A5033144951- Effects and risks of endocrine disrupting chemicals
- NF-κB Signaling Pathways
- Reproductive Biology and Fertility
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Sperm and Testicular Function
- Immune Response and Inflammation
- Growth Hormone and Insulin-like Growth Factors
- Ovarian function and disorders
- Cytokine Signaling Pathways and Interactions
- Cell death mechanisms and regulation
- Plant tissue culture and regeneration
- Animal testing and alternatives
- Melanoma and MAPK Pathways
- Air Quality and Health Impacts
- Biomarkers in Disease Mechanisms
- Pluripotent Stem Cells Research
- Drug-Induced Hepatotoxicity and Protection
- Climate Change and Health Impacts
- Heavy Metal Exposure and Toxicity
- Retinoids in leukemia and cellular processes
- Immunotoxicology and immune responses
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- bioluminescence and chemiluminescence research
AstraZeneca (Brazil)
2025
China National Center for Food Safety Risk Assessment
2016-2024
Peking University
2015-2024
Quality and Reliability (Greece)
2022
Zhengzhou University
2011
Guilin University
2008
Guilin University of Electronic Technology
2008
Zhaotong University
2006
Huanggang Normal University
2005
Capital Medical University
1992
Relaxin-2, a well-known human hormone primarily associated with pregnancy, has shown promising cardiovascular benefits in both preclinical models and clinical trials. However, its therapeutic potential been limited due to the short half-life duration of treatment. To address this, we developed AZD3427, novel long-acting relaxin-2 analogue assessed efficacy during prolonged treatment large animal model cardiac dysfunction. Extensive protein engineering resulted fusion protein, which closely...
The potential teratogenic effects and fetal toxicity of environmental estrogenic endocrine disruptors have become a great concern in recent years, they yet to be fully characterized. In the present study, bisphenol A (BPA) genistein (GEN) on rat embryos during their critical period organogenesis were investigated using whole-embryo culture experiment. combined exposure BPA GEN explored 4 × full factorial design. Both produced concentration-dependent inhibition embryonic development,...
Chlorocholine chloride (CCC) is a plant growth regulator used worldwide that detectable in cereals, fruits and animal products. The health effects of CCC exposure have raised public concern. Our previous research showed decreased testosterone synthesis pubertal rats. However, little known about whether how impacts spermatogenesis. In this study, we BALB/c mice spermatogonia-derived GC-1 cells to examine CCC-induced spermatogenic dysfunction. vivo, led testicular weight, germ poor sperm...
Sunlight is regarded to be a cause of skin cancer, though the mechanisms underlying causation are still unclear. The genotoxic effects sunlight believed induced by pyrimidine photoproducts produced action UV portion sunlight. However, it not clear whether these modifications sole sources for mutations. In present study, we have analyzed mutagenic potential on lacZ alpha region single-stranded DNA phage M13mp2 using an SOS-deficient recA- strain and SOS-induced rec+ Escherichia coli as hosts....
Abstract Background Air pollution increases the morbidity and mortality of cardiovascular disease (CVD). Atherosclerosis (AS) is pathological basis most CVD, progression atherosclerosis increase fragile plaque rupture are mechanism relationship between atmospheric particulate CVD. The aim present study was to investigate effects coal-fired fine matter (PM 2.5 ) on expression levels atherosclerosis-related proteins (von Willebrand factor (vWF), Endothelin-1 (ET-1), intercellular adhesion...