A5101920589- Inflammasome and immune disorders
- Dermatology and Skin Diseases
- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- Allergic Rhinitis and Sensitization
- Acupuncture Treatment Research Studies
- Psoriasis: Treatment and Pathogenesis
- Gout, Hyperuricemia, Uric Acid
- Traditional Chinese Medicine Analysis
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Mitochondrial Function and Pathology
- Migraine and Headache Studies
- Bioactive Compounds and Antitumor Agents
- Genomics, phytochemicals, and oxidative stress
- Traumatic Brain Injury and Neurovascular Disturbances
- Glaucoma and retinal disorders
- Music Therapy and Health
- Autophagy in Disease and Therapy
- Sunflower and Safflower Cultivation
- Vagus Nerve Stimulation Research
- Zebrafish Biomedical Research Applications
- vaccines and immunoinformatics approaches
Beijing Hospital of Traditional Chinese Medicine
2016-2024
Capital Medical University
2016-2024
Beijing YouAn Hospital
2024
Harvard University
2020
Boston Children's Hospital
2020
Brigham and Women's Hospital
2020
Jilin University
2018-2019
Tianjin Medical University
2019
Northwest A&F University
2018
Jilin Medical University
2018
Intestinal epithelial barrier dysfunction is crucial in the pathogenesis of intestinal and systemic diseases. Ferulic acid (FA) possesses promising antioxidant activities. In a previous study, we demonstrated potentially protective effects FA against heat stress-induced IEC-6 cells. However, underlying mechanisms are unclear. The present study aimed to elucidate whether protects cells from via antioxidative mechanisms.IEC-6 were pretreated with prior hyperthermia exposure at 42 °C for 6 h,...
Intestinal barrier dysfunction is an important clinical problem in various acute and chronic pathological conditions. Ferulic acid (FA) can attenuate the intestinal epithelial dysfunction, however, underlying mechanism remains unclear. The present study aimed to uncover protective effect of FA on a Caco-2 cell model lipopolysaccharide (LPS) stimulation mechanism. cells were pretreated with then exposed LPS stimulation. function was evaluated by measuring trans-epithelial resistance (TER)...
Acupuncture has a therapeutic effect similar to that of prophylactic drugs and can be considered treatment option for migraineurs. However, the mechanism acupuncture treatment's on migraine is uncertain. An approach based anti-inflammatory effects an important strategy because non-steroidal (NSAIDs) are usually used during attacks. Meningeal inflammation thought responsible activation trigeminovascular system. Our previous study found electroacupuncture (EA) decreased neurogenic mediator...
Our previous studies suggested that paeonol, the active constituent of traditional Chinese medicine Cortex Moutan, may be an effective treatment for inflammatory disorders. In present study, therapeutic potential paeonol on atopic dermatitis (AD) was investigated using animal and cell experiments. AD‑like lesions were induced by repeated application 1‑chloro‑2,4‑dinitrobenzene (DNCB) to shaved dorsal skin BALB/c mice, P815 cells used in vitro assays. The lesions, serum spleens mice analyzed...
Hydroxysafflor yellow A (HSYA) is an effective therapeutic agent for inflammatory diseases and autoimmune disorders; however, its regulatory effect on NLRP3 inflammasome activation in macrophages has not been investigated. In this study, we predicted the potential interaction between HSYA xanthine oxidase (XO) via PharmMapper inverse docking confirmed binding inhibition inhibitory test (IC 50 = 40.04 μ M). Computation illustrated that, HSYA-XO complex, was surrounded by Leu 648, 712, His...
Sepsis-induced inflammatory response leads to intestinal damage and secondary bacterial translocation, causing systemic infections eventually death. Emodin is a natural anthraquinone derivative in many plants with promising bioactivities. However, the effects mechanisms of emodin on sepsis-induced dysfunctions have not been well clarified yet. We found that treatment suppressed intestines septic mice. Intestinal barrier function was also improved by through enhancing ZO-1 occludin...
Sepsis has a high mortality rate, and treating sepsis remains significant challenge worldwide. In former studies, our group found that traditional Chinese medicine, Shen FuHuang formula (SFH), is promising medicine in coronavirus disease 2019 (COVID-19) patients with the septic syndrome. However, underlying mechanisms remain elusive. present study, we first investigated therapeutic effects of SFH on mice. To investigate SFH-treated sepsis, identified gut microbiome profile exploited...
Psoriasis is an inflammation-based skin illness marked by aggravated proliferation of epidermal cells. Shikonin a natural naphthoquinone obtained from Arnebiae radix. It exerts anti-inflammatory and immunosuppressive effects. However, the poor water solubility low bioavailability shikonin limit its application. In this study, shikosin-loaded PLGA nanoparticle hydrogel was prepared used to deliver drug epidermis psoriasis mice through local administration. The results demonstrated that...
The clinical efficacy of immunotherapy for hepatocellular carcinoma (HCC) is significantly limited by the low immunogenicity tumor. Recent studies have revealed that both pyroptosis and photothermal therapy can effectively induce tumor immunogenic cell death (ICD) in liver cancer cells. Polyphyllin II (PPII), major active component Rhizoma Paridis, has been demonstrated first time to cells, while IR780 activated 808 nm laser transform light energy into heat energy, eliminating However, PPII...
Sepsis is reported to be an unusual systemic reaction infection, accompanied by multiple-organ failure. Sepsis-induced cardiomyopathy, defined as damages and dysfunction of the heart, essential in pathogenesis sepsis. Traditional Chinese formula, which has long been used improve situation patients through multitarget regulation, now gradually being complementary therapy. The present study aimed investigate effect Qiang-Xin 1 (QX1) a traditional herbal medicine designed for cardiac...
Cardiac dysfunction is a critical manifestation of sepsis-induced multiorgan failure and results in the high mortality sepsis. Our previous study demonstrated that traditional Chinese medicine formula, Qiang-Xin 1 (QX1), ameliorates cardiac tissue damage septic mice; however, underlying pharmacology mechanism remains to be elucidated. The present was aimed at clarifying protective QX1 formula on dysfunction. moderate sepsis model mice established by cecal ligation puncture surgery. Treatment...
Introduction Approximately 1.4%–2.2% of the global population suffers from chronic migraine. Acupuncture may serve as an alternative management for migraine, where pharmacological prophylaxis is not suitable. However, effects acupuncture migraine have been confirmed. This study designed a single-blinded, double-dummy randomised controlled trial to evaluate efficacy and safety compared with topiramate in patients Methods analysis A total 60 participants will be randomly assigned two different...
Psoriasis is a common autoimmune disease. Acupuncture-related techniques have been widely used to treat psoriasis since its ability engage neuronal function, the immune system, and other systems well documented. This study aimed investigate compare effects of three acupuncture-related in psoriasis-like skin inflammatory responses explore possible involved mechanisms. Imiquimod (IMQ)-induced mice were treated with acupuncture needling, electroacupuncture, or fire acupuncture. Methotrexate...
The outbreak of coronavirus disease 2019 (COVID-19) has affected millions people worldwide. Critically ill COVID-19 patients develop viral septic syndrome, including inflammatory damage, immune dysfunction, and coagulation disorder. In this study, we investigated ShenFuHuang formula (SFH), a traditional Chinese medicine, which been widely used as complementary therapy for clinical treatment in Wuhan, to understand its pharmacological properties. Results systems pharmacology identified 49...
Cao Huang Gui Xiang (CHGX) formula, a Chinese herbal medicine, has been empirically used for the treatment of Candida infections. In present study, we discovered that CHGX showed potent antifungal activities against major human fungal pathogen albicans and other clinical species. Besides, indicated had in vivo efficacy on treating C. infection mice without noticeable toxicity at therapeutic concentration. We then set out to investigate mechanisms albicans. found played an important role...
Alteration in airway microbiota composition and perturbations microbe-metabolites interactions have been proposed as markers of many diseases. Liu Shen (LS) capsule, a traditional Chinese medicine, was proved favorable treating respiratory However, the effects LS capsule terms regulating human microorganisms metabolite profiles are not well known. This study aimed to define compare circulating fecal before after administration. A total 30 healthy volunteers were recruited. The pharyngeal...