A5100428078- Health disparities and outcomes
- Food Security and Health in Diverse Populations
- Lysosomal Storage Disorders Research
- Calcium signaling and nucleotide metabolism
- Artificial Intelligence in Healthcare
- Carbohydrate Chemistry and Synthesis
- Psychological Well-being and Life Satisfaction
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
- Acupuncture Treatment Research Studies
- Phagocytosis and Immune Regulation
- Biomedical Research and Pathophysiology
- Sleep and related disorders
- Magnolia and Illicium research
- Gut microbiota and health
- Public Health Policies and Education
- Exercise and Physiological Responses
- Optimism, Hope, and Well-being
- Global Public Health Policies and Epidemiology
- Cellular transport and secretion
- Migration, Health and Trauma
- Cardiovascular Health and Risk Factors
- Opioid Use Disorder Treatment
- Prenatal Substance Exposure Effects
- COVID-19 epidemiological studies
Drexel University
2022-2024
Hangzhou City University
2024
Guangzhou Medical University
2024
Jinan University
2023
University of Alabama at Birmingham
2022-2023
Inner Mongolia Agricultural University
2023
Shanghai University
2022
Beijing University of Technology
2021
Rutgers, The State University of New Jersey
2016-2020
Rutgers Sexual and Reproductive Health and Rights
2019
Unesterified cholesterol accumulation in the late endosomal/lysosomal (LE/LY) compartment is cellular hallmark of Niemann-Pick C (NPC) disease, caused by defects genes encoding NPC1 or NPC2. We previously reported dramatic stimulation NPC2 transport rates to and from model membranes LE/LY phospholipid lysobisphosphatidic acid (LBPA). It had been shown that enrichment NPC1-deficient cells with LBPA results clearance. Here we demonstrate human NPC2-deficient cells, either directly via its...
Objectives. To describe the creation of an interactive dashboard to advance understanding COVID-19 pandemic from equity and urban health perspective across 30 large US cities that are members Big Cities Health Coalition (BCHC). Methods. We leveraged Drexel‒BCHC partnership define objectives audience for developed framework conceptualize inequities social groups, neighborhoods, cities. compiled data on trends by race/ethnicity, neighborhood, city, along with neighborhood- city-level...
Objectives. To examine racial/ethnic disparities in COVID-19 outcomes between Hispanics and Whites across 27 US jurisdictions whose health departments are members of the Big Cities Health Coalition (BCHC). Methods. Using surveillance data from BCHC dashboard as mid-June 2021, we computed crude incidence, age-adjusted hospitalization mortality, full vaccination coverage rates for by city. We estimated relative absolute cumulatively 2020 2021 explored associations city-level social...
To improve the phenomenon of exercise-induced fatigue that often occurs during horse racing, we previously studied improvement in exercise tolerance by acupoint catgut embedding preconditioning an rat model. We found pretreatment effectively improved animal tolerance. Here, combining transcriptomics and metabolomics, aimed to explore underlying mechanisms this improvement. used blood biochemical detection combined with ELISA detect triglyceride (TG), total cholesterol (TC), lactate...
Short-chain fatty acids (SCFA) such as acetic acid, propionic and butyric acid are produced by fermentation gut microbiota. In this paper, we investigate the effects of SCFA on 3T3-L1 cells underlying molecular mechanisms. The were treated with or when induced to differentiate into adipocytes. MTT assay was employed detect viability cells. Oil Red O staining used visualize lipid content in A triglyceride kit triacylglycerol qRT-PCR Western blot evaluate expression metabolic enzymes. results...
Background: Life expectancy in the United States has declined since 2014 but characterization of disparities within and across metropolitan areas country is lacking. Methods: Using census tract-level life from 2010 to 2015 US Small-area Expectancy Estimates Project, we calculate 10 measures total income-based at birth, age 25, 65 377 statistical (MSAs) States. Results: We found wide heterogeneity birth MSAs regions: West show narrowest (absolute disparity: 8.7 years, relative 1.1), while...
Abstract In order to realize the automation, standardization, and informatization of clinical laboratory work, this research topic develops accomplishes a set information systems (LISs). According design methods software engineering, we first understand user’s demand current work situation establish system case model using Unified Modeling Language (UML) modeling technique. During period, explain key technology theories, network structure, security policy connection scheme with hospital...
Patients with chronic lymphocytic leukemia (CLL) have reduced seroconversion rates and lower binding antibody (Ab) neutralizing (NAb) titers than healthy individuals following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA vaccination. Here, we dissected vaccine-mediated humoral cellular responses to understand the mechanisms underlying CLL-induced immune dysfunction.
Abstract Knowledge about neighborhood characteristics that predict disease burden can be used to guide equity-based public health interventions or targeted social services. We a case-control design examine the association between area-level vulnerability and severe COVID-19 using electronic records (EHR) from regional information hub in greater Philadelphia region. Severe cases ( n = 15,464 unique patients) were defined as those with an inpatient admission diagnosis of 2020. Controls 78,600;...
Background The majority of elderly individuals prefer to spend their final days in the Intensive Care Unit (ICU). ICU nurses are key providers hospice care, and attitudes toward death influence quality end-of-life nursing. Positive psychology emphasizes promoting positive death. A sense meaning life resilience critical aspects psychology, which essential for shaping nurses’ Objective This study aims investigate whether a indirectly affects through mediation resilience. Method total 212 from...
The Social Vulnerability Index (SVI) was created by the Centers for Disease Control and Prevention Agency Toxic Substances Registry (CDC/ATSDR) as a tool to assess resilience of communities in preparation public health crisis (Flanagan et al., 2011).In event emergencies, with higher SVI are considered more vulnerable, i.e., likely suffer serious consequences such mortality/physical injuries, displacement economic loss.The Geospatial Research, Analysis, Services Program (GRASP) maintains...
Niemann Pick Type C (NPC) disease is a lysosomal storage disorder characterized by cholesterol accumulation in the late endosome/lysosome (LE/LY) caused genetic defects either NPC1 or NPC2 proteins. Wild type (WT) 16 kDa soluble protein that binds with 1:1 stoichiometry. We previously showed interacts directly membranes to transport cholesterol; structure‐function analysis has shown several regions of surface are involved transport, suggesting can not only interact various orientations, but...
Abstract Unesterified cholesterol accumulation in the late endosomal/lysosomal (LE/LY) compartment is cellular hallmark of Niemann-Pick C (NPC) disease, caused by defects genes encoding NPC1 or NPC2. We previously reported dramatic stimulation NPC2 transport rates LE/LY phospholipid lysobisphosphatidic acid (LBPA) and these studies sought to determine their functional relationship normal egress. Here we demonstrate that interacts directly with LBPA identify hydrophobic knob domain as site...
Objectives To describe the association between population size, growth and opioid overdose deaths—overall by type of opioid—in US commuting zones (CZs) in three periods 2005 2017. Settings 741 CZs covering entirety are aggregations counties based on patterns that reflect local economies. Participants We used mortality data at county level from to 2017 National Center for Health Statistics. Outcome Opioid deaths were defined using underlying contributory causes death codes International...
Cardiovascular disease is the number one killer threatening human life and health. Globally, about 40% of deaths are caused by cardiovascular disease. This paper builds a model based on logistic regression method similarity evaluation distance formula to predict The data in this article comes from kaggle platform. In experiment, we used algorithm build first-stage model. accuracy recall rate reached 88.5% 89.2%. Then using Euclidean distance, optimize that cannot be processed first stage....
In order to improve the response time performance (RTP) of rapid process in acute care delivery, an analytical model and system-theoretic method are introduced study performance. The is used systematically describe process, decomposition assumption that each step approximate gamma distribution evaluate (RTP). results show compared with previous studies, this can more quickly accurately, then emergency efficiency medical staffs safety patients delivery. addition, we system characteristics...
Chronic lymphocytic leukemia (CLL) patients have lower seroconversion rates and antibody titers following SARS-CoV-2 vaccination, but the reasons for this diminished response are poorly understood. Here, we studied humoral cellular responses in 95 CLL 30 healthy controls after two BNT162b2 or mRNA-2173 mRNA immunizations. We found that 42% of vaccinees developed SARS-CoV-2-specific binding neutralizing antibodies (NAbs), while 32% had no response. Interestingly, 26% were seropositive,...