A5000920320- Tea Polyphenols and Effects
- Fatty Acid Research and Health
- Gut microbiota and health
- Heavy Metals in Plants
- Food Quality and Safety Studies
- Tannin, Tannase and Anticancer Activities
- Cancer, Lipids, and Metabolism
- Phytochemicals and Antioxidant Activities
- Advanced Nanomaterials in Catalysis
- Analytical chemistry methods development
- Natural product bioactivities and synthesis
- Advanced Glycation End Products research
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Antioxidant Activity and Oxidative Stress
- Metabolomics and Mass Spectrometry Studies
- Liver Disease Diagnosis and Treatment
- Aerodynamics and Fluid Dynamics Research
- Traditional Chinese Medicine Analysis
- Free Radicals and Antioxidants
- Peroxisome Proliferator-Activated Receptors
- Inflammatory mediators and NSAID effects
- Heavy Metal Exposure and Toxicity
- Aluminum toxicity and tolerance in plants and animals
- Phytochemistry and Biological Activities
Zhejiang University
2013-2025
University of Science and Technology Beijing
2023
Second Affiliated Hospital of Zhejiang University
2013
Zhejiang University of Technology
2006-2012
Jiaxing University
2011
Tea Research Institute
2005
Center for Food Safety and Applied Nutrition
2004
United States Food and Drug Administration
2004
Institute of Biophysics
2001
Academia Sinica
1999
Some polyunsaturated fatty acids (PUFAs), if not all, have been shown to tumoricidal action, but their exact mechanism(s) of action is clear. In the present study, we observed that n-6 PUFA linoleic acid (LA) inhibited tumor cell growth at high concentrations (above 300 μM); while low (100-200 μM) promoted proliferation. Analysis mitochondrial membrane potential, reactive oxygen species (ROS) formation, malondialdehyde (MDA) accumulation and superoxide dismutase (SOD) activity suggested...
Inflammation is associated with promotion of the initiation various malignancies, partly due to bacterial infection-induced microenvironmental changes. However, exact association between microbiota in urine, seminal fluid and expressed prostatic secretions benign hypertrophy prostate cancer not clear.In present study, we investigated type (EPS) patients hyperplasia (BPH) by polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) method using universal primers. In order...
Colorectal cancer is common in developed countries. Polyunsaturated fatty acids (PUFAs) have been reported to possess tumoricidal action, but the exact mechanism of their action not clear.In present study, we studied effect various n-6 and n-3 on survival colon cells LoVo RKO evaluated possible involvement a mitochondrial pathway ability induce apoptosis.It was observed that α-linolenic acid, eicosapentaenoic acid docosahexaenoic (ALA, EPA DHA respectively) linoleic gamma-linolenic...
Gastric cancer (GC) is one of the common malignant tumors in China, with a high morbidity and mortality. With development application high-throughput sequencing technologies metagenomics, great quantity studies have shown that gastrointestinal microbiota closely related to digestive system diseases. Although some reported effect long-term follow-up after subtotal gastrectomy on intestinal flora changes patients GC. However, features gut their shifts GC perioperative period remain...
Abstract Polyunsaturated fatty acids (PUFAs) have tumoricidal action, though the exact mechanism of their action is not clear. The results present study showed that all tested, linoleic acid (LA) and α-linolenic (ALA) were most effective in suppressing growth normal gastric cells (GES1) at 180 200 μM, while carcinoma (MGC SGC) inhibited μM. Arachidonic (AA) suppressed GES1, MGC SGC lower concentrations (120 160 μM) AA more against compared to (GES1). Paradoxically, both eicosapentaenoic...
Abstract Prostate cancer (PCa) is one of the leading causes death in elderly men. Polyunsaturated fatty acids (PUFAs) regulate proliferation cells. In present study, we evaluated effect various PUFAs on and survival human prostate (PC-3) epithelial (RWPE-1) cells vitro. LA, GLA, AA, ALA, EPA DHA (linoleic acid, gamma-linolenic arachidonic alpha-linolenic eicosapentaenoic acid docosahexaenoic respectively) when tested at 50, 100, 150, 200 μM inhibited RWPE-1 PC-3 cells, except that lower...
Prostate cancer (PCa), the most common malignancy in men, is a major cause of deaths. A better understanding mechanisms that drive tumor initiation and progression may identify actionable targets to improve treatment this patient group. As dietary carotenoid, astaxanthin has been demonstrated exert beneficial effects against inflammation, cardiovascular disease, oxidative damage, or different sites. This study used intragastric administration detect its role on proliferation, apoptosis,...
Background Colorectal cancer is common. Polyunsaturated fatty acids (PUFAs) exert growth-inhibitory and pro-apoptotic effects on colon cells. Metabolites of PUFAs such as prostaglandins (PGs), leukotrienes (LTs) lipoxins (LXs) play a significant role in cancer. Methods Human LoVo RKO cells were cultured with different concentration 5-fluorouracil (5-FU) vitro. Cell morphological changes, acid composition, formation PGE2, LTB4 LXA4 expression COX-2, ALOX5, PGD synthase (PGDS), microsomal...
Following the publication of this paper, it was drawn to Editor's attention by a concerned reader that, for flow cytometric plots shown in Fig. 9A on p. 1628, pair data panels showed surprisingly high level partially overlapping data, given that results from differently performed experiments were intended have been these figure parts. Upon performing an independent analysis series further issues concerning noted; first 9B, separate appeared duplicated their entireties. In addition, two pairs...
Depression is a widely prevalent mental disorder, and nutritional interventions play an increasingly important role in its treatment. In this paper, effects of linoleic acid (LA) on depressive behavior mice induced by gut microbiome disorders were investigated.
Metabolic syndrome (MetS) is associated with carotid intima-media thickness (CIMT), which a good predictor of cardiovascular disease (CVD). However, among individuals MetS, direct comparative data regarding the utility apoB/apoAΙ ratio and non-HDL-C/HDL-C to diagnose atherosclerosis are scarce, particularly in Chinese populations. We aimed determine relationship between MetS.
Short-chain fatty acids (SCFA) such as acetic acid, propionic and butyric acid are produced by fermentation gut microbiota. In this paper, we investigate the effects of SCFA on 3T3-L1 cells underlying molecular mechanisms. The were treated with or when induced to differentiate into adipocytes. MTT assay was employed detect viability cells. Oil Red O staining used visualize lipid content in A triglyceride kit triacylglycerol qRT-PCR Western blot evaluate expression metabolic enzymes. results...
Green tea is an effective chemopreventive agent to human prostate cancer adenoma (PCA). Epigallocatechin gallate (EGCG) inhibited the growth of PCA cells and induced apoptosis. Cu2+ a trace element necessary our health. Many studies proved that bioactivity EGCG altered in presence Cu2+. We investigated effects on Also, we explored potential mechanisms via measurement relative chemiluminescence medium for cells. Chemiluminscence can be indication free radicals. Our test results showed...
Five catechins [(-)-epigallocatechins gallate (EGCG), (-)-epicatechin (ECG), (-)-epigallocatechin (EGC), (EC), and (+)-catechin (C)] were compared with regard to their effects on 6-hydroxydopamine (OHDA)-induced apoptosis in PC12 cells--the vitro model of Parkinson's disease. Measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, 6-OHDA inhibited cell viability a time- concentration-dependent manner. When cells pretreated the five for 30 min before exposure 250...