A5076246850- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Cytokine Signaling Pathways and Interactions
- Phytochemistry and Bioactive Compounds
- Complementary and Alternative Medicine Studies
- Asthma and respiratory diseases
- Therapeutic Uses of Natural Elements
- Allergic Rhinitis and Sensitization
- Lipoproteins and Cardiovascular Health
- Immune Response and Inflammation
- Retinoids in leukemia and cellular processes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Inflammation biomarkers and pathways
- Neuroendocrine Tumor Research Advances
- Antiplatelet Therapy and Cardiovascular Diseases
- Biosimilars and Bioanalytical Methods
- Acupuncture Treatment Research Studies
- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
- Respiratory Support and Mechanisms
- Atrial Fibrillation Management and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Tryptophan and brain disorders
- Lung Cancer Research Studies
- Vitamin D Research Studies
Capital Medical University
2016-2024
Beijing Hospital of Traditional Chinese Medicine
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Southwest Forestry University
2024
Yunnan Environmental Protection Bureau
2024
Beijing Tian Tan Hospital
2023
Yuhuangding Hospital
2021
Qingdao University
2021
Beijing Tongren Hospital
2021
Analysis Group (United States)
2021
The flavonoid astilbin is the major active component extracted from rhizome of Smilax glabra, which has been widely used in China to treat inflammatory and autoimmune diseases, Psoriasis a common chronic disease T helper 17 (Th17) cells play an important role, provoking inflammation. We employed imiquimod (IMQ)-induced psoriasis-like mouse model investigate effect Mice were administered 25 50 mg/kg astilbin. Inflammation lesions was assessed by histology, circulating levels flow cytometry...
The long-term benefit-risk profiles of licensed and investigational treatments for moderate-to-severe plaque psoriasis have not been fully characterized.Randomized controlled trials (RCTs) were identified through a systematic literature review 2 May 2021. Bayesian network meta-analyses (NMAs) conducted to compare the efficacy (Psoriasis Area Severity Index [PASI] 75/90/100 [at least 75/90/100% reduction in PASI score from baseline] response) safety outcomes (any adverse event [AE], any...
Abstract Psoriasis is a common, chronic multifactorial inflammatory skin disease with both genetic and environmental components. A number of studies have suggested that psoriasis episodes are often preceded by stressful life events. Nevertheless, the underline mechanisms stress in remain unexplored. To address this question, we established an emotional mouse model induced empty bottle stimulation, applied imiquimod (IMQ), ligand TLR7/8 effective potent immune activator, on dorsal to induce...
Psoriasis is a common chronic inflammatory hypertrophic skin disease characterized by abnormal proliferation and differentiation of keratinocyte immune T cell. The pathogenesis psoriasis has not been fully elucidated there no effective therapy in clinic. As traditional Chinese medicine formula, Yangxue Jiedu Soup (YJS) used to treat diseases caused Yin Deficiency Blood Dryness. purpose present study was investigate the therapeutic effect molecular mechanism YJS on model mice. Results showed...
Psoriasis is a common autoimmune disease. Acupuncture-related techniques have been widely used to treat psoriasis since its ability engage neuronal function, the immune system, and other systems well documented. This study aimed investigate compare effects of three acupuncture-related in psoriasis-like skin inflammatory responses explore possible involved mechanisms. Imiquimod (IMQ)-induced mice were treated with acupuncture needling, electroacupuncture, or fire acupuncture. Methotrexate...
Abstract Scope: The global prevalence of obesity has significantly increased, presenting a major health challenge. High‐fat diet (HFD)‐induced is closely related to the disease severity psoriasis, but mechanism not fully understood. Methods and results: study utilizes HFD‐induced model along with an imiquimod (IMQ)‐induced psoriasis‐like mouse (HFD‐IMQ) conduct transcriptomics metabolomic analyses. obese mice exhibits more severe lesions compared normal (ND)‐IMQ mice. expression genes IL‐17...
BackgroundPsoriasis patients are at increased risk of developing lipid metabolism disturbances. Both psoriasis and dyslipideamia not only closely interact in disease development, but occur as mutual side effects some medicine treatment. The interactive mechanism the two diseases is complicated still unclear.ObjectiveHere, we proposed applying imiquimod on dorsal skin ApoE−/− mice to establish a composite animal model which formed psoriasiform lesions under hyperlipidemic condition.MethodBy...
Abstract Background Psoriasis is a chronic, immune-mediated disorder with chronic plaque psoriasis being the primary manifestation during remission stage. Patients often have slow course and long history of disease. The refractory type stubborn rash that does not subside easily. We designed this randomized controlled trial to compare effectiveness relapse rates in patients treated either acupuncture, moxibustion or calcipotriol ointment. ultimate aim study select an effective traditional...
Psoriasis is a chronic inflammatory skin disorder in humans, and the reaction plays an important role development onset of psoriasis. 4'-O-β-D-glucosyl-5-O-methylvisamminol (4GMV) one major active chromones isolated from Saposhnikoviae divaricata (Turcz.) Schischk, which has been reported to exhibit excellent anti-inflammatory activities. However, possible therapeutic effect on psoriasis underlying mechanism not reported. Thus, aim this study was investigate protective 4GMV imiquimod...
Clinical studies have demonstrated the anti-psoriatic effect of LiangXueJieDu (LXJD) herbal formula. However, systemic mechanism and targets LXJD formula not yet been elucidated. In present study, a systems pharmacology approach, metabolomics, experimental evaluation were employed. First, by systematic absorption-distribution-metabolism-excretion (ADME) analysis, 144 active compounds with satisfactory pharmacokinetic properties identified from 12 herbs using TCMSP database. These could be...
Psoriasis is associated with an increased prevalence of cardiovascular risk factors, including metabolic syndrome (MetS). To date, it unclear whether MetS causes differences in outcomes psoriatic patients coronary artery disease.We conducted a retrospective cohort study to determine the effects disease. Comparisons were made between and without MetS. Cox regression analysis Kaplan-Meier survival used evaluate association variables.Of 307 disease, 94 met criteria (30.6%) for Individuals more...
Introduction: The incidence of psoriasis vulgaris is increasing worldwide. Chronic recurrence the disease, as well accompanying cardiovascular metabolic syndrome, and depression has affected physical mental health these patients. Psoriasis a difficult major disease in dermatology field. Short-term curative effects using conventional therapy for made strides. However, traditional Chinese medicine (TCM) treatment long-term advantages but lacks scientific clinical evidence its use. This study...
Background Storz Professional Image Enhancement System (SPIES) endoscopy is an optical method to enhance the visualization of microvasculature on mucosal surface and characterize epithelial changes.Objective In this study, we aimed detect sinonasal inverted papilloma (SIP) in and/or mucosa using SPIES endoscopy.Materials methods A total 115 subjects, including 80 patients with SIPs or nasal polyps (NPs) 35 healthy controls were investigated white light (WLE) endoscopy. All lesions diagnosed...