A5069131432- Advanced Neuroimaging Techniques and Applications
- Photonic and Optical Devices
- Advanced MRI Techniques and Applications
- Free Radicals and Antioxidants
- Antioxidant Activity and Oxidative Stress
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Nanoparticle-Based Drug Delivery
- Medical Imaging Techniques and Applications
- Intestinal Malrotation and Obstruction Disorders
- Cancer Immunotherapy and Biomarkers
- Advanced Fiber Optic Sensors
- Plasmonic and Surface Plasmon Research
- Pancreatic and Hepatic Oncology Research
- Multilevel Inverters and Converters
- Nanowire Synthesis and Applications
- Advanced DC-DC Converters
- Obesity, Physical Activity, Diet
- Phytochemistry and biological activity of medicinal plants
- Phytochemicals and Antioxidant Activities
- Traditional Chinese Medicine Analysis
- Gut microbiota and health
- Fetal and Pediatric Neurological Disorders
- Innovation Policy and R&D
- Chemical Safety and Risk Management
Huazhong University of Science and Technology
2025
Tongji Hospital
2025
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Shenzhen Institutes of Advanced Technology
2021-2024
Hubei University of Technology
2024
Chinese Academy of Sciences
2008-2024
Zhejiang University
2011-2022
Ningbo University
2021-2022
Peng Cheng Laboratory
2021
Abstract Background Accumulating evidence suggests that the gut microbiota and metabolites can modulate tumor responses to immunotherapy; however, limited data has been reported on biliary tract cancer (BTC). This study used metagenomics metabolomics identify characteristics of microbiome in immunotherapy-treated BTC their potential as prognostic predictive biomarkers. Methods prospective cohort enrolled 88 patients with who received PD-1/PD-L1 inhibitors from November 2018 May 2022. The...
Near-infrared light-sensitive polymeric micelles were prepared for the enhanced intracellular delivery of doxorubicin (DOX). The from dextran-graft-(2-diazo-1,2-naphthoquinone) (Dex-DNQ) amphiphilic copolymers which synthesized by modification hydrophilic dextran with hydrophobic DNQ molecules. molecule is an attractive photo-trigger group because its UV/NIR-induced Wolff rearrangement can result in a drastic change into 3-indenecarboxylic acid (3-IC) pKa 4.5. Thus, under UV or NIR...
Objectives: To evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) started with citalopram in first-episode young major depressive patients. Methods: In a 2-week double-blind study extended antidepressant phase, 60 patients were randomly assigned to combination 2 weeks either active or sham rTMS treatment. During following weeks, continued only The 17-item Hamilton depression rating scale (HAMD-17) and Montgomery–Asberg (MADRS) used assess severity depression....
Background The association between gut bacteria and the response to immune checkpoint inhibitors (ICI) in hepatocellular carcinoma (HCC) has been studied; however, multi-kingdom microbiome alterations interactions ICI-treated HCC cohorts are not fully understood. Methods From November 2018 April 2022, patients receiving ICI treatment for advanced were prospectively enrolled. Herein, we investigated microbiota characterization of microbiome, mycobiome, metabolome using metagenomic, ITS2,...
We demonstrate a compact hybrid structure red-green-ultraviolet three-color laser consisting of three distinct semiconductor nanowires (CdSe, CdS and ZnO) attached to silica microfiber, which is pumped by 355 nm wavelength pulses. The exciting the collection photoluminescence (PL) are implemented means evanescent coupling through same microfiber. When pump energy higher than 1.3 microJ, spatially spectrally lasing groups can be measured at output port simultaneously. approach extended other...
Prostate cancer (PCa), the most common malignancy in men, is a major cause of deaths. A better understanding mechanisms that drive tumor initiation and progression may identify actionable targets to improve treatment this patient group. As dietary carotenoid, astaxanthin has been demonstrated exert beneficial effects against inflammation, cardiovascular disease, oxidative damage, or different sites. This study used intragastric administration detect its role on proliferation, apoptosis,...
In this study, formulation of soy protein- and gluten-based gel materials for 3D printing in a model study has been successfully developed employing thermosensitive cocoa butter to investigate its feasibility preparing meat analogues. The influence protein, starch, sodium alginate on extrusion formability accuracy was investigated. doughs protein isolate notably better than that pea protein. Addition appropriate amounts butter, Tween-80, essential achieve superior performance....
Bending losses of nanofibers or nanowires with circular 90 degrees bends are simulated using a three-dimensional finite-difference time-domain (3D-FDTD) method. Dependences bending on wavelength and polarization guided light investigated, as well the diameters, refractive indices, radii nanowires. The acceptable (approximately 1 dB/90 degrees) predicted in glass, polymer, semiconductor down to micrometer level may offer valuable references for assembling highly compact photonic integrated...
For polymersomes to achieve their potential as effective delivery vehicles, they must efficiently encapsulate therapeutic agents into either the aqueous interior or hydrophobic membrane. In this study, cell membrane-mimetic were prepared from amphiphilic poly(d,l-lactide)-b-poly(2-methacryloyloxyethylphosphorylcholine) (PLA-b-PMPC) diblock copolymers and used encapsulation devices for water-soluble molecules. Thioalkylated zwitterionic phosphorylcholine protected quantum dots (PC@QDs) chosen...
In this study, incorporation of gallic acid into typical phytosterols (β-sitosterol and stigmasterol) through Steglich esterification was optimized employing the protection deprotection strategy. A novel mechanism leading to side discovered. Complication phenolic hydroxyl groups reactions were successfully reduced under conditions. The structural identity purity galloyl stigmasterol β-sitosterol confirmed by NMR, FT-IR, HPLC-MS. Evaluation revealed their excellent antioxidant...
Based on low-loss fusion splicing of microfibers using a <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$\hbox{CO}_{2}$</tex></formula> laser, we demonstrate free-standing microfiber closed-loop resonators. Loaded Notation="TeX">$Q$</tex></formula> -factors 110 500 with finesse 15.3 are obtained around 1.5- xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\mu{\hbox...
A botanical injection is a special drug preparation with extremely high safety requirements. Therefore, many separation technologies, such as ethanol precipitation and liquid–liquid extraction, are applied in the manufacturing process of injections to purify efficacy compounds remove impurities. In this work, second 1-butanol extraction were compared purification concentrated supernatant danshen (the dried root Salvia miltiorrhiza). These two technologies showed satisfactory recovery...