A5101763880- Analytical chemistry methods development
- Gut microbiota and health
- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Diet and metabolism studies
- Venomous Animal Envenomation and Studies
- Chemical Synthesis and Analysis
- Pesticide Residue Analysis and Safety
- Microfluidic and Capillary Electrophoresis Applications
- Food Quality and Safety Studies
- Peroxisome Proliferator-Activated Receptors
- Biochemical and Structural Characterization
- Child Nutrition and Water Access
- Enhanced Recovery After Surgery
- Simulation and Modeling Applications
- Biological Activity of Diterpenoids and Biflavonoids
- Urinary Tract Infections Management
- Nanoplatforms for cancer theranostics
- GABA and Rice Research
- Nicotinic Acetylcholine Receptors Study
- Pharmacological Effects and Assays
- Aldose Reductase and Taurine
- Synthesis of Organic Compounds
Zhejiang University of Technology
2012-2024
Weifang People's Hospital
2018-2024
Huaibei Normal University
2007-2012
Zhejiang University
2009
Some polyunsaturated fatty acids (PUFAs), if not all, have been shown to tumoricidal action, but their exact mechanism(s) of action is clear. In the present study, we observed that n-6 PUFA linoleic acid (LA) inhibited tumor cell growth at high concentrations (above 300 μM); while low (100-200 μM) promoted proliferation. Analysis mitochondrial membrane potential, reactive oxygen species (ROS) formation, malondialdehyde (MDA) accumulation and superoxide dismutase (SOD) activity suggested...
Centipedes are excellent predatory arthropods that inject venom to kill or immobilize their prey. Although centipedes have long been known be venomous, venoms remain largely unexplored. The chemical components responsible for centipede predation and the functional mechanisms unknown. Twenty-six neurotoxin-like peptides belonging ten groups were identified from venoms, Scolopendra subspinipes mutilans L. Koch by peptidomics combined with transcriptome analysis, revealing diversity of...
Inflammation is associated with promotion of the initiation various malignancies, partly due to bacterial infection-induced microenvironmental changes. However, exact association between microbiota in urine, seminal fluid and expressed prostatic secretions benign hypertrophy prostate cancer not clear.In present study, we investigated type (EPS) patients hyperplasia (BPH) by polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) method using universal primers. In order...
Colorectal cancer is common in developed countries. Polyunsaturated fatty acids (PUFAs) have been reported to possess tumoricidal action, but the exact mechanism of their action not clear.In present study, we studied effect various n-6 and n-3 on survival colon cells LoVo RKO evaluated possible involvement a mitochondrial pathway ability induce apoptosis.It was observed that α-linolenic acid, eicosapentaenoic acid docosahexaenoic (ALA, EPA DHA respectively) linoleic gamma-linolenic...
The disulfide-bridged hendecapeptide (CWTKSIPPKPC) loop, derived from an amphibian skin peptide, is found to have strong trypsin inhibitory capability. This called the loop (TIL), appears be smallest serine protease inhibitor known. A series of synthetic peptides this also exhibits activity;some even exhibit both antimicrobial and activities. Antimicrobial are attractive candidates for producing novel antibiotics, but their sensitivity trypsin-like proteases appreciably limits application....
Prostate cancer (PCa), the most common malignancy in men, is a major cause of deaths. A better understanding mechanisms that drive tumor initiation and progression may identify actionable targets to improve treatment this patient group. As dietary carotenoid, astaxanthin has been demonstrated exert beneficial effects against inflammation, cardiovascular disease, oxidative damage, or different sites. This study used intragastric administration detect its role on proliferation, apoptosis,...
Background Colorectal cancer is common. Polyunsaturated fatty acids (PUFAs) exert growth-inhibitory and pro-apoptotic effects on colon cells. Metabolites of PUFAs such as prostaglandins (PGs), leukotrienes (LTs) lipoxins (LXs) play a significant role in cancer. Methods Human LoVo RKO cells were cultured with different concentration 5-fluorouracil (5-FU) vitro. Cell morphological changes, acid composition, formation PGE2, LTB4 LXA4 expression COX-2, ALOX5, PGD synthase (PGDS), microsomal...
Abstract A new polyprenylated xanthone (=9 H ‐xanthen‐9‐one) and a benzophenone, namely oblongifolixanthone ( 1 ) garciniagifolone 2 ), were isolated from the bark of Garcinia oblongifolia , together with five known compounds including four xanthones 3 – 5 7 benzophenone 6 . The structures established by detailed analysis their spectroscopic data, especially 1D‐ 2D‐NMR spectra HR‐ESI‐MS data. All these assayed for cytotoxic activities against three human tumor cell lines (HeLa, SGC7901,...
Abstract BACKGROUND Binary functional monomers, allyl‐ β ‐cyclodextrin (allyl‐ ‐CD) and methacrylic acid (MAA) or ‐CD acrylonitrile (AN), were exploited in a fabrication of molecularly imprinted polymers (MIPs) for selective recognition large enrichment pirimicarb from aqueous media. RESULTS Special attention was paid to the computational simulation imprinting molecular monomers. The morphological characteristics MIPs made MAA (M‐MAA) characterised by scanning electron microscopy. effect...
Abstract The aim of the study was to address causality links and identify specific features gut microbiota signatures contributing host lipids metabolism in presence or absence polyene phosphatidylcholine (PPC) administration, evaluate potential risk PPC consumption. About 20 C57BL/6J mice were randomly allocated into two groups, normal diet group (CK) administration (205.2 mg/kg). Compared with CK group, contents unsaturated fatty acids increased saturated decreased group. content free...
Synthesis of teicoplanin molecularly imprinted membranes and a novel enrichment method for rapid determination teicoplanin.
Environmental pollution is a current area of focus worldwide, particularly heavy metal pollution. Feasible prevention or therapeutic strategies are required. Exploration the correlation between ω-3 polyunsaturated fatty acids (ω-3 PUFAs) and intestinal epithelial cells injured by metals may be significance for health. In present study, effects PUFAs on rat crypt cell line (IEC-6) its mechanisms were determined according to evaluation viability expression levels reactive oxygen species (ROS),...
Hypoxia is related to the etiology of numerous pathological disease states, such as formation tumors or diverse retinopathies. Epigallocatechin-3-gallate (EGCG), a potent polyphenolic antioxidant and antiangiogenic compound found in green tea, has been shown suppress growth blood vessels necessary for induction However, only few studies have carried focusing on protective effects EGCG hypoxia-induced injury cultured endothelial cells. The present study investigated Na2S2O4-induced hypoxic...