A5053354746- Cytokine Signaling Pathways and Interactions
- PI3K/AKT/mTOR signaling in cancer
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Cancer-related gene regulation
- Neuropeptides and Animal Physiology
- Biocrusts and Microbial Ecology
- Inflammation biomarkers and pathways
- Chronic Myeloid Leukemia Treatments
- Hematological disorders and diagnostics
- Cell Adhesion Molecules Research
- Algal biology and biofuel production
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Nitric Oxide and Endothelin Effects
- Advanced biosensing and bioanalysis techniques
- Ion channel regulation and function
- Immune Response and Inflammation
- Hemophilia Treatment and Research
Hebei Medical University
2016-2025
Second Hospital of Hebei Medical University
2016-2025
Handan College
2007
Hebei Seismological Bureau
2006
<title>Abstract</title> Acute myeloid leukemia (AML) as the second most common hematological malignancy remains currently incurable. In this study, we found protein disulphide isomerase family (PDIs) was expressed in primary cells, with particular emphasis on ERP5 and ERP57. The compound PACMA31 demonstrated ability to inhibit proliferation, enhance differentiation, exacerbate oxidative stress, induce apoptosis AML cells. RNA sequencing analysis revealed that impeded proliferation of cells...
Hematopoietic stem cell (HSC) transplantation could be of therapeutic value for aplastic anemia (AA) patients, and immunosuppressants may facilitate the efficiency procedure. As anti-inflammatory cytokine interleukin-11 (IL-11) has a thrombopoietic effect, its use in cases chronic bone marrow failure, such as AA, been proposed to induce HSC function. However, putative mechanisms that support this process remain poorly defined. We found decreased miR-204-5p levels were coincident with...
Adults with relapsed acute lymphoblastic leukemia (ALL) have a poor prognosis, especially in patients who within 6 months of complete remission 1 (CR1). Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the treatment choice. However, this can only be considered after 2 (CR2) achieved. Therefore, bridging urgently needed. In present study, we report adult B-cell ALL case that achieved CR2 CD19-directed chimeric antigen receptor (CAR)-modified T (CAR-T) therapy. After...
The Myc antagonists Mad1, Mxi1 and Rox proteins share two highly conserved domains, Sin3-interacting domain (SID) basic helix-loop-helix leucine zipper (bHLHzip), which are essential for these to function during molecular switching from proliferation differentiation. In an attempt identify mutations in genes human haematological malignancies, we screened 10 haematopoietic cell lines, bone marrow mononuclear cells (BMMNC) 26 patients with malignancies peripheral blood (PBMNC) 30 healthy...
Programmed cell death protein-1 inhibitor combined with chimeric antigen receptor T cells in the treatment of relapsed refractory non-Hodgkin lymphoma: A case report
To provide clinical basis for the diagnosis and treatment of chronic neutrophilic leukemia (CNL) to possible molecular targets treatment.By summarizing data 14 patients with CNL, characteristics, gene mutation types prognostic factors were analyzed.Among males (9 cases) more than females (5 cases), a median age 57 years old. The detection rate CSF3R was 92.86% (13/14), including 12 cases (85.71%) T318I 1 case Y799X mutation, only not detected CSF3R. ASXL1 in 42.86% (6/14) patients, all which...
To observe the clinical efficacy and safety of hypomethylating agent therapy in chronic myelomonocytic leukemia (CMML).
To explore the diagnosis and treatment of acquired hemophilia A (AHA) based on analysis clinical data.
The present case report describes a rare of T cell acute lymphoblastic lymphoma (T-LBL) in the lymph node with myeloid sarcoma pericardium. A 33-year-old Chinese male was admitted to hospital on 4 July 2015 exhibiting fever and having experienced wheezing fatigue for previous 7 days. Routine pathological, computed tomographic, cytological immunophenotypic observations revealed diagnosis T-LBL August 2015, without evidence bone marrow (BM) involvement. patient received induction chemotherapy...
To investigate the effects of artesunate (ART) on proliferation, cell cycle and apoptosis SKM-1 cells in vitro to explore underlying mechanisms.After were treated with different concentrations ART, proliferation was determined by CCK-8 method. Apoptosis distribution detected flow cytometry. Both DCFH-DA fluorescent probe Fluo-3-Am used detect changes intracellular reactive oxygen species (ROS) calcium ion concentration. Western blot measure protein levels BCL-2, BAX, BAD, P-BAD, survivin...
In order to enhance the understanding of thrombotic thrombocytopenic purpura (TTP), clinical features, laboratory characteristics, treatment and outcome 14 patients with TTP were retrospectively analyzed investigated. The results showed that 7 out had predisposing factors, such as pregnancy in 4 cases, infection 3 systemic lupus erythematosus (SLE) 1 case hematopoietic stem cell transplantation (HSCT) case. Fourteen all neuropsychological symptoms, hemolytic anemia negative-Coombs test,...
Acute demyelinating myelopathy after allogeneic hematopoietic stem cell transplantation (HSCT) is rare, and the exact pathogenesis remains unclear. Here, we report case of a 20-year-old patient with B-cell acute lymphocyte leukemia (B-ALL) who developed approximately 10 months HSCT. Magnetic resonance imaging revealed high T2 signal intensity lesions from C2-T4 levels spinal cord. Treatments doses corticosteroids, immunoglobulins, rituximab improved his neurologic symptoms, he achieved 44...