A5001530911- Occupational and environmental lung diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Bone and Dental Protein Studies
- Medical Imaging and Pathology Studies
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Occupational exposure and asthma
- Cholangiocarcinoma and Gallbladder Cancer Studies
- T-cell and B-cell Immunology
- Air Quality and Health Impacts
- Immune cells in cancer
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- Toxic Organic Pollutants Impact
- Pleural and Pulmonary Diseases
- RNA modifications and cancer
- Biomarkers in Disease Mechanisms
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Sleep and related disorders
- Workplace Health and Well-being
- Cancer Immunotherapy and Biomarkers
Zhengzhou University
2016-2025
Swedish Research Council
2022
Committee on Publication Ethics
2022
University of Mannheim
2022
Xi'an Peihua University
2022
Stockholm University
2022
Sun Yat-sen University
2022
Bridge University
2016
Peking University
2008-2009
Chiba University
2005
Until now, the specific pathogenesis of silicosis is not clear. Exosomal miRNAs, as a newly discovered intercellular communication medium, play an important role in many diseases. Our previous research found that serum exosomal miR125a-5p was increased patients by miRNAs high-throughput sequencing. TRAF6, target gene miR125a-5p, which involved T-cell differentiation. Furthermore, results from animal study indicate knockdown miR-125a-5p can regulate T lymphocyte subsets and significantly...
Explore methods to accurately reflect the risk level of ferrous metal foundry workplaces when silica dust concentration exceeds limit, and provide a basis for application assessment techniques in key industries with occupational exposure dust. The survey was conducted 25 casting Henan Province, China. Five health (OHRA) methods, including Risk index method, Hazard grading International Council on Mining Metals model, synthesis ratio were used assess that produced exceeded limits (OELs),...
SPARC (secreted protein acidic and rich in cysteine) is an extracellular Ca2+-binding matricellular glycoprotein associated with the regulation of cell adhesion growth. We investigated loss expression gene promoter methylation lung cancers correlated data clinicopathological features. observed 12 20 (60%) cancer lines. Treatment expression-negative lines a demethylating agent restored all cases. Methylation frequencies were 55% Primary tumours had at rate 69% (119 173), while nonmalignant...
Abstract Silicosis is an incurable occupational disease, and its pathological feature diffuse pulmonary fibrosis. Pulmonary epithelial‐mesenchymal transition (EMT) one of the important events in pathogenesis silicosis. Previous studies found that abnormal expression various microRNAs (miRNAs) involved development lung However, their roles silicosis have not been elucidated. To research biological effects miR‐34a EMT process silica‐induced fibrosis, we established model mouse intervention a...
Abstract Background Depressive symptoms and cognitive impairment often coexisted in the elderly. This study investigates effect of late-life depressive on risk mild (MCI). Methods A total 14,231 dementia- MCI free participants aged 60+ from Survey Health, Ageing, Retirement Europe were followed-up for 10 years to detect incident MCI. was defined as 1.5 standard deviation (SD) below mean standardized global cognition score. assessed by a 12-item Europe-depression scale (EURO-D). Severity...
High mobility group protein 1 (HMGB1) is a highly conserved DNA-binding nuclear that participates in the occurrence and development of silicosis. HMGB1 binds to its specific receptor activates phosphatidylinositol 3-kinase (PI3K)/protein kinase B, (PKB; Akt)/mammalian target rapamycin (mTOR) pathway. Brahma-related genes (BRG1; SMARCA4) core subunit SWI/SNF. Akt pathway through BRG1 promote proliferation prostate cancer. Glycyrrhizic acid new pharmacological inhibitor HMGB1, which may...
Introduction The prevalence of dental caries (DC) among students in developing countries has increased at an alarming rate, and nutritional status been shown to be associated with DC children adolescents inconsistent conclusions. We aimed understand the trends aged 7, 9, 12, 14 years explore relationship between status. Methods recruited 16,199 China by multi-stage, stratified, random sampling methods from 2010 2019. Permanent were measured using Decay, Loss, Filling (DMF) index rate....
Either chronic or acute exposure to dust particles may lead pneumoconiosis and lung cancer, cancer mortality among patients diagnosed with is increasing. Utilizing genome-wide sequencing technology, this study aimed identify methods decrease the number of who die from cancer. One hundred fifty-four subjects were recruited, including 54 100 healthy controls. Exosomes isolated venous blood every subject. Distinctive miRNAs identified using high throughput bioinformatics analysis predicted...
Abstract Inhaling a dangerous amount of nanoparticles leads to pulmonary inflammatory and immune disorders, which integrates several kinds cells. Exosomes are suggested play crucial role in intercellular communication via miRNA transmission. To investigate the exosomal nanoparticle phagocytosis, total 54 pneumoconiosis patients along with 100 healthy controls recruited, exosomes derived from their venous blood collected, then miRNAs profiled high‐throughput sequencing technology....
This study aimed to investigate the effect of bone marrow-derived mesenchymal stem cells (BMSCs) on silica-induced lung fibrosis in a rat model. Thirty SD rats were randomly divided into three groups: control group, silica and BMSC group (n = 10 per group). BMSCs injected successively 14th, 28th, 42nd days after exposure. All sacrificed 56 We detected pathological fibrotic changes, apoptosis, autophagy, pyroptosis their tissue by histopathological examination, hydroxyproline content assays,...