A5054593497- Gold and Silver Nanoparticles Synthesis and Applications
- Photoreceptor and optogenetics research
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Microbial Inactivation Methods
- Microfluidic and Bio-sensing Technologies
- Laser-Ablation Synthesis of Nanoparticles
- Thermochemical Biomass Conversion Processes
- SARS-CoV-2 detection and testing
- nanoparticles nucleation surface interactions
- Photochromic and Fluorescence Chemistry
- Carbon Dioxide Capture Technologies
- Barrier Structure and Function Studies
- Advanced Thermodynamics and Statistical Mechanics
- Molecular Communication and Nanonetworks
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Extracellular vesicles in disease
- Spectroscopy Techniques in Biomedical and Chemical Research
- Neuroscience and Neural Engineering
- Bacteriophages and microbial interactions
- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
The University of Texas at Dallas
2017-2025
The University of Texas Southwestern Medical Center
2008-2025
Southwestern Medical Center
2008-2025
Sun Yat-sen University
2025
Nanning Normal University
2023-2024
Changzhi Medical College
2024
Northeastern University
2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Henan Provincial Center for Disease Control and Prevention
2023
Abstract Cryptococcal meningitis is common in sub-Saharan Africa. Given the need for data a rapid, point-of-care cryptococcal antigen (CRAG) lateral flow immunochromatographic assay (LFA), we assessed diagnostic performance of cerebrospinal fluid (CSF) culture, CRAG latex agglutination, India ink microscopy, and LFA 832 HIV-infected persons with suspected during 2006–2009 (n = 299) Uganda 2010–2012 533) South had best (sensitivity 99.3%, specificity 99.1%). Culture sensitivity was dependent...
Heat beyond visual: The thermal contrast from the heating of gold nanoparticles upon laser stimulation can improve analytical sensitivity lateral flow assays (LFAs; see picture). A 32-fold improvement in an approved LFA for cryptococcal antigen (purple diamond) was shown, with potential further by optimizing backing material and properties antibody-coated (red circle blue Y).
Abstract Gold nanoparticles (GNPs) are widely used for biomedical applications due to unique optical properties, established synthesis methods, and biological compatibility. Despite important of plasmonic heating in thermal therapy, imaging, diagnostics, the lack quantification heat generation leads difficulties comparing capability new nanostructures predicting therapeutic diagnostic outcome. This study quantifies GNP by experimental measurements theoretical predictions gold nanospheres...
Zebrafish embryos can attain a stable cryogenic state by microinjection of cryoprotectants followed rapid cooling, but the massive size embryo has consistently led to failure during convective warming process. Here we address this zebrafish cryopreservation problem using gold nanorods (GNRs) assist in Specifically, microinjected cryoprotectant propylene glycol into along with GNRs, and samples were cooled at rate 90 000 °C/min liquid nitrogen. We demonstrated ability unfreeze rapidly (1.4 ×...
Carbon dioxide is the major greenhouse gas that contributes to global warming more than 60%. from power plants one of main sources. Therefore it essential reduce CO2 emission plant flue gas. Post- combustion carbon capture optimal choice in near-to meddle-term, since does not need change configuration essentially. Chemical absorption with amine-based solvents currently state-of-the-art technology for post- capture. This paper introduces typical amine process and analyses problems during...
There is an increasing need for highly sensitive and quantitative diagnostics at the point-of-care. The lateral flow immunoassay (LFA) one of most widely used point-of-care diagnostic tests; however, LFAs generally suffer from low sensitivity lack quantification. To overcome these limitations, thermal contrast amplification (TCA) a new method that based on laser excitation gold nanoparticles (GNPs), commonly visual signature, to evoke signature. facilitate clinical translation TCA...
The blood–brain barrier (BBB) is highly selective and acts as the interface between central nervous system circulation. While BBB critical for maintaining brain homeostasis, it represents a formidable challenge drug delivery. Here we synthesized gold nanoparticles (AuNPs) targeting tight junction specifically demonstrated that transcranial picosecond laser stimulation of these AuNPs post intravenous injection increases permeability. permeability change can be graded by intensity, entirely...
Abstract The treatment of glioblastoma has limited clinical progress over the past decade, partly due to lack effective drug delivery strategies across blood-brain-tumor barrier. Moreover, discrepancies between preclinical and outcomes demand a reliable translational platform that can precisely recapitulate characteristics human glioblastoma. Here we analyze intratumoral barrier heterogeneity in characterize two genetically engineered models female mice important glioma phenotypes, including...
Thermodynamic metastable nanomaterials display attractive properties due to their unique atom configuration and microstructure, distinct from counterparts found in equilibrium phase diagrams. However, fabrication remains a grand challenge because conventional methods are generally operated under near-equilibrium conditions. To break the thermodynamic limits for discovering novel materials, numerous by adopting extreme strategies have been developed, including ultrafast synthesis, Joule...
With the recent advance in micro/nano-fabrication technology, micro Coulter counters have been widely used detecting and characterizing micro- nanoscale objects. In this paper, electrical resistance change during translocation of a non-conducting particle through channel is studied numerically. The numerical results are validated by proven analytical available literature. effects particle's off-axis position, shape orientation, entry position for particles with large dynamic range. From...
The ability to detect pathogens specifically and sensitively is critical combat infectious diseases outbreaks pandemics. Colorimetric assays involving loop-mediated isothermal amplification (LAMP) provide simple readouts yet suffer from the intrinsic non-template amplification. Herein, a highly specific sensitive assay relying on plasmonic sensing of LAMP amplicons via DNA hybridization, termed as LAMP, developed for severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) RNA...
Abstract Rapid and sensitive diagnostics of infectious diseases is an urgent unmet need as evidenced by the COVID-19 pandemic. Here, we report a strategy, based on DIgitAl plasMONic nanobubble Detection (DIAMOND), to address this need. Plasmonic nanobubbles are transient vapor bubbles generated laser heating plasmonic nanoparticles (NPs) allow single-NP detection. Using gold NPs labels optofluidic setup, demonstrate that DIAMOND achieves compartment-free digital counting works homogeneous...
Abstract Optical tweezers have profound importance across fields ranging from manufacturing to biotechnology. However, the requirement of refractive index contrast and high laser power results in potential photon thermal damage trapped objects, such as nanoparticles biological cells. Optothermal been developed trap particles cells via opto-thermophoresis with much lower powers. intense heating stringent solution environment prevent their use for general applications. Here, we propose...
Picosecond laser excitation of vascular-targeted gold nanoparticles activates multiple mechanobiological pathways in the endothelial cells and induces reversible blood–brain barrier opening.
Abstract Remote and minimally‐invasive modulation of biological systems with light has transformed modern biology neuroscience. However, absorption scattering significantly prevents penetration to deep brain regions. Herein, we describe the use gold‐coated mechanoresponsive nanovesicles, which consist liposomes made from artificial phospholipid Rad‐PC‐Rad as a tool for delivery bioactive molecules into tissue. Near‐infrared picosecond laser pulses activated gold‐coating on surface creating...
Abstract Ischemic stroke is a leading cause of death and disability remains without effective treatment options. Improved requires efficient delivery multimodal therapy to ischemic brain tissue with high specificity. Here, this article reports the development multifunctional polymeric nanoparticles (NPs) for both drug delivery. The NPs are synthesized using an reactive oxygen species (ROS)‐reactive poly (2,2′‐thiodiethylene 3,3′‐thiodipropionate) (PTT) polymer engineered penetration through...