A5100322592- Wnt/β-catenin signaling in development and cancer
- Dermatology and Skin Diseases
- Proteoglycans and glycosaminoglycans research
- Muscle Physiology and Disorders
- Cancer-related gene regulation
- Allergic Rhinitis and Sensitization
- Wound Healing and Treatments
- Immune cells in cancer
- Hemoglobin structure and function
- Immune Response and Inflammation
- Protein Degradation and Inhibitors
- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Kruppel-like factors research
- Glycosylation and Glycoproteins Research
- Cancer and Skin Lesions
- Bioactive natural compounds
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
China Medical University
2008-2025
Chinese Academy of Sciences
2005-2025
Center for Excellence in Brain Science and Intelligence Technology
2020-2025
Shandong Jiaotong University
2019-2025
Cleveland Clinic Lerner College of Medicine
2014-2024
Gansu University of Traditional Chinese Medicine
2024
Beijing Hospital of Traditional Chinese Medicine
2019-2024
Capital Medical University
2019-2024
Zhengzhou University of Industrial Technology
2024
Shandong University of Technology
2024
β-Hydroxy-β-methylbutyrate (HMB) is a leucine metabolite shown to reduce protein catabolism in disease states and promote skeletal muscle hypertrophy response loading exercise. In this study, we evaluated the efficacy of HMB wasting recovery following disuse aged animals. Fisher 344×Brown Norway rats, 34 mo age, were randomly assigned receive either Ca-HMB (340 mg/kg body wt) or water vehicle by gavage ( n = 32/group). The animals received 14 days hindlimb suspension (HS, 8/diet group)...
Objective Intestinal fibrosis is considered an inevitable consequence of chronic IBD, leading to stricture formation and need for surgery. During the process fibrogenesis, extracellular matrix (ECM) components critically regulate function mesenchymal cells. We characterised composition ECM in fibrostenosing Crohn’s disease (CD) control tissues. Design Decellularised full-thickness intestinal tissue platforms were tested using three different protocols, phenotypes was explored by proteomics...
The levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) in purified calf thymus DNA and HeLa cells were measured following exposure to either UVC, UVB or UVA wavelengths. This damage was quantitated using HPLC coupled with an electrochemical detector. 8-oxodGuo induced a linear dose-dependent fashion by each portion the UV spectrum at yields 100, 0.46 0.16 per 10(5) 2'-deoxyguanosine (dGuo) kJ/m2 for UVA, respectively. However, amount irradiated these sources decreased approximately...
Perfluoroalkyl substances (PFASs) are a group of highly persistent chemicals that widespread contaminants in wildlife and humans. Exposure to PFAS affects thyroid homeostasis experimental animals possibly The objective this study was examine the association between plasma concentrations PFASs stimulating hormone (TSH) among pregnant women.A total 903 women who enrolled Norwegian Mother Child Cohort Study from 2003 2004 were studied. Concentrations thirteen TSH measured samples collected...
Understanding selectivity-dependent molecular mechanism of inhibitors towards CDK2 over CDK6 is prominent for improving drug design the CDK family. Multiple short dynamics (MD) simulations combined with MM-GBSA approach are adopted to investigate on binding selectivity X64, X3A, and 4 AU CDK6. The RMSF analysis calculations surface areas indicate that local structural global flexibility stronger than CDK2. Based cross-correlation maps (DCCMs), motion modes produce difference due associations...
Cyclin-dependent kinase 6 (CDK6) has been identified as a potential drug target in various types of cancers. In our current study, multiple independent molecular dynamics simulations four separate replicates and computations binding free energies are carried out to decipher the mechanisms three inhibitors, LQQ, 6ZV, 0RS, CDK6. The dynamic analyses indicate that presence inhibitors influences conformational alterations, motion modes, internal Binding computed using mechanics generalized Born...
Abstract The dynamic interplay between tumor‐associated macrophages (TAMs) and anaplastic thyroid cancer (ATC) shapes the tumor microenvironment facilitates ATC progression. However, mechanisms of communication TAMs stem cells (ATCSCs) remain largely unelucidated. Integrative analyses single‐cell RNA sequencing, cytokine/chemokine arrays, proteomics, mRNA expression datasets are performed to reveal crosstalk ATCSCs signaling pathways in ATCSCs. Subsequently, vitro experiments validate...
ABSTRACT Ultrasound‐guided intrauterine insemination (IUI) has been successfully employed in cynomolgus macaques, yet its effectiveness large‐scale, multi‐age cohorts not fully explored. Here, we implemented IUI within large breeding colonies to boost pregnancy rates macaques. Ovulation timing was estimated by monitoring menstrual bleeding, after which performed. We then compared single cycle (SMC) between groups and harem‐style mating groups. Our findings revealed that the overall rate...
The colloidal LDH nanosheets have been assembled in aqueous medium with three proteins having different structures and surface charge distributions. In addition to the interfacial adsorption features, secondary and/or higher level of surface-bound are investigated by ATR-FTIR fluorescence spectroscopic techniques. structure conformation porcine pancreatic lipase (PPL), for which negative charges concentrated on side opposite active sites, well retained, but orientations PPL molecules...
Calycosin is a bioactive component of Astragali Radix, Chinese herb for treating allergy. We have previously demonstrated that calycosin effectively inhibited allergic inflammation efficiently. The aim this study was to explore the mechanism on epithelial cells in inflammation.An initial stage atopic dermatitis (AD) model which mice were just sensitized with FITC, established vivo and immortalized human keratinocytes (HaCaT cells) utilized vitro. Initiative key cytokines, TSLP IL-33,...
Our previous studies suggested that paeonol, the active constituent of traditional Chinese medicine Cortex Moutan, may be an effective treatment for inflammatory disorders. In present study, therapeutic potential paeonol on atopic dermatitis (AD) was investigated using animal and cell experiments. AD‑like lesions were induced by repeated application 1‑chloro‑2,4‑dinitrobenzene (DNCB) to shaved dorsal skin BALB/c mice, P815 cells used in vitro assays. The lesions, serum spleens mice analyzed...
Scope:As DNA methylation is one of the key epigenetic mechanisms involved in embryonic muscle development, elucidating its relationship with non-coding RNAs and genes essential for understanding early development.The methylome profiles pre-hatching chicken across multiple developmental stages remain incomplete although several related studies have been reported.Methods: In this study, we performed single-base-resolution bisulfite sequencing together RNA-seq broilers layers different...
Well-regulated differentiation of fibroblasts into myofibroblasts (MF) is critical for skin wound healing. Neoexpression α-smooth muscle actin (α-SMA), an established marker MF differentiation, driven by TGFβ receptor (TGFβR)–mediated signaling. Hyaluronan (HA) and its CD44 may also participate in this process. To further understand process, primary mouse were isolated treated vitro with recombinant TGF-β1 (rTGF-β1) to induce α-SMA expression. expression was increased. Paradoxically,...