A5020141885- Autophagy in Disease and Therapy
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Ginseng Biological Effects and Applications
- Acupuncture Treatment Research Studies
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
- Pediatric health and respiratory diseases
- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Long-Term Effects of COVID-19
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Studies
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Sepsis Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Heat shock proteins research
- Cancer, Hypoxia, and Metabolism
- Cellular transport and secretion
- Genomics, phytochemicals, and oxidative stress
- Calcium signaling and nucleotide metabolism
- Psoriasis: Treatment and Pathogenesis
- Fungal Infections and Studies
- Pneumonia and Respiratory Infections
Beijing Hospital of Traditional Chinese Medicine
2016-2025
Capital Medical University
2016-2025
Beijing University of Chinese Medicine
2023-2025
Institute of Environment and Sustainable Development in Agriculture
2025
Chinese Academy of Agricultural Sciences
2025
Southern University of Science and Technology
2024-2025
Jinan University
2024-2025
Jiangsu Agri-animal Husbandry Vocational College
2025
Zhejiang Medicine (China)
2024
China Agricultural University
2013-2024
MicroRNAs have an important role in bone homeostasis. However, the detailed mechanism of microRNA-mediated intercellular communication between cells remains elusive. Here, we report that osteoclasts secrete microRNA-enriched exosomes, by which miR-214 is transferred into osteoblasts to inhibit their function. In a coculture system, inhibition exosome formation and secretion prevented transportation. Exosomes specifically recognized through interaction ephrinA2 EphA2. osteoclast-specific...
microRNA is necessary for osteoclast differentiation, function and survival. It has been reported that miR-199/214 cluster plays important roles in vertebrate skeletal development miR-214 inhibits osteoblast by targeting ATF4. Here, we show up-regulated during osteoclastogenesis from bone marrow monocytes (BMMs) with macrophage colony stimulating factor (M-CSF) receptor activator of nuclear factor-κB ligand (RANKL) induction, which indicates a critical role differentiation. Overexpression...
Reactive oxygen species (ROS) and oxidative stress are thought to play a central role in potentiating macrophage activation, causing excessive inflammation, tissue damage, sepsis. Recently, we have shown that punicalagin (PUN) exhibits anti-inflammatory activity LPS-stimulated macrophages. However, the potential antioxidant effects of PUN macrophages remain unclear. Revealing these will help understand mechanism underlying its ability inhibit activation. Hemeoxygenase-1 (HO-1) Therefore,...
Intestinal epithelial barrier dysfunction is crucial in the pathogenesis of intestinal and systemic diseases. Ferulic acid (FA) possesses promising antioxidant activities. In a previous study, we demonstrated potentially protective effects FA against heat stress-induced IEC-6 cells. However, underlying mechanisms are unclear. The present study aimed to elucidate whether protects cells from via antioxidative mechanisms.IEC-6 were pretreated with prior hyperthermia exposure at 42 °C for 6 h,...
Abstract The ULK complex initiates the autophagosome formation, and has recently been implicated in selective autophagy by interacting with receptors through its FIP200 subunit. However, structural mechanism underlying interactions of relevant regulatory remain elusive. Here, we discover that Claw domain CCPG1 Optineurin can be regulated phosphorylation their respective FIP200-binding regions. We determine crystal structures phosphorylated Optineurin, elucidate detailed molecular governing...
Bacterial outer membrane vesicles (OMVs) are promising as antitumour agents, but their clinical application is limited by toxicity concerns and unclear mechanisms. We engineered OMVs with cadherin 17 (CDH17) tumour-targeting nanobodies, enhancing tumour selectivity efficacy while reducing adverse effects. These function natural stimulator of interferon genes (STING) agonists, activating the cyclic GMP-AMP synthase (cGAS)-STING pathway in cancer cells tumour-associated macrophages (TAMs)....
Fisetin, a natural flavonoid found in variety of edible and medical plants, has been suggested to inhibit the proliferation various tumor cells induce apoptosis. However, effects fisetin on breast cancer have rarely reported underlying mechanism is still undefined. The present study explored anti‑cancer mammary carcinoma mechanisms. Following treatment with fisetin, viability 4T1, MCF‑7 MDA‑MB‑231 were measured by MTT assay. inhibitory proliferation, migration invasion evaluated 4T1 using...
The effect of competing endogenous RNA (ceRNA) can regulate gene expression by competitively binding microRNAs. Fascin-1 (FSCN1) plays an important role in the regulation cellular migration and invasion during tumor progression, but how its regulatory mechanism works through ceRNA is still unclear bladder cancer (BLCA).The fascin-1, miR-200b, ZEB1-AS1 BLCA was investigated vitro vivo. interaction between identified using bioinformatics analysis, luciferase activity assays, RNA-binding...
Intestinal barrier dysfunction is an important clinical problem in various acute and chronic pathological conditions. Ferulic acid (FA) can attenuate the intestinal epithelial dysfunction, however, underlying mechanism remains unclear. The present study aimed to uncover protective effect of FA on a Caco-2 cell model lipopolysaccharide (LPS) stimulation mechanism. cells were pretreated with then exposed LPS stimulation. function was evaluated by measuring trans-epithelial resistance (TER)...
Background: Reduning injection is a traditional Chinese medicine (TCM) with known efficacy against variety of viral infections, but there no data about its coronavirus disease 2019 (COVID-19).Methods: To explore the and safety in treatment COVID-19, randomized, open-labeled, multicenter, controlled trial was conducted from 12 general hospitals between 2020.02.06 2020.03.23. Patients COVID-19 who met diagnostic criteria "Diagnosis Treatment Program for Novel Coronavirus Infection Pneumonia...
Paeonol, an active component derived from the traditional Chinese medicine Cortex Moutan, possesses anti-inflammatory, analgesic, antioxidant and anti-allergic properties. Psoriasis is a chronic, recurrent, inflammatory dermatosis accompanied by excessive activation of Toll‑like receptors (TLRs) in dendritic cells (DCs), which are primarily responsible for initiating immune response. We investigated effect paeonol on inflammation imiquimod (IMQ)-induced psoriasis-like mouse model murine bone...
In bovine mammary epithelial cells (BMECs), a cascade of inflammatory reactions induced by lipopolysaccharide (LPS) has been shown to result in cell injury and apoptosis. The present study aims reveal the protective effect ferulic acid (FA) on LPS-induced BMEC apoptosis explore its potential molecular mechanisms. First, we showed that FA had low cytotoxicity BMECs significantly decreased proinflammatory response LPS. Next, blocked oxidative stress restoring balance redox state inhibiting...
The recruitment of Unc-51-like kinase and TANK-binding 1 complexes is essential for Nuclear dot protein 52-mediated selective autophagy relies on the specific association NDP52, RB1-inducible coiled-coil 1, Nak-associated (5-azacytidine-induced 2, AZI2). However, underlying molecular mechanism remains elusive. Here, we find that except NDP52 SKIP carboxyl homology (SKICH)/RB1CC1 interaction, LC3-interacting region can directly interact with RB1CC1 Claw domain, as NAP1 FIP200-binding (FIR)....
Abstract Allylation and benzylation of p ‐quinones was achieved through an unusual redox chain reaction. Mechanistic studies suggest that the existence trace hydroquinone initiates a reaction consists Lewis acid catalyzed Friedel–Crafts alkylation subsequent equilibrium regenerates hydroquinone. The electrophiles could be various allylic benzylic esters. addition Hantzsch ester as initiator improves efficiency
Abstract Background Renal colic is one of the worst types pain in acute renal caused by urinary calculi (ARCUC). We previously proved that acupuncture can alleviate ARCUC patients, but its effect on suspected remains unclear. Objective The objective was to evaluate effectiveness and safety patients with ARCUC. Design This prospective, double-blind, sham acupuncture-controlled, randomized clinical trial conducted from July 2021 June 2024 an emergency department China. Methods immediately...
This study assessed the immunogenicity and safety of a quadrivalent influenza split-virion vaccine (IIV4) in children with without prior vaccination. An open-label, phase IV clinical trial was conducted healthy aged 3–8 years Pizhou, Jiangsu Province, China. Children ≥2 doses vaccination (Influenza Vaccination Group) those no Vaccine-naïve were given two IIV4, 4 weeks apart. The primary endpoints seroprotection rates (SPRs) hemagglutination inhibition antibody 28 days after each dose against...