A5084950552- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Sphingolipid Metabolism and Signaling
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Caveolin-1 and cellular processes
- Cancer Mechanisms and Therapy
- Pancreatic function and diabetes
- Colorectal Cancer Screening and Detection
- Cancer-related gene regulation
- Regulation of Appetite and Obesity
- Autophagy in Disease and Therapy
- Wnt/β-catenin signaling in development and cancer
- Gastrointestinal disorders and treatments
- Ginkgo biloba and Cashew Applications
- NF-κB Signaling Pathways
- Colorectal Cancer Treatments and Studies
- Appendicitis Diagnosis and Management
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Cells and Metastasis
- Hippo pathway signaling and YAP/TAZ
- Diet, Metabolism, and Disease
- Intestinal and Peritoneal Adhesions
- Cancer Research and Treatments
- TGF-β signaling in diseases
Guangxi Medical University
2016-2025
National Natural Science Foundation of China
2023
Weatherford College
2020
First Affiliated Hospital of GuangXi Medical University
2009-2018
Southern Medical University
2015
Nanfang Hospital
2015
The current study aims to investigate the significance of N6-methyladenosine (m6A) methylation-related genes in clinical prognosis hepatocellular carcinoma (HCC) using bioinformatics analyses based on Cancer Genome Atlas (TCGA) database. Transcriptome data and corresponding m6A (including 15 genes) were obtained from TCGA Differential expression was identified. Survival curves subgroups gene levels plotted. We selected potential predictive analyzed their prognostic values methods. Eleven...
Studies suggest a tumor-promoting function of sphingosine kinase 1 (SphK1) in some types human tumors, however, its effect on colon cancer is still unclear. The aims this study were to investigate the roles SphK1 progression and tumor cell phenotypic changes cancer. Moreover, focal adhesion (FAK) pathway expression intercellular molecule‑1 (ICAM‑1) vascular (VCAM‑1) detected explore mechanisms action. In study, SphK1, FAK phospho-FAK (p-FAK) was analyzed 66 surgical specimens primary matched...
Sphingosine kinase 1 (SphK1) plays an important role in colorectal carcinoma metastasis. However, whether SphK1 modulates epithelial-mesenchymal transition (EMT)-related marker expression and the underlying mechanisms remain unclear. In this study, order to clarify issue, we used various cancer (CRC) cell lines, Caco2, HT29, RKO HCT116. Each of lines was divided into 3 groups as follows: control group, SKI-Ⅱ (SphK1 inhibitor) group PF-562271 [focal adhesion (FAK) inhibitor] group. The...
It was demonstrated that Sphingosine kinase 1 (SphK1) promotes tumor progression and confers the malignancy phenotype of colorectal cancer by activating focal adhesion (FAK) pathway. However, further clarification is required to determine if SphK1 metastasis inducing epithelial‑mesenchymal transition (EMT), its mechanisms have not been fully elucidated. Immunohistochemistry staining used detect protein expression in normal colonic mucosa tissues tissues. Cells were transfected overexpress...
Abstract A sphingolipid metabolite regulator, sphingosine kinase 1 (SPHK1), plays a critical role in the development of colorectal cancer (CRC). Studies have demonstrated that invasion and metastasis CRC are promoted by SPHK1-driven autophagy. However, exact mechanism SPHK1 drives autophagy to promote tumor progression remains unclear. Here, immunohistochemical detection showed expression necrosis factor receptor-associated factor-6 (TRAF6) human tissues was stronger than adjacent normal...
Conclusions regarding the suction techniques of EUS-FNB remain controversial. This study aimed to compare diagnostic accuracy dry versus wet technique in solid pancreatic lesions (SPLs) and determine optimal number passes for EUS-FNB. investigation was conducted as a multicenter, randomized, controlled, non-inferiority trial. Patients with SPLs were randomly allocated receive either or technique. The primary outcome accuracy. secondary outcomes included sensitivity, specificity, needle...
Sphingosine kinase 1 (SphK1) is a master that catalyzes the synthesis of sphingosine phosphate and participates in regulation cell proliferation autophagy. The present study aimed to assess effects activation SphK1/extracellular signal‑regulated (ERK)/phosphorylated (p‑)ERK pathway autophagy colon cancer (HT‑29) cells. Inverted fluorescence microscopy was used detect expression green fluorescent protein (GFP) SphK1‑overexpressing HT‑29 cells [SphK1(+)‑HT‑29] negative control (NC‑HT‑29)....
Colorectal cancer (CRC) is one of the most common malignancies worldwide. Unlike endothelium-dependent vasculature, vasculogenic mimicry (VM) an alternative type blood supply in tumors that frequently associated with poor patient outcome. Nectin-4 serves a vital role formation and maintenance adherens junctions; integrin β-1 (ITGB1) promotes tumor invasion, metastasis VM formation. In present study, analysis nectin-4 mRNA expression database The Cancer Genome Atlas (TCGA) was combined...
BACKGROUND Ginkgo biloba extract (EGb761), a standard of the Chinese traditional medicine biloba, plays an anti-tumor role in various cancers. However, whether EGb761 is involved invasion and metastasis gastric cancer remains unclear. MATERIAL AND METHODS In current study, cell viability assay, Western blotting, wound-healing Transwell orthotopic transplantation model were performed to explore effects on cancer. RESULTS vitro, results showed that suppressed proliferation cells dose-dependent...
Abstract Invasion and metastasis are the main causes of colorectal cancer (CRC)‐related death. Accumulating evidence suggested that sphingosine kinase 1 (SphK1) promoted CRC autophagy played an important role in SphK1 promoting malignancy. However, mechanism by which SphK1‐driven promotes invasion remains to be clarified. In present study, immunohistochemical detection showed expression paxillin was higher human tissues than those normal mucosal tissues, they were both associated with TNM...
The bile infection may already exist before the administration of an interventional procedure, despite no clinical manifestations cholangitis detected. Blood cultures remained negative even in more than half febrile cases with cholangitis. Risk factors associated bacterial growth intervention are not well defined. To establish profiles isolated from samples and to identify risk for colonization system. Individuals who underwent endoscopic retrograde cholangiopancreatography (ERCP)...
Colorectal cancer (CRC) is one of the most fatal types worldwide. This study aimed to determine predictive and prognostic values cell division cycle associated protein 7 (CDCA7) in CRC. Firstly, relationship between CDCA7 CRC was assessed through bioinformatics analysis. Subsequently, expression levels were detected various lines, as well 15 fresh human tissues their paired adjacent normal colorectal using reverse transcription‑quantitative PCR western blotting. Additionally,...
<abstract> <sec><title>Background</title> Pancreatic adenocarcinoma (PAAD) is one of the most common malignant tumors with high mortality rates and a poor prognosis. There an urgent need to determine molecular mechanism PAAD tumorigenesis identify promising biomarkers for diagnosis targeted therapy disease. </sec> <sec><title>Methods</title> Three GEO datasets (GSE62165, GSE15471 GSE62452) were analyzed obtain differentially expressed genes (DEGs). The PPI networks hub identified through...
NIBP, a novel nuclear factor-κB (NF-κB)-inducing kinase (NIK) and IκB β (IKKβ) binding protein, directly interacts with NIK IKKβ, acts as the 'bridge' of NF‑κB classical alternative signaling pathways. However, its influence on epithelial‑mesenchymal transition markers in colon cancer remains to be fully elucidated. The aim present study was investigate roles NIBP impacting expression E‑cadherin, CD44 vimentin. In study, associations between vimentin clinical samples were analyzed by making...
Abstract Background Recently, several novel scoring systems have been developed to evaluate the severity and outcomes of acute pancreatitis. This study aimed compare effectiveness conventional in predicting Methods Patients treated between January 2003 August 2020 were reviewed. The Ranson score (RS), Glasgow (GS), bedside index pancreatitis (BISAP), pancreatic activity system (PASS), Chinese simple (CSSS) determined within 48 h after admission. Multivariate logistic regression was used for...
The nuclear factor (NF)-κB pathway has been implicated in colorectal cancer (CRC) tumorigenesis. Here, we investigated the role of a novel NIK- and IKKβ-binding protein (NIBP) CRC metastasis through activation canonical NF-κB pathway. NIBP, p-p65, matrix metalloproteases (MMPs) were assessed by immunohistochemistry 114 tissues, time to was recorded after surgery. Furthermore, activity pathway, MMP expression, metastatic potential HT-29 cells overexpressing NIBP treatment with inhibitor...
The goal of this study was to clarify the protective role Wnt/β-catenin pathway agonist SKL2001 in a rat model Caerulein-induced acute pancreatitis. AR42J cells and rats were divided into 4 groups: control, Caerulein, + control. Cell apoptosis examined using flow cytometry. Hematoxylin-eosin staining performed observe pathological changes pancreatic small intestinal tissues. Inflammatory cytokines detected by enzyme-linked immunosorbent assay (ELISA), while genes related quantified...
Background Despite the identification of many signaling pathways involved in colorectal cancer (CRC) tumorigenesis, metastatic CRC still remains one major causes related death. NIK and IKKβ-binding protein (NIBP) is key regulators NF-κB pathway, which has been implicated metastasis. The aim this study was to investigate possible role NIBP metastasis through its regulation NF-κΒ extracellular regulated kinase/c-Janus kinase (ERK/JNK) pathways. Methods In NIBP, phosphorylated (p)-p65,...