A5101787814- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Mast cells and histamine
- Ecology and Vegetation Dynamics Studies
- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and Biological Activities
- Phytochemical compounds biological activities
- Circadian rhythm and melatonin
- Wound Healing and Treatments
- Soil Carbon and Nitrogen Dynamics
- Plant responses to water stress
- Biological Activity of Diterpenoids and Biflavonoids
- Plant Water Relations and Carbon Dynamics
- Metabolomics and Mass Spectrometry Studies
- Rangeland Management and Livestock Ecology
- Flavonoids in Medical Research
- Natural Compound Pharmacology Studies
- Mitochondrial Function and Pathology
- Polymer Nanocomposites and Properties
- Phytochemistry and biological activity of medicinal plants
- Traditional and Medicinal Uses of Annonaceae
- Allergic Rhinitis and Sensitization
- Silymarin and Mushroom Poisoning
Chinese Academy of Agricultural Sciences
2024
Capital Medical University
2015-2024
Beijing Hospital of Traditional Chinese Medicine
2015-2024
Institute of Environment and Sustainable Development in Agriculture
2024
Henan Normal University
2024
Shanxi Agricultural University
2022
Shenyang University of Chemical Technology
2021
The difference in compatibility at the molecular level can lead to a change of microphase separation structure thermoplastic polyurethanes blend systems, which will improve their thermal and mechanical properties. In this study, TDI-polyester based TPU was blended with MDI-polyether-based MDI-polyester TPU, different ratios. system, obvious reduction melting temperature high-temperature component indicates its hard segments be mutually integrated other component. For TPU/MDI-polyether...
AbstractPhytochemical investigation on the aqueous extract from Dryopteris fragrans led to isolation of one new chromone glycoside, frachromone C (1), and coumarin dryofracoulin A (2), together with known undulatoside (3). Their structures were elucidated by a combination 1D 2D NMR, HRMS, chemical analysis. Compounds 1–3 exhibited inhibition nitric oxide production in lipopolysaccharide induced RAW 264.7 macrophages their IC50 values 45.8, 65.8, 49.8 μM, respectively.Keywords:...
Sepsis is reported to be an unusual systemic reaction infection, accompanied by multiple-organ failure. Sepsis-induced cardiomyopathy, defined as damages and dysfunction of the heart, essential in pathogenesis sepsis. Traditional Chinese formula, which has long been used improve situation patients through multitarget regulation, now gradually being complementary therapy. The present study aimed investigate effect Qiang-Xin 1 (QX1) a traditional herbal medicine designed for cardiac...
Polygonum multiflorum Thunb. (PM) is one of the most frequently used natural products in China. Its hepatotoxicity has been proven and reported. However, chronic PM toxicity a dynamic process, few studies have reported long-term hepatotoxic mechanism or its nephrotoxicity. To elucidate nephrotoxicity induced by after different administration times, samples from rats were systematically investigated traditional biochemical analysis, histopathological observation, nontargeted metabolomics. The...
Cardiac dysfunction is a critical manifestation of sepsis-induced multiorgan failure and results in the high mortality sepsis. Our previous study demonstrated that traditional Chinese medicine formula, Qiang-Xin 1 (QX1), ameliorates cardiac tissue damage septic mice; however, underlying pharmacology mechanism remains to be elucidated. The present was aimed at clarifying protective QX1 formula on dysfunction. moderate sepsis model mice established by cecal ligation puncture surgery. Treatment...
Psoriasis (PA) is a chronic autoimmune disease of the skin that adversely affects patients' quality life. Yangxue Jiedu Fang (YXJD) has been used for decades to treat psoriasis in China. However, its antipsoriatic mechanisms are still poorly understood. In this study, we explored effects YXJD on angiogenesis and apoptosis microvessels PA, underlying HUVEC cells transfected by Survivin overexpression plasmid mouse model imiquimod-induced relationship between VEGF (vascular endothelial growth...
The pathological mechanism of psoriasis and dyslipidemia comorbidity is unclear, there are few reports on therapy. By establishing an animal model ApoE −/− mice induced by imiquimod (IMQ), we explored the effects Liangxue Jiedu formula (LXJDF), a traditional Chinese herb medicine, through PI3K/Akt/mTOR pathway. experiment was divided into control group, LXJDF high-dose low-dose positive drug (atorvastatin) group. Each group given continuous oral administration once day. After 3 weeks, dorsal...
Common chronic wounds include diabetic ulcers, venous and pressure ulcers. The traditional Chinese medicine Huiyang Shengji decoction (HYSJD) has been shown to promote the healing of wounds, however, its pharmacological mechanism is still unclear.This study aimed determine HYSJD in promoting skin ulcers.Ultra-performance liquid chromatography was combined with tandem mass spectrometry (UPLC-MS/MS) analyze main components absorbed mouse serum at 30 min after oral administration HYSJD. db/db...
psoriasis is a chronic inflammatory skin disease. The accumulation of IL-17 cytokines in the lesions leads to epidermis proliferation. Traditional Chinese medicine has significant effect on treatment. Among them, Tuhuaiyin representative prescription, which an outstanding curative acute and remission stage.To reveal target molecular mechanism Tuhuaiyin, systematic pharmacology platform database screening were used construct interaction network with compounds, targets diseases. intervention...
Rodent-mediated seed dispersal largely affects the regeneration and colonization of forest vegetation. However, due to steep topography, complex terrains heavy anthropogenic logging from 1970s 1990s, secondary succession process is greatly inhibited where temperate deciduous broadleaf forests were zonal Previous studies have ignored limitation mechanism among different slope positions in montane forests. We established 90 sample plots Taihang Mountains (i.e., ridge, midslope valley),...
Rodent-mediated seed dispersal largely affects the regeneration and colonization of forest vegetation. However, due to steep topography, complex terrains heavy anthropogenic logging from 1970s 1990s, secondary succession process is greatly inhibited where temperate deciduous broadleaf forests were zonal Previous studies have ignored limitation mechanism among different slope positions in montane forests. We established 90 sample plots Taihang Mountains (i.e., ridge, midslope valley),...
Abstract Background Psoriasis is an immune-mediated inflammatory skin disease. The circadian clock influence immune cells and control the skin’s response. In this study, we observed effect of LiangxueJiedu Formula (LXJDF) on imiquimod-induced per2-knockout mice to explore mechanism Chinese medicinal herbs in improving inflammation via clock. Methods per2 −/− were randomly divided into model group, LXJDF positive drug group (dexamethasone). dorsal was smeared with imiquimod at 9:00 AM (ZT1),...
Two new cadinane-type sesquiterpenoid glycosides, dryopteristerpeneA (1) and dryopteristerpeneB (2), were isolated from the aqueous extract of Dryopterisfragrans. Their structures determined by spectroscopic data analysis electronic circular dichroism (ECD) calculations. Compounds 1 2 exhibited inhibition on nitric oxide production in lipopolysaccharide induced RAW 264.7 macrophages with their IC50 values 60.5 59.8 μM, respectively.
Silybin, an active component in the plant Silybum marianum (L.) Gaertn., is commonly used to protect against liver disease. We investigated silybin's protective potential rat emodin-induced injury 4 weeks. It was found that aspartate aminotransferase and direct bilirubin serum biomarkers for toxicity significantly increased, histopathology revealed cholestasis necrosis rats administered emodin alone, whereas total bile acid levels silybin simultaneously were changed compared alone. Liver...
Objective To study the quality standard of Qingre-Chushi granules, including TLC identification main components and ultra performance liquid chromatography determination components, so as to lay a foundation for further development new drugs. Methods Seven constituents, Gentianae Radix et Razoma, Scutellaria Radix, Plantaginis Herba, Rehmanniae Imperarae Rhizoma, Poria Glycyrrhiza were determined by TLC. The content gentiopicroside Baicalin in Gentiana officinalis baicalensis was UPLC...