A5085144196- Mental Health Treatment and Access
- MicroRNA in disease regulation
- Endoplasmic Reticulum Stress and Disease
- Melanoma and MAPK Pathways
- Family Caregiving in Mental Illness
- Circular RNAs in diseases
- Schizophrenia research and treatment
- Coronary Interventions and Diagnostics
- Resilience and Mental Health
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Viral Infectious Diseases and Gene Expression in Insects
- Tryptophan and brain disorders
- Child and Adolescent Psychosocial and Emotional Development
- Cancer-related molecular mechanisms research
- Electrospun Nanofibers in Biomedical Applications
- Energy, Environment, and Transportation Policies
- Signaling Pathways in Disease
- Energy, Environment, Economic Growth
- Synthesis of Tetrazole Derivatives
- Chromatin Remodeling and Cancer
- Protein Kinase Regulation and GTPase Signaling
- Optimism, Hope, and Well-being
- Liver physiology and pathology
- Proteoglycans and glycosaminoglycans research
Harbin Medical University
2019-2025
Johns Hopkins University
2024
Bloomberg (United States)
2024
Sidney Kimmel Comprehensive Cancer Center
2024
Daqing City People's Hospital
2019-2024
Roswell Park Comprehensive Cancer Center
2024
Dalian Medical University
2024
Keio University
2024
Columbia University Irving Medical Center
2024
National Health Research Institutes
2024
Amyloid beta-peptide (Abeta) plaques, one of the major neuropathological lesions in Alzheimer's disease (AD), can be broadly subdivided into two morphological categories: neuritic and diffuse. Heparan sulfate (HS) HS proteoglycans (HSPGs) are codeposits multiple amyloidoses, including AD. Although has been considered a limiting factor initiation amyloid deposition, pathological implications Abeta deposits AD remain unclear. In this study, immunohistochemistry combined with fluorescence...
ABSTRACT Committing a family member with schizophrenia to psychiatric ward is coping mechanism often employed under challenging circumstances. This decision entails significant emotional repercussions and ethical dilemmas, potentially undermining the psychological well‐being of eroding public trust in mental health services professionals. study investigates experiences regret among members after deciding commit relative locked ward, adhering COREQ guidelines. Employing descriptive...
<italic>Caspase3</italic> gene silencing based on the transfer carrier F-CNT-siCas3 had obvious protective effects myocardial cell apoptosis, ventricular remodeling, and cardiac function in Sprague-Dawley (SD) rats after coronary artery ligation.
MicroRNA-24 (miR-24) is an apoptosis suppressor miRNA downregulated in cardiomyocytes after acute myocardial infarction (AMI). However, due to the lack of effective delivery strategies, role anti-apoptotic miR-24 post-acute remains unexplored. Here, we used a silica nanoparticle-based polyelectrolyte (polyethylenimine, PEI) system study miR-24. These particles with good biocompatibility could be efficiently internalized into cells and release loaded cytoplasm. As result, overexpression...
This paper proposes a dynamic industrial transfer index for the first time to characterize spatial matchability of factor mobility and transfer, then explores correlation between mobility, carbon emission intensity by using panel data from 30 provinces in China during 2004–2019. The results show that China’s ability reduce emissions is improving, has dropped 44.84%. In addition, there an obvious mismatch transfer. Specifically, production factors generally flow high-carbon areas low-carbon...
Abstract This study aims to test the moderation and mediation effects of self-acceptance self-reported health on self-worth's impact subjective well-being among elderly Chinese rural empty-nester elderly, confirm whether self-report is a moderating variable between self-worth well-being. cross-sectional was performed from May 2017 April 2018; participants were 365 empty-nest adults areas Chifeng City in Inner Mongolia. Data collected with General information questionnaire, Self-worth...
This study aimed to investigate the factors associated with suicidal ideation in schizophrenia patients China using decision tree and logistic regression models. From October 2020 March 2022, were chosen from Chifeng Anding Hospital Daqing Third Heilongjiang Province. A total of 300 who met inclusion criteria investigated by questionnaire. The questionnaire covered general data, ideation, childhood trauma, social support, depressive symptoms psychological resilience. Logistic analysis...
Abstract Background Discs large homolog 5 (Dlg5) is a member of the membrane-associated guanylate kinase (MAGUK) adaptor family proteins and its deregulation has been implicated in malignancy several cancer types. Dlg5 was down-regulated hepatocellular carcinoma (HCC) lower expression associated with poor survival HCC patients. However, how to regulate remains largely unknown. Methods The co-immunoprecipitation assay used determine interaction between β-TrCP. vivo ubiquitination performed...
MicroRNAs (miRNAs) are a category of small RNAs that constitute new layer complexity to gene regulation within the cell, which has provided perspectives in understanding cancer biology. The deregulation miRNAs contributes critically development and pathophysiology number cancers. have been found participate cell transformation multiplication by acting as tumour oncogenes or suppressors; therefore, harnessing may provide promising therapeutics. Another major function is their activity...
A 67-year-old man had a sev-ere cough and pulmonary infection for 1 wk before seeking evaluation at our hospital.He undergone esophagectomy with gastric pull-up radiotherapy esophageal cancer 3 years previously.After admission to hospital, gastroscopy bronchoscopy revealed fistulous communication between the posterior tracheal wall near carina upper residual stomach.We measured diameter of trachea bronchus determined site size fistula using multislice computed tomography gastroscopy.A...
The adaptive T cell response is accompanied by continuous rewiring of the cell's electric and metabolic state. Ion channels nutrient transporters integrate bioelectric biochemical signals from environment, setting cellular states. Divergent states contribute to immunity or tolerance. Here, we report that neuritin (Nrn1) contributes tolerance development modulating regulatory effector function. Nrn1 expression in cells promotes its expansion suppression function, while dampens inflammatory...
ABSTRACT Objective To identify the determinants of family resilience in recovery individuals with schizophrenia using Walsh's framework. Design A cross‐sectional study. Methods In Northeast China, 403 patients diagnosed were enrolled for this study, assessing resilience, communication, social support, illness knowledge, hope and functioning. Regression analyses conducted SPSS 27.0, mediation effects examined Mplus 7.0. Results Logistic regression showed that female gender having a sibling as...
Acute lung injury (ALI) is characterized by neutrophilic infiltration, uncontrolled oxidative stress and inflammatory processes. Despite various therapeutic regimes having been performed, there remains no effective pharmacotherapy available to treat ALI. Halofuginone (HF), a ketone isolated from Dichroa febrifuga, exhibits significant anti‑inflammatory antifibrotic effects. Dexamethasone (DEX), synthetic glucocorticoid, has routinely used as an adjuvant therapy in treating diseases,...
Abstract Background Among all types of mental disorders, individuals with schizophrenia exhibit the highest frequency aggressive behavior. This disrupts healthcare environment and poses threats to family life social harmony. Present approaches fail identify who are predisposed In this study, we aimed construct a risk prediction model for behavior in stable patients schizophrenia, which may facilitate early identification aggression by assessing relevant factors, enabling management high-risk...
This study aims to verify the mediating role of resilience between self-esteem and mental disability analyze moderating gender in relationship patients with schizophrenia. Patients schizophrenia have been selected from Harbin Psychiatric (Baiyupao) Hospital Daqing Third Heilongjiang Province January December 2021. The recruited a total 220 schizophrenia, including 120 males 100 females measure their self-esteem, disability. results were as follows: Self-esteem are important protective...
The adaptive T cell response is accompanied by continuous rewiring of the cell’s electric and metabolic state. Ion channels nutrient transporters integrate bioelectric biochemical signals from environment, setting cellular states. Divergent states contribute to immunity or tolerance. Here, we report that neuritin (Nrn1) contributes tolerance development modulating regulatory effector function. Nrn1 expression in cells promotes its expansion suppression function, while dampens inflammatory...
Abstract Background To evaluate the effect of stent boost subtract (SBS) imaging on underexpansion during percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI) by optical coherence tomography (OCT). Methods One hundred thirty-eight STEMI who underwent drug-eluting (DES) implantation were prospectively recruited and divided into SBS group (69 cases) CAG according to whether was used guide PCI. Finally, OCT performed all enrolled...