A5025658739- Air Quality and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Metabolomics and Mass Spectrometry Studies
- Immunotoxicology and immune responses
- Carcinogens and Genotoxicity Assessment
- Animal testing and alternatives
- IL-33, ST2, and ILC Pathways
- Cytokine Signaling Pathways and Interactions
- Diet and metabolism studies
- Heavy Metal Exposure and Toxicity
- Immune Response and Inflammation
- Climate Change and Health Impacts
- Photoreceptor and optogenetics research
- Animal Virus Infections Studies
- Mast cells and histamine
- Circadian rhythm and melatonin
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Trace Elements in Health
- Gut microbiota and health
- Eosinophilic Esophagitis
- Retinoids in leukemia and cellular processes
- Viral Infectious Diseases and Gene Expression in Insects
- Adipokines, Inflammation, and Metabolic Diseases
- NF-κB Signaling Pathways
Peking University
2015-2024
China National Center for Food Safety Risk Assessment
2015-2024
King University
2020
Tokyo Medical and Dental University
2015-2017
Keio University
2013-2015
Japan Science and Technology Agency
2013
Jiangsu Academy of Agricultural Sciences
2009
Capital Medical University
2000
We evaluated whether dexamethasone augments the osteogenic capability of bone marrow-derived stromal cells (BMSCs) and muscle tissue-derived (MuSCs), both which are thought to contribute ectopic formation induced by morphogenetic protein-2 (BMP-2), determined underlying mechanisms. Rat BMSCs MuSCs were cultured in growth media with or without 10-7 M then differentiated under conditions BMP-2. The effects on cell proliferation differentiation, also BMP-2, analyzed. Dexamethasone affected not...
This study compared the effects of nonacylated and acylated anthocyanin-rich extracts on plasma metabolic profiles Zucker diabetic fatty rats. The rats were fed with anthocyanin extract from bilberries (NAAB) or purple potatoes (AAPP) at daily doses 25 50 mg/kg body weight for 8 weeks. 1H NMR metabolomics was used to changes in metabolites. A reduced fasting glucose level seen all anthocyanin-fed groups, especially groups NAAB. Both NAAB AAPP decreased levels branched-chain amino acids...
The potential teratogenic effects and fetal toxicity of environmental estrogenic endocrine disruptors have become a great concern in recent years, they yet to be fully characterized. In the present study, bisphenol A (BPA) genistein (GEN) on rat embryos during their critical period organogenesis were investigated using whole-embryo culture experiment. combined exposure BPA GEN explored 4 × full factorial design. Both produced concentration-dependent inhibition embryonic development,...
Abstract Articular cartilage has a limited capacity for spontaneous repair, and an effective method to repair damaged articular not yet been established. The purpose of this study was evaluate the effect transplantation porous hydroxyapatite collagen ( HAp / C ol) impregnated with bone morphogenetic protein‐2 BMP ‐2). To characteristics ol as drug delivery carrier recombinant human ‐2 rhBMP ‐2), adsorption release kinetics were analyzed. Porous different amounts (0, 5, 25 μg) implanted into...
Ambient air pollution was classified as carcinogenic to humans (Group 1) for lung cancer. DNA damage an important first step in the process of carcinogenesis, and could also be induced by pollution. In this study, intratracheal instillation real-time exposure system were combined establish SHP (short-term high-level PM2.5) LLPO (long-term low-level PM2.5 O3) patterns, respectively. Hierarchical levels genetic biomarkers analyzed explore effects rats. Representative repair genes from...
ABSTRACT In fracture treatment, biological bone union generally depends on the bone's natural healing capacity, even in surgically treated cases. Hydroxyapatite/collagen composite (HAp/Col) has high osteoconductivity and stimulates osteogenic progenitors. Furthermore, it potent capacity to adsorb morphogenetic proteins (BMPs). this study, we prepared an injectable HAp/Col paste evaluated its augmentation of union. effect combined with BMP‐2 was also evaluated. We used a rat femur osteotomy...
Abstract Background Air pollution increases the morbidity and mortality of cardiovascular disease (CVD). Atherosclerosis (AS) is pathological basis most CVD, progression atherosclerosis increase fragile plaque rupture are mechanism relationship between atmospheric particulate CVD. The aim present study was to investigate effects coal-fired fine matter (PM 2.5 ) on expression levels atherosclerosis-related proteins (von Willebrand factor (vWF), Endothelin-1 (ET-1), intercellular adhesion...
Anthocyanins have been reported to possess antidiabetic effects. Recent studies indicate acylated anthocyanins better stability and antioxidative activity compared their nonacylated counterparts. This study the effects of on hepatic gene expression metabolic profile in diabetic rats, using full-length transcriptomics 1H NMR metabolomics. Zucker fatty (ZDF) rats were fed with anthocyanin extract from bilberries (NAAB) or purple potatoes (AAPP) at daily doses 25 50 mg/kg body weight for 8...