chronic cardiac disorders such as remodeling. However, their roles remain unknown. In current study, microarray data indicated that IRF1 expression was consistently changed human ischemic heart and reperfused mouse heart. Western blot analysis confirmed...
BACKGROUND Patients rarely develop complicated infections in thyroid cysts. Here, we describe a patient with chronic infected unilateral giant cyst related to diabetes mellitus (DM). CASE SUMMARY A 66-year-old male was admitted due an evident neck lump for 5 d after approximately 40 years of gradually progressive mass and 7 DM. Doppler ultrasound computed tomography scan showed the left gland lobe. He diagnosed large nodule by tracheal dislocation had surgical indications. Surgical...
Older adults diagnosed with schizophrenia face unique public health challenges, specific treatment needs, complex care demands, accelerated aging, and increased susceptibility to issues. This phenomenological study explored the existential realities needs of older schizophrenia. Fifteen participants, a mean age 69.47 (SD ± 9.47) years, ranging from 62 79 years old hailing rural regions, participated in study. Four main themes eight sub-themes emerge: compounding burden (challenges symptom...