A5100616393- Dermatology and Skin Diseases
- Skin and Cellular Biology Research
- Allergic Rhinitis and Sensitization
- RNA regulation and disease
- Asthma and respiratory diseases
- Climate Change and Health Impacts
- Fungal Infections and Studies
- Metabolism and Genetic Disorders
- Antifungal resistance and susceptibility
- Cardiac Arrhythmias and Treatments
- Dermatological and Skeletal Disorders
- Autoimmune Bullous Skin Diseases
- Thermoregulation and physiological responses
- Cell Adhesion Molecules Research
- RNA Research and Splicing
- Food Allergy and Anaphylaxis Research
- Connective tissue disorders research
- Contact Dermatitis and Allergies
- Cancer and Skin Lesions
- Blood disorders and treatments
- Nail Diseases and Treatments
- Body Composition Measurement Techniques
- Hair Growth and Disorders
- Liver Disease Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
XinHua Hospital
2016-2025
Shanghai Jiao Tong University
2014-2025
Children's Hospital of Fudan University
2024
Henan Provincial People's Hospital
2024
First Hospital of China Medical University
2022
Affiliated Hospital of Guizhou Medical University
2022
Shanghai Municipal Center For Disease Control Prevention
2019-2020
Health professions preventing and controlling Coronavirus Disease 2019 are prone to skin mucous membrane injury, which may cause acute chronic dermatitis, secondary infection aggravation of underlying diseases. This is a consensus Chinese experts on protective measures advice hand-cleaning- medical-glove-related hand protection, mask- goggles-related face UV-related eye nasal oral mucosa outer ear, hair protection. It necessary strictly follow standards wearing equipment specification...
Dupilumab subcutaneous injection is approved for treating moderate-to-severe atopic dermatitis (AD) in adolescents, but there has been too little research on an efficacious systemic oral treatment with a favorable benefit-risk profile adolescents AD.To investigate the efficacy and safety of abrocitinib plus topical therapy AD.The phase 3, randomized, double-blind, placebo-controlled study JADE TEEN was conducted countries Asia-Pacific region, Europe, North America patients aged 12 to 17...
Abstract Prevalence of atopic dermatitis (AD) is increasing worldwide. Up to date, there has been no face-to-face nation-wide study in China. We aim explore the prevalence clinical diagnosed AD children aged 1–7 ys Twelve metropolises were chosen from different areas In each region, we selected 4–10 kindergartens and 2–5 vaccination clinics randomly. A complete history-taking skin examination performed by dermatologists. The definite diagnosis severity determined two or three All criteria...
Atopic dermatitis (AD) is an inflammatory skin disease characterized by chronic recurrent with profound itching. Most patients have personal and/or family history of atopic diseases. Several criteria been proposed for the diagnosis AD. Although clinical features childhood AD widely studied, there has less large-scale study on adult/adolescent The aim this was to investigate symmetrical eczema/AD and propose Chinese diagnostic AD.A hospital-based performed. Forty-two dermatological centers...
Abstract Immune cell trafficking, an essential mechanism for maintaining immunological homeostasis and mounting effective responses to infections, operates under a stringent regulatory framework. Recent advances have shed light on the perturbation of migration patterns, highlighting how such disturbances can propagate inflammatory diseases from their origin distal organs. This review collates discusses current evidence that demonstrates atypical communication between gut skin, which are...
Abstract Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but the underlying molecular mechanism remains unclear. We demonstrate here that acid-sensing ion channel 3 (ASIC3) exacerbates psoriatic inflammation through a sensory pathway. Global or nociceptor-specific Asic3 knockout (KO) in female mice alleviates imiquimod-induced acanthosis and type 17 to same extent as nociceptor ablation. However, ASIC3 dispensable for IL-23-induced bypasses need...
Cryptococcosis has been reported to be mostly associated with non-HIV-related patients in China. However, little is known about the molecular characteristics of clinical isolates from Cryptococcus neoformans species complex this country. In study, 115 were included. Molecular type VNI was most representative (n=103), followed by VGI (n=8), VNIII (n=2), VNIV (n=1), and VGII (n=1). With exception a serotype D mating isolate, all possessed MATalpha locus. Multilocus sequence typing (MLST)...
Recently, loss-of-function mutations in the filaggrin gene (FLG) have been identified as cause of ichthyosis vulgaris (IV) and also predisposing factors for atopic dermatitis (AD) AD-associated phenotypes. Until now, over thirty FLG patients with IV AD, but mutation spectrum is not clear Chinese Han AD. This study aimed to investigate role AD phenotypes a population.We carried out comprehensive sequencing entire coding region 261 patients.In our research, we ten novel (R826X, 3222del4,...
Abstract Neurofibromatosis type 1 ( NF1 ) is an autosomal dominant hereditary disease that primarily characterized by multiple café au-lait spots (CALs) and skin neurofibromas, which are attributed to defects in the tumor suppressor . Because of age-dependent presentation NF1, it often difficult make early clinical diagnosis. Moreover, identifying genetic alterations patients represents a complex challenge. Currently, there no effective detective methods comprehensive mutation data available...
Abstract Aberrant differentiation of keratinocytes has been demonstrated to be associated with a number skin diseases. A growing studies have showed that long noncoding RNAs (lncRNAs) an important part in gene regulation, however, the role lncRNAs keratinocyte remains largely unknown. In present study, we lncRNA-H19 act as endogenous 'sponge', which binds directly miR-130b-3p and therefore inhibits its activity on Dsg1. MiR-130b-3p was illustrated inhibit by targeting H19 regulates Dsg1...
Atopic dermatitis (AD) is the most common skin disorder in infancy. However, diagnosis and definite significance of infantile AD remains a debated issue.To analyse phenotypes infancy, to establish diagnostic criteria estimate prevalence this condition China.This multicentric study, which 12 locations were chosen from different metropolitan areas China. Following careful complete history-taking examination, was made severity based on SCORAD index determined by local experienced...
Abstract Olmsted syndrome (OS) is a rare keratinization disorder, typically characterized by two primary diagnostic hallmarks—mutilating palmoplanter and periorificial keratoderma. However, there’s growing body of literature reporting on the phenotypic diversity OS, including absence aforementioned hallmarks presence some unusual clinical features. Here we presented an atypical familial case OS that could be confused with Huriez due to scleodactyly-like appearance tapered fingers in proband....
Abstract Since late 2012, coxsackievirus A6 (CVA6) has gradually become the predominant pathogen responsible for hand-foot-mouth disease (HFMD) in several provinces of China. A total 626 patients diagnosed with HFMD Shanghai, China from January 2012 to September 2013 were enrolled this study. Of these, 292 CVA6 infected cases subjected clinical analyses. Whole-genome sequencing, recombination and phylogenetic analyses also performed. recombinant monophyletic lineage was found during an...
Geographic tongue (GT) is a benign inflammatory disorder of unknown etiology. Epidemiology and histopathology in previous studies found that generalized pustular psoriasis (GPP) factor associated with GT, but the molecular mechanism remains obscure. To investigate without GPP, three cohorts were recruited to conduct genotyping IL36RN, which causative gene GPP. In family spanning generations diagnosed only GT ("GT alone"), was caused by c.115+6T>C/p.Arg10ArgfsX1 mutation IL36RN gene. An...
Junctional epidermolysis bullosa (JEB) is characterized by mucocutaneous fragility. We enrolled 69 cases of recessive JEB, with 13.0% these remained genetically undiagnosed following an initial exome sequencing. Among carried COL17A1 variants, this proportion can reach 31.6%. employed genome sequencing to diagnosis cases. Four deep intronic variants (c.4156+117 G > A, c.2039-104 A and c.1267+237dupC in the gene c.-38 + 2 T C LAMB3 gene) were identified six The c.4156+117 variant was found...
ABSTRACT Subjects carrying variants in the caspase recruitment domain family member 14 ( CARD14 ) gene can exhibit characteristics of psoriasis and pityriasis rubra pilaris (PRP). The term ‘CARD14‐associated papulosquamous eruption (CAPE)’ is used to describe individuals presenting with symptoms both conditions. This study aimed diagnose two cases CAPE explore pathogenic mechanisms, including inflammatory trends differential features. Whole‐exome sequencing Sanger identified a novel variant,...
Based on social exchange theory, the present study constructed a moderated mediation model to examine effect of affective leadership employees’ knowledge sharing behaviors. Through statistical analysis 351 sample data collected at two time points, finds that has significant positive behavior. Organizational trust mediates influence Supervisor's organizational embodiment moderates relationship between and in is more stronger when supervisor's high. Moreover, find indirect behavior via trust.