A5101766066- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Effects and risks of endocrine disrupting chemicals
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Hematopoietic Stem Cell Transplantation
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Ovarian cancer diagnosis and treatment
- Cutaneous lymphoproliferative disorders research
- Chronic Lymphocytic Leukemia Research
- Pluripotent Stem Cells Research
- Hematological disorders and diagnostics
- Cancer Mechanisms and Therapy
- Healthcare and Venom Research
- Carcinogens and Genotoxicity Assessment
- Histone Deacetylase Inhibitors Research
- Angiogenesis and VEGF in Cancer
- Endometrial and Cervical Cancer Treatments
- Reproductive Biology and Fertility
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Lung Cancer Diagnosis and Treatment
Hebei Medical University
2017-2024
Second Hospital of Hebei Medical University
2017-2024
Harbin Medical University
2007-2024
Second Affiliated Hospital of Harbin Medical University
2008-2015
National Medical Products Administration
2013
Peking University
2009-2013
The potential teratogenic effects and fetal toxicity of environmental estrogenic endocrine disruptors have become a great concern in recent years, they yet to be fully characterized. In the present study, bisphenol A (BPA) genistein (GEN) on rat embryos during their critical period organogenesis were investigated using whole-embryo culture experiment. combined exposure BPA GEN explored 4 × full factorial design. Both produced concentration-dependent inhibition embryonic development,...
The present study aims to clarify whether hyaluronan binding protein 1 (HABP1/p32/C1QBP) is an indicator of peritoneal and lymph node metastasis in epithelial ovarian cancer (EOC), which the authors' knowledge not previously reported by others. Western blot analysis demonstrated that HABP1 was highly overexpressed most metastatic lesions. Of 89 patients whose primary tumors showed high expression on immunohistochemical staining, 85 (95.5%) presented metastases 43 (48.3%) had metastases....
Telomerase activity (TA) is reactivated in more than 90% of all human malignant tumors and normal somatic cells that lack TA. Thus, TERT (hTERT) a promising target tumor treatment. RNA interference powerful tool for gene silencing. In this study, we constructed siRNA#1-4 to knock down hTERT. All siRNAs were able downregulate hTERT differently chose siRNA#3 (most effectively) the following experiments. We studied effects on cell proliferation, cycle, apoptosis radiosensitivity using SiHa...
The occurrence of acute myeloid leukemia (AML) with a simultaneous diagnosis breast cancer (BC) is rarely reported in the literature. present study reports case 50‑year‑old female patient diagnosed AML coexisting metastatic BC. Following one cycle treatment azacytidine combination oral venetoclax for AML, achieved complete remission incomplete hematological recovery. In addition, mass left was smaller following adjuvant chemotherapy. However, due to refusal from accept an allogeneic...
In the present study, anticancer activity of chamaejasmine towards A549 human lung adenocarcinoma cells was investigated. order to explore underlying mechanism cell growth inhibition chamaejasmine, cycle distribution, ROS generation, mitochondrial membrane potential (Δψm) disruption, and expression cytochrome c, Bax, Bcl-2, caspase-3, caspase-9 PARP were measured in cells. Chamaejasmine inhibited a time dose-dependent manner. The IC50 value 7.72 µM after 72 h treatment. arrested G2/M phase...
Adults with relapsed acute lymphoblastic leukemia (ALL) have a poor prognosis, especially in patients who within 6 months of complete remission 1 (CR1). Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the treatment choice. However, this can only be considered after 2 (CR2) achieved. Therefore, bridging urgently needed. In present study, we report adult B-cell ALL case that achieved CR2 CD19-directed chimeric antigen receptor (CAR)-modified T (CAR-T) therapy. After...
Vascular endothelial growth factor (VEGF) plays an important role in the initiation and regulation of angiogenesis various tumor tissues. Recently, several therapeutic approaches based on inhibition VEGF function during angiogenesis. However, cervical cancer may not be limited to angiogenesis, signaling for ability these cells evade apoptosis progress towards invasive metastatic diseases. In our study, expression was knocked down using plasmid-based RNA interference (RNAi) detected carcinoma...
It is well known that microRNAs (miRNAs) interfere with the progression of various human malignancies. This article aimed at exploring regulating role miR-342-3p in acute myeloid leukemia (AML) and its mechanism.We used Gene Expression Omnibus (GEO) database to determine differential expression patterns AML patients' plasma cells as healthy individuals' T cells. Quantitative real-time PCR Western blotting were performed for cell SRY-related high-mobility-group box (SOX12) quantification,...
To investigate the influence of telomerase activity, apoptosis, radiosensitivity cervical cancer after siRNA-mediated knockdown RNA and evaluate in vivo growth with gene interference.We studied siRNA-targeting-telomerase transfection into Hela cell line. Expression hTERC mRNA was detected by RT-PCR activity measured TRAP assay. Growth inhibition determined MTT assay cells examined colony formation In addtion, effects were injection siRNA-transfected nude mice.The siRNA effectively...
Programmed cell death protein-1 inhibitor combined with chimeric antigen receptor T cells in the treatment of relapsed refractory non-Hodgkin lymphoma: A case report
Chlorogenic acid displays several important roles in the therapeutic properties of many herbs, such as antioxidant activity, antibacterial, antiviral, scavenging free radicals and exciting central nervous system. Only about one-third chlorogenic was absorbed its prototype, therefore, gut metabolites play a more role acid. It is necessary to consider not only bioactivities but also metabolites. This review focuses on potential activities mechanisms system diseases.
Trichostatin A (TSA) is a histone deacetylase (HDAC) inhibitor. We here investigated its effects on proliferation and apoptosis of the CNE2 carcinoma cell line, attempted to establish genome-wide DNA methylation alteration due differentially acetylation status. After cells were treated by TSA, inhibitory rate was examined with CCK8 kit, determined flow cytometry. Compared control, TSA inhibited growth induced apoptosis. Furthermore, found induce as assessed array. Overall level higher than...
Abstract Genetic association between SUMO-specific protease 1 (SENP1) and acute myeloid leukemia (AML) has been validated. However, the mechanism by which SENP1 affects AML proliferation, apoptosis, autophagy remains unknown. The levels of polypyrimidine tract-binding protein (PTBP1) were measured in patients with AML, cell lines, xenograft tissues. effects on beclin (BECN1)-dependent assessed through vitro vivo loss- or gain-of-function experiments. SUMOylation analysis using...
This study aimed to verify a novel potential indicator of disease progression in acute myeloid leukemia (AML) patients. Bone marrow samples were collected from 27 AML patients and controls without hematological malignancies. Polypyrimidine tract-binding protein 1 (PTBP1) expression bone was measured, the association PTBP1 with French-American-British (FAB) classification, cytogenetics, risk stratification, complete remission (CR) rate analyzed. The correlation between Ki-67/p53 ultimately...
cervical squamous cell carcinoma (CSCC) is the second gynecological tumors that seriously threaten women's life quality. Circular RNA (circRNA) related with cancer carcinogenesis and radiosensitivity. To investigate performance of hsa_circ_0007905 (circSTX6) on regulating cellular activities radiosensitivity in CSCC. The relative expression circSTX6 different tissue samples was detected by RT-qPCR. activity influence cells measured CCK-8 Transwell assays. survival fractions were after...